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Study · In vitro (cells) · 2018

8 results

Metformin ameliorates activation of hepatic stellate cells and hepatic fibrosis by succinate and GPR91 inhibition.

Nguyen G, Park SY, Le CT, Park WS, Choi DH, Cho EH

Biochemical and biophysical research communications24 Dec 2017Cited by 48 (Europe PMC)

PMID29278707 (opens in a new tab)DOI10.1016/j.bbrc.2017.12.143 (opens in a new tab)PepBankPUB-29278707
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In palmitate- or succinate-activated LX-2 cells, AICAR suppressed α-SMA expression.

    In plain wordsIn cells activated by palmitate or succinate, AICAR reduced α-SMA expression.

    Peptide
    AICAR (acadesine)
    Outcome
    Decreaseα-SMA expression
    Study

    humann: not reported in source

    Activated LX-2 hepatic stellate cells
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In our study, metformin and 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside (AICAR), which is an analog of adenosine monophosphate, were shown to suppress α-SMA expression via enhanced phosphorylation of AMP-activated protein kinase (AMPK) and inhibition of succinate-GPR91 signaling in activated…
    1 context sentence
    Summary · context
    The immortalized human HSCs, LX-2 cells, were used for the in vitro study.
  2. 02LabIn vitro (cells)Mechanism

    In palmitate- or succinate-activated LX-2 cells, AICAR enhanced AMPK phosphorylation.

    In plain wordsIn cells activated by palmitate or succinate, AICAR increased AMPK phosphorylation.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAMPK phosphorylation
    Study

    humann: not reported in source

    Activated LX-2 hepatic stellate cells
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In our study, metformin and 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside (AICAR), which is an analog of adenosine monophosphate, were shown to suppress α-SMA expression via enhanced phosphorylation of AMP-activated protein kinase (AMPK) and inhibition of succinate-GPR91 signaling in activated…
    1 context sentence
    Summary · context
    The immortalized human HSCs, LX-2 cells, were used for the in vitro study.
  3. 03LabIn vitro (cells)Mechanism

    In palmitate- or succinate-activated LX-2 cells, AICAR inhibited succinate-GPR91 signaling.

    In plain wordsIn cells activated by palmitate or succinate, AICAR reduced succinate-GPR91 signaling.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseSuccinate-GPR91 signaling
    Study

    humann: not reported in source

    Activated LX-2 hepatic stellate cells
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In our study, metformin and 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside (AICAR), which is an analog of adenosine monophosphate, were shown to suppress α-SMA expression via enhanced phosphorylation of AMP-activated protein kinase (AMPK) and inhibition of succinate-GPR91 signaling in activated…
    1 context sentence
    Summary · context
    The immortalized human HSCs, LX-2 cells, were used for the in vitro study.
  4. 04LabIn vitro (cells)Mechanism

    In palmitate-treated LX-2 cells, AICAR reduced succinate concentrations in cell lysates.

    In plain wordsIn cells treated with palmitate, AICAR reduced succinate concentrations.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseSuccinate concentration
    Study

    humann: not reported in source

    Activated LX-2 hepatic stellate cells
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Metformin and AICAR also reduced succinate concentration in the cell lysates when LX-2 cells were treated with palmitate.
    1 context sentence
    Summary · context
    The immortalized human HSCs, LX-2 cells, were used for the in vitro study.
  5. 05LabIn vitro (cells)Mechanism

    In succinate-treated LX-2 cells, AICAR reduced interleukin-6 production.

    In plain wordsIn cells treated with succinate, AICAR reduced interleukin-6 production.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseInterleukin-6 production
    Study

    humann: not reported in source

    Activated LX-2 hepatic stellate cells
    Outcome group
    Inflammation markers · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, metformin and AICAR reduced interleukin-6 and, transforming growth factor-β1 production in succinate-treated LX-2 cells.
    1 context sentence
    Summary · context
    The immortalized human HSCs, LX-2 cells, were used for the in vitro study.
  6. 06LabIn vitro (cells)Mechanism

    In succinate-treated LX-2 cells, AICAR reduced transforming growth factor-β1 production.

    In plain wordsIn cells treated with succinate, AICAR reduced transforming growth factor-β1 production.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseTransforming growth factor-β1 production
    Study

    humann: not reported in source

    Activated LX-2 hepatic stellate cells
    Outcome group
    Inflammation markers · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, metformin and AICAR reduced interleukin-6 and, transforming growth factor-β1 production in succinate-treated LX-2 cells.
    1 context sentence
    Summary · context
    The immortalized human HSCs, LX-2 cells, were used for the in vitro study.
  7. 07LabIn vitro (cells)Mechanism

    In LX-2 cells, AICAR inhibited succinate-stimulated hepatic stellate cell proliferation.

    In plain wordsIn cells, AICAR reduced succinate-stimulated liver cell proliferation.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseHSC proliferation
    Study

    humann: not reported in source

    Activated LX-2 hepatic stellate cells
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both metformin and AICAR inhibited succinate-stimulated HSC proliferation and cell migration.
    1 context sentence
    Summary · context
    The immortalized human HSCs, LX-2 cells, were used for the in vitro study.
  8. 08LabIn vitro (cells)Mechanism

    In LX-2 cells, AICAR inhibited succinate-stimulated hepatic stellate cell migration.

    In plain wordsIn cells, AICAR reduced succinate-stimulated liver cell migration.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseHSC migration
    Study

    humann: not reported in source

    Activated LX-2 hepatic stellate cells
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both metformin and AICAR inhibited succinate-stimulated HSC proliferation and cell migration.
    1 context sentence
    Summary · context
    The immortalized human HSCs, LX-2 cells, were used for the in vitro study.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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