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Study · In vitro (cells) · 2021

2 results

C1q/tumor necrosis factor-related protein-6 attenuates TNF-α-induced apoptosis in salivary acinar cells via AMPK/SIRT1-modulated miR-34a-5p expression.

Qu LH, Hong X, Zhang Y, Cong X, Xiang RL, Mei M, Su JZ, Wu LL, Yu GY

Journal of cellular physiology5 Jan 2021Cited by 19 (Europe PMC)

PMID33400820 (opens in a new tab)DOI10.1002/jcp.30262 (opens in a new tab)PepBankPUB-33400820
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In salivary cells, AICAR reversed the TNF-α-induced decrease in SIRT1 expression.

    In plain wordsIn cells, AICAR restored SIRT1 expression compared with TNF exposure alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseSIRT1 expression
    Study

    n: not reported in source

    salivary cells exposed to TNF-α
    Comparator
    TNF-α exposure without AICAR
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    whereas activating AMPK by AICAR reversed the decrease in SIRT1 expression and increase in miR-34a-5p expression induced by TNF-α.
  2. 02LabIn vitro (cells)Mechanism

    In salivary cells, AICAR reversed the TNF-α-induced increase in miR-34a-5p expression.

    In plain wordsIn cells, AICAR reduced miR-34a-5p expression compared with TNF exposure alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreasemiR-34a-5p expression
    Study

    n: not reported in source

    salivary cells exposed to TNF-α
    Comparator
    TNF-α exposure without AICAR
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    whereas activating AMPK by AICAR reversed the decrease in SIRT1 expression and increase in miR-34a-5p expression induced by TNF-α.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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