In L6 myotubes, AICAR abolished lipid-induced mTOR activation.
In plain wordsIn cells exposed to palmitate, AICAR blocked lipid-induced mTOR activation compared with no AICAR.
- Peptide
- AICAR (acadesine)
- Outcome
- DecreaseLipid-induced mTOR activation
- Study
n: not reported in source
L6 myotubes exposed to palmitate- Comparator
- palmitate without AICAR
- Outcome group
- Receptor activity and mechanism · Metabolic and weight
- Studied dose
- 1 mMAs given in this study.
Source sentences
AMPK activation with 1 mM AICAR abolished lipid-induced mTOR activation in vitro.
1 context sentence(design, population, supporting numbers)
In order to determine whether AMPK activation reverses lipid-induced mTOR activation, L6 myotubes were exposed to 0.4 mM palmitate to activate mTORC1/2 in the absence or presence of 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR).