In renal tubular cells, AICAR mimicked adiponectin's attenuation of ANG II-induced NADPH oxidase activation.
In plain wordsIn cells, AICAR reduced ANG II-induced NADPH oxidase activation, as adiponectin did.
- Peptide
- AICAR (acadesine)
- Outcome
- DecreaseNADPH oxidase activation
- Study
humann: not reported in source
Primary renal proximal tubule cells- Outcome group
- Oxidative stress · Kidney and urinary
- Studied dose
- Dose not stated
Source sentences
Activation of AMPK with 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) mimicked, while inhibition of AMPK with compound C abrogated, the effect of adiponectin on ANG II-induced activation of NADPH oxidase.
3 context sentences(design, population, supporting numbers)
ANG II-induced NADPH oxidase activation and oxidative stress were attenuated by adiponectin and dependent on adipoR1.
Because activation of the renin-angiotensin system (RAS) is a contributor to CKD progression, we tested our hypothesis by studying the interactions between adiponectin and angiotensin II (ANG II) in renal tubular cells.
Primary human renal proximal tubule cells expressed both adiponectin receptor 1 and 2 (adipoR1 and R2).