In doxorubicin-treated Caco2 cells, AICAR increased tight junction protein expression.
In plain wordsIn cells treated with doxorubicin, AICAR increased tight junction protein expression compared with doxorubicin alone.
- Peptide
- AICAR (acadesine)
- Outcome
- IncreaseTight junction protein expression
- Study
n: not reported in source
doxorubicin-treated Caco2 cells- Comparator
- doxorubicin treatment without AICAR
- Outcome group
- Gastrointestinal protection · Gastrointestinal
- Studied dose
- Dose not stated
Source sentences
In vitro studies showed that doxorubicin downregulates tight junction protein expression levels in Caco2 cell, and also AICAR treatment upregulates tight junction protein expression levels.
2 context sentences(design, population, supporting numbers)
In in vitro study, doxorubicin that induces cell senescence was treated to Caco2 cells (colon cell) to mimic aging effect.
After that, 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR), exercise mimic chemical that stimulates AMPK level, was also administered to Caco2 cells.