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Study · In vitro (cells) · 2024

6 results

Exercise ameliorates lipid droplet metabolism disorder by the PLIN2-LIPA axis-mediated lipophagy in mouse model of non-alcoholic fatty liver disease.

Fang C, Liu S, Yang W, Zheng G, Zhou F, Gao X, Qin L, Yang G, Yang J, Zhu G, Wang X, Huang K and 4 more

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Yang X, Wei Y, Peng S, Li L

Biochimica et biophysica acta. Molecular basis of disease2 Feb 2024Cited by 29 (Europe PMC)

PMID38306800 (opens in a new tab)DOI10.1016/j.bbadis.2024.167045 (opens in a new tab)PepBankPUB-38306800
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In palmitic acid-treated HepG2 cells, AICAr increased LIPA mRNA levels.

    In plain wordsIn cells treated with palmitic acid, AICAr increased LIPA mRNA levels.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseLIPA mRNA
    Study

    humann: not reported in source

    palmitic acid-treated HepG2 cells
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Further mechanistic studies demonstrated that adenosine monophosphate-activated protein kinase (AMPK) activator-5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) treatment significantly increased mRNA levels and protein expression of LIPA and LC3II and decreased levels of PLIN2 and P62 in palmit…
  2. 02LabIn vitro (cells)Mechanism

    In palmitic acid-treated HepG2 cells, AICAr increased LIPA protein expression.

    In plain wordsIn cells treated with palmitic acid, AICAr increased LIPA protein expression.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseLIPA protein
    Study

    humann: not reported in source

    palmitic acid-treated HepG2 cells
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Further mechanistic studies demonstrated that adenosine monophosphate-activated protein kinase (AMPK) activator-5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) treatment significantly increased mRNA levels and protein expression of LIPA and LC3II and decreased levels of PLIN2 and P62 in palmit…
  3. 03LabIn vitro (cells)Mechanism

    In palmitic acid-treated HepG2 cells, AICAr increased LC3II mRNA levels.

    In plain wordsIn cells treated with palmitic acid, AICAr increased LC3II mRNA levels.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseLC3II mRNA
    Study

    humann: not reported in source

    palmitic acid-treated HepG2 cells
    Outcome group
    Cell viability and death · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Further mechanistic studies demonstrated that adenosine monophosphate-activated protein kinase (AMPK) activator-5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) treatment significantly increased mRNA levels and protein expression of LIPA and LC3II and decreased levels of PLIN2 and P62 in palmit…
  4. 04LabIn vitro (cells)Mechanism

    In palmitic acid-treated HepG2 cells, AICAr increased LC3II protein expression.

    In plain wordsIn cells treated with palmitic acid, AICAr increased LC3II protein expression.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseLC3II protein
    Study

    humann: not reported in source

    palmitic acid-treated HepG2 cells
    Outcome group
    Cell viability and death · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Further mechanistic studies demonstrated that adenosine monophosphate-activated protein kinase (AMPK) activator-5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) treatment significantly increased mRNA levels and protein expression of LIPA and LC3II and decreased levels of PLIN2 and P62 in palmit…
  5. 05LabIn vitro (cells)Mechanism

    In palmitic acid-treated HepG2 cells, AICAr decreased PLIN2 levels.

    In plain wordsIn cells treated with palmitic acid, AICAr reduced PLIN2 levels.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreasePLIN2 levels
    Study

    humann: not reported in source

    palmitic acid-treated HepG2 cells
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Further mechanistic studies demonstrated that adenosine monophosphate-activated protein kinase (AMPK) activator-5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) treatment significantly increased mRNA levels and protein expression of LIPA and LC3II and decreased levels of PLIN2 and P62 in palmit…
  6. 06LabIn vitro (cells)Mechanism

    In palmitic acid-treated HepG2 cells, AICAr decreased P62 levels.

    In plain wordsIn cells treated with palmitic acid, AICAr reduced P62 levels.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseP62 levels
    Study

    humann: not reported in source

    palmitic acid-treated HepG2 cells
    Outcome group
    Cell viability and death · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Further mechanistic studies demonstrated that adenosine monophosphate-activated protein kinase (AMPK) activator-5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) treatment significantly increased mRNA levels and protein expression of LIPA and LC3II and decreased levels of PLIN2 and P62 in palmit…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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