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Study · In vitro (cells) · 2020

6 results

Activation of AMP-activated protein kinase attenuates ethanol-induced ER/oxidative stress and lipid phenotype in human pancreatic acinar cells.

Srinivasan MP, Bhopale KK, Caracheo AA, Amer SM, Khan S, Kaphalia L, Loganathan G, Balamurugan AN, Kaphalia BS

Biochemical pharmacology25 Jul 2020Cited by 16 (Europe PMC)

PMID32717227 (opens in a new tab)PMCIDPMC7651864 (opens in a new tab)DOI10.1016/j.bcp.2020.114174 (opens in a new tab)PepBankPUB-32717227
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In ethanol-exposed pancreatic acinar cells, AICAR attenuated ER stress.

    In plain wordsIn cells exposed to ethanol, AICAR reduced endoplasmic reticulum stress compared with ethanol alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseER stress
    Study

    n: not reported in source

    ethanol-exposed hPACs and AR42J cells
    Comparator
    ethanol exposure without AICAR
    Outcome group
    Gene expression · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, AMPKα activation by AICAR attenuated EtOH-induced ER/oxidative stress, lipogenesis, and inflammatory responses as well as the formation of FAEEs and restored mitochondrial function in hPACs as well as AR42J cells.
    1 context sentence
    Summary · context
    in human pancreatic acinar cells (hPACs) and AR42J cells incubated with/without AMPKα activator [5-aminoimidazole-4-carboxamide ribonucleotide (AICAR)].
  2. 02LabIn vitro (cells)Mechanism

    In ethanol-exposed pancreatic acinar cells, AICAR attenuated oxidative stress.

    In plain wordsIn cells exposed to ethanol, AICAR reduced oxidative stress compared with ethanol alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseOxidative stress
    Study

    n: not reported in source

    ethanol-exposed hPACs and AR42J cells
    Comparator
    ethanol exposure without AICAR
    Outcome group
    Gene expression · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, AMPKα activation by AICAR attenuated EtOH-induced ER/oxidative stress, lipogenesis, and inflammatory responses as well as the formation of FAEEs and restored mitochondrial function in hPACs as well as AR42J cells.
    1 context sentence
    Summary · context
    in human pancreatic acinar cells (hPACs) and AR42J cells incubated with/without AMPKα activator [5-aminoimidazole-4-carboxamide ribonucleotide (AICAR)].
  3. 03LabIn vitro (cells)Mechanism

    In ethanol-exposed pancreatic acinar cells, AICAR attenuated lipogenesis.

    In plain wordsIn cells exposed to ethanol, AICAR reduced fat synthesis compared with ethanol alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseLipogenesis
    Study

    n: not reported in source

    ethanol-exposed hPACs and AR42J cells
    Comparator
    ethanol exposure without AICAR
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, AMPKα activation by AICAR attenuated EtOH-induced ER/oxidative stress, lipogenesis, and inflammatory responses as well as the formation of FAEEs and restored mitochondrial function in hPACs as well as AR42J cells.
    1 context sentence
    Summary · context
    in human pancreatic acinar cells (hPACs) and AR42J cells incubated with/without AMPKα activator [5-aminoimidazole-4-carboxamide ribonucleotide (AICAR)].
  4. 04LabIn vitro (cells)Mechanism

    In ethanol-exposed pancreatic acinar cells, AICAR attenuated inflammatory responses.

    In plain wordsIn cells exposed to ethanol, AICAR reduced inflammatory responses compared with ethanol alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseInflammatory responses
    Study

    n: not reported in source

    ethanol-exposed hPACs and AR42J cells
    Comparator
    ethanol exposure without AICAR
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, AMPKα activation by AICAR attenuated EtOH-induced ER/oxidative stress, lipogenesis, and inflammatory responses as well as the formation of FAEEs and restored mitochondrial function in hPACs as well as AR42J cells.
    1 context sentence
    Summary · context
    in human pancreatic acinar cells (hPACs) and AR42J cells incubated with/without AMPKα activator [5-aminoimidazole-4-carboxamide ribonucleotide (AICAR)].
  5. 05LabIn vitro (cells)Mechanism

    In ethanol-exposed pancreatic acinar cells, AICAR attenuated fatty acid ethyl ester formation.

    In plain wordsIn cells exposed to ethanol, AICAR reduced fatty acid ethyl ester formation compared with ethanol alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseFatty acid ethyl ester formation
    Study

    n: not reported in source

    ethanol-exposed hPACs and AR42J cells
    Comparator
    ethanol exposure without AICAR
    Outcome group
    Lipids · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, AMPKα activation by AICAR attenuated EtOH-induced ER/oxidative stress, lipogenesis, and inflammatory responses as well as the formation of FAEEs and restored mitochondrial function in hPACs as well as AR42J cells.
    1 context sentence
    Summary · context
    in human pancreatic acinar cells (hPACs) and AR42J cells incubated with/without AMPKα activator [5-aminoimidazole-4-carboxamide ribonucleotide (AICAR)].
  6. 06LabIn vitro (cells)Mechanism

    In ethanol-exposed pancreatic acinar cells, AICAR restored mitochondrial function.

    In plain wordsIn cells exposed to ethanol, AICAR restored mitochondrial function compared with ethanol alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseMitochondrial function
    Study

    n: not reported in source

    ethanol-exposed hPACs and AR42J cells
    Comparator
    ethanol exposure without AICAR
    Outcome group
    Mitochondrial function · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, AMPKα activation by AICAR attenuated EtOH-induced ER/oxidative stress, lipogenesis, and inflammatory responses as well as the formation of FAEEs and restored mitochondrial function in hPACs as well as AR42J cells.
    1 context sentence
    Summary · context
    in human pancreatic acinar cells (hPACs) and AR42J cells incubated with/without AMPKα activator [5-aminoimidazole-4-carboxamide ribonucleotide (AICAR)].

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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