In rat astrocytes exposed to high glucose, AICAR had effects similar to metformin.
In plain wordsIn rat cells exposed to high glucose, AICAR had effects similar to metformin.
- Peptide
- AICAR (acadesine)
- Outcome
- Direction not reportedEffects similar to metformin in high-glucose-treated astrocytes
- Study
ratn: not reported in source
primary astrocytes exposed to high glucose- Comparator
- metformin
- Outcome group
- Receptor activity and mechanism · Nervous system and cognition
- Studied dose
- Dose not stated
Source sentences
Additionally, the effects of AICAR on astrocytes were similar to metformin.
1 context sentence(design, population, supporting numbers)
Therefore, in this study, rat primary astrocytes were preincubated with metformin and AMPK agonist AICAR for 1 h prior to administration of high glucose (33 mM glucose).