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Study · In vitro (cells) · 2023

2 results

FGF21 promotes myocardial angiogenesis and mediates the cardioprotective effects of exercise in myocardial infarction mice.

Bo W, Ma Y, Feng L, Yu M, Zhang L, Cai M, Song W, Xi Y, Tian Z

Journal of applied physiology (Bethesda, Md. : 1985)3 Aug 2023Cited by 11 (Europe PMC)

PMID37535710 (opens in a new tab)DOI10.1152/japplphysiol.00307.2023 (opens in a new tab)PepBankPUB-37535710
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In HUVEC experiments, AICAR enhanced angiogenesis through FGF21/FGFR1/PI3K/AKT/VEGF signaling.

    In plain wordsIn cells, AICAR enhanced blood vessel formation through the FGF21 signaling pathway.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAngiogenesis
    Study

    humann: not reported in source

    human umbilical vein endothelial cells
    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) enhanced angiogenesis and cell migration through FGF21/FGFR1/PI3K/AKT/VEGF signaling pathway.
    2 context sentences
    Summary · context
    In vitro, human umbilical vein endothelial cells (HUVECs) were treated with H2O2, recombinant human FGF21 (rhFGF21), fibroblast growth factor receptor 1 (FGFR1) inhibitor (PD166866), and phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002) to explore the potential mechanisms.
    Summary · context
    Scratch wound healing and tubule formation analysis were used to detect the migration and tubule formation ability of HUVECs.
  2. 02LabIn vitro (cells)Efficacy outcome

    In HUVEC experiments, AICAR enhanced cell migration through FGF21/FGFR1/PI3K/AKT/VEGF signaling.

    In plain wordsIn cells, AICAR enhanced cell movement through the FGF21 signaling pathway.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseCell migration
    Study

    humann: not reported in source

    human umbilical vein endothelial cells
    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) enhanced angiogenesis and cell migration through FGF21/FGFR1/PI3K/AKT/VEGF signaling pathway.
    2 context sentences
    Summary · context
    In vitro, human umbilical vein endothelial cells (HUVECs) were treated with H2O2, recombinant human FGF21 (rhFGF21), fibroblast growth factor receptor 1 (FGFR1) inhibitor (PD166866), and phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002) to explore the potential mechanisms.
    Summary · context
    Scratch wound healing and tubule formation analysis were used to detect the migration and tubule formation ability of HUVECs.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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