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Study · In vitro (cells) · 2013

6 results

Exercise-inducible factors to activate lipolysis in adipocytes.

Hashimoto T, Sato K, Iemitsu M

Journal of applied physiology (Bethesda, Md. : 1985)16 May 2013Cited by 24 (Europe PMC)

PMID23681914 (opens in a new tab)DOI10.1152/japplphysiol.00427.2013 (opens in a new tab)PepBankPUB-23681914
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In 3T3-L1 adipocytes, AICAR significantly increased glycerol release, as did all tested treatments.

    In plain wordsIn cells, AICAR increased glycerol release, as did all tested treatments.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseGlycerol release
    Study

    n: not reported in source

    Differentiated 3T3-L1 adipocytes
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated · 6 hAs given in this study.

    Source sentences

    Summary
    In 3T3-L1 cells, glycerol or fatty acid release was significantly increased by all treatments.
    1 context sentence
    Summary · context
    3T3-L1 adipocytes were incubated with media containing hydrogen peroxide (H2O2), sodium-lactate, caffeine, AICAR, or SNAP (NO donor) for 6 h, or 1 mM H2O2 for 15 min, followed by incubation with normal media for up to 24 h total.
  2. 02LabIn vitro (cells)Mechanism

    In 3T3-L1 adipocytes, AICAR significantly increased fatty acid release, as did all tested treatments.

    In plain wordsIn cells, AICAR increased fatty acid release, as did all tested treatments.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseFatty acid release
    Study

    n: not reported in source

    Differentiated 3T3-L1 adipocytes
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated · 6 hAs given in this study.

    Source sentences

    Summary
    In 3T3-L1 cells, glycerol or fatty acid release was significantly increased by all treatments.
    1 context sentence
    Summary · context
    3T3-L1 adipocytes were incubated with media containing hydrogen peroxide (H2O2), sodium-lactate, caffeine, AICAR, or SNAP (NO donor) for 6 h, or 1 mM H2O2 for 15 min, followed by incubation with normal media for up to 24 h total.
  3. 03LabIn vitro (cells)Mechanism

    In 3T3-L1 adipocytes, AICAR significantly increased perilipin expression, as did all tested treatments.

    In plain wordsIn cells, AICAR increased perilipin expression, as did all tested treatments.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePerilipin expression
    Study

    n: not reported in source

    Differentiated 3T3-L1 adipocytes
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated · 6 hAs given in this study.

    Source sentences

    Summary
    Expression of perilipin, HSL, ATGL, or comparative gene identification (CGI)-58 was significantly increased by all treatments.
    1 context sentence
    Summary · context
    3T3-L1 adipocytes were incubated with media containing hydrogen peroxide (H2O2), sodium-lactate, caffeine, AICAR, or SNAP (NO donor) for 6 h, or 1 mM H2O2 for 15 min, followed by incubation with normal media for up to 24 h total.
  4. 04LabIn vitro (cells)Mechanism

    In 3T3-L1 adipocytes, AICAR significantly increased HSL expression, as did all tested treatments.

    In plain wordsIn cells, AICAR increased HSL expression, as did all tested treatments.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseHSL expression
    Study

    n: not reported in source

    Differentiated 3T3-L1 adipocytes
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated · 6 hAs given in this study.

    Source sentences

    Summary
    Expression of perilipin, HSL, ATGL, or comparative gene identification (CGI)-58 was significantly increased by all treatments.
    1 context sentence
    Summary · context
    3T3-L1 adipocytes were incubated with media containing hydrogen peroxide (H2O2), sodium-lactate, caffeine, AICAR, or SNAP (NO donor) for 6 h, or 1 mM H2O2 for 15 min, followed by incubation with normal media for up to 24 h total.
  5. 05LabIn vitro (cells)Mechanism

    In 3T3-L1 adipocytes, AICAR significantly increased ATGL expression, as did all tested treatments.

    In plain wordsIn cells, AICAR increased ATGL expression, as did all tested treatments.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseATGL expression
    Study

    n: not reported in source

    Differentiated 3T3-L1 adipocytes
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated · 6 hAs given in this study.

    Source sentences

    Summary
    Expression of perilipin, HSL, ATGL, or comparative gene identification (CGI)-58 was significantly increased by all treatments.
    1 context sentence
    Summary · context
    3T3-L1 adipocytes were incubated with media containing hydrogen peroxide (H2O2), sodium-lactate, caffeine, AICAR, or SNAP (NO donor) for 6 h, or 1 mM H2O2 for 15 min, followed by incubation with normal media for up to 24 h total.
  6. 06LabIn vitro (cells)Mechanism

    In 3T3-L1 adipocytes, AICAR significantly increased CGI-58 expression, as did all tested treatments.

    In plain wordsIn cells, AICAR increased CGI-58 expression, as did all tested treatments.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseCGI-58 expression
    Study

    n: not reported in source

    Differentiated 3T3-L1 adipocytes
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated · 6 hAs given in this study.

    Source sentences

    Summary
    Expression of perilipin, HSL, ATGL, or comparative gene identification (CGI)-58 was significantly increased by all treatments.
    1 context sentence
    Summary · context
    3T3-L1 adipocytes were incubated with media containing hydrogen peroxide (H2O2), sodium-lactate, caffeine, AICAR, or SNAP (NO donor) for 6 h, or 1 mM H2O2 for 15 min, followed by incubation with normal media for up to 24 h total.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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