Lipid-induced insulin resistance is prevented in lean and obese myotubes by AICAR treatment.

Bikman BT, Zheng D, Reed MA, Hickner RC, Houmard JA, Dohm GL

American journal of physiology. Regulatory, integrative and comparative physiology14 Apr 2010Cited by 35 (Europe PMC)

PMID20393162PMCIDPMC2886707DOI10.1152/ajpregu.00190.2009PepBankPUB-20393162

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In lean human myotubes, AICAR prevented the reduction in insulin-stimulated phospho-Akt caused by palmitate.
In plain wordsIn cultured human myotubes from lean donors, AICAR prevented the decrease in insulin-stimulated phospho-Akt caused by palmitate.
Peptide
AICAR (acadesine)
Outcome
IncreaseInsulin-stimulated phospho-Akt preservation
Study
humann: not reported in source
Primary myotubes from lean and morbidly obese donors
Comparator
Palmitate without AICAR
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
We found that a 1-h palmitate incubation in lean myotubes reduced (P < 0.05) insulin-stimulated phosphoprotein kinase B (Akt), Akt substrate 160 (AS160), and inhibitory factor kappaBalpha (IkappaBalpha) mass, all of which were prevented with AICAR inclusion.
1 context sentence(design, population, supporting numbers)
Summary · context
To better understand the divergent response to lipid exposure between lean and obese, we incubated primary human muscle cells from lean [body mass index (BMI) 40 kg/m(2)) subjects with the saturated fatty acid palmitate.
Report a problemFND-2039316201
02LabIn vitro (cells)Mechanism
In lean human myotubes, AICAR prevented the reduction in insulin-stimulated AS160 caused by palmitate.
In plain wordsIn cultured human myotubes from lean donors, AICAR prevented the decrease in insulin-stimulated AS160 caused by palmitate.
Peptide
AICAR (acadesine)
Outcome
IncreaseInsulin-stimulated AS160 preservation
Study
humann: not reported in source
Primary myotubes from lean and morbidly obese donors
Comparator
Palmitate without AICAR
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
We found that a 1-h palmitate incubation in lean myotubes reduced (P < 0.05) insulin-stimulated phosphoprotein kinase B (Akt), Akt substrate 160 (AS160), and inhibitory factor kappaBalpha (IkappaBalpha) mass, all of which were prevented with AICAR inclusion.
1 context sentence(design, population, supporting numbers)
Summary · context
To better understand the divergent response to lipid exposure between lean and obese, we incubated primary human muscle cells from lean [body mass index (BMI) 40 kg/m(2)) subjects with the saturated fatty acid palmitate.
Report a problemFND-2039316202
03LabIn vitro (cells)Mechanism
In lean human myotubes, AICAR prevented the reduction in IkappaBalpha mass caused by palmitate.
In plain wordsIn cultured human myotubes from lean donors, AICAR prevented the decrease in IkappaBalpha caused by palmitate.
Peptide
AICAR (acadesine)
Outcome
IncreaseIkappaBalpha mass preservation
Study
humann: not reported in source
Primary myotubes from lean and morbidly obese donors
Comparator
Palmitate without AICAR
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
We found that a 1-h palmitate incubation in lean myotubes reduced (P < 0.05) insulin-stimulated phosphoprotein kinase B (Akt), Akt substrate 160 (AS160), and inhibitory factor kappaBalpha (IkappaBalpha) mass, all of which were prevented with AICAR inclusion.
1 context sentence(design, population, supporting numbers)
Summary · context
To better understand the divergent response to lipid exposure between lean and obese, we incubated primary human muscle cells from lean [body mass index (BMI) 40 kg/m(2)) subjects with the saturated fatty acid palmitate.
Report a problemFND-2039316203
04LabIn vitro (cells)Mechanism
In myotubes from lean and obese human donors, AICAR improved insulin signaling despite differing responses to lipid exposure.
In plain wordsIn cultured human myotubes from lean and obese donors, AICAR improved insulin signaling during lipid exposure.
Peptide
AICAR (acadesine)
Outcome
IncreaseInsulin signaling
Study
humann: not reported in source
Primary myotubes from lean and morbidly obese donors
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Despite a divergent response to lipid between lean and obese myotubes, AICAR inclusion improved insulin signaling in all myotubes.
1 context sentence(design, population, supporting numbers)
Summary · context
To better understand the divergent response to lipid exposure between lean and obese, we incubated primary human muscle cells from lean [body mass index (BMI) 40 kg/m(2)) subjects with the saturated fatty acid palmitate.
Report a problemFND-2039316204

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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