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Study · In vitro (cells) · 2011

3 results

Alternative splice variant PGC-1α-b is strongly induced by exercise in human skeletal muscle.

Norrbom J, Sällstedt EK, Fischer H, Sundberg CJ, Rundqvist H, Gustafsson T

American journal of physiology. Endocrinology and metabolism23 Aug 2011Cited by 59 (Europe PMC)

PMID21862727 (opens in a new tab)DOI10.1152/ajpendo.00119.2011 (opens in a new tab)PepBankPUB-21862727
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cultured human myotubes, AICAR induced PGC-1α-a expression.

    In plain wordsIn cells, AICAR increased PGC-1α-a expression.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePGC-1α-a expression
    Study

    humann: not reported in source

    Cultured human myotubes
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AICAR stimulation of cultured human myotubes induced the expression of PGC-1α-a and PGC-1α-b.
  2. 02LabIn vitro (cells)Mechanism

    In cultured human myotubes, AICAR induced PGC-1α-b expression.

    In plain wordsIn cells, AICAR increased PGC-1α-b expression.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePGC-1α-b expression
    Study

    humann: not reported in source

    Cultured human myotubes
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AICAR stimulation of cultured human myotubes induced the expression of PGC-1α-a and PGC-1α-b.

Studies that did not test the peptide alone1

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 03LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In cultured human myotubes, AICAR combined with norepinephrine produced an additive effect on PGC-1α-b expression.

    In plain wordsIn cells, AICAR with norepinephrine produced an additive effect on PGC-1α-b expression.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAdditive PGC-1α-b expression
    Study

    humann: not reported in source

    Cultured human myotubes
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    AICAR combined with norepinephrine yielded an additive effect on the PGC-1α-b expression only.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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