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Study · In vitro (cells) · 2024

2 results

Exercise Attenuates Myocardial Ischemia-Reperfusion Injury by Regulating Endoplasmic Reticulum Stress and Mitophagy Through M2 Acetylcholine Receptor.

Chen W, Ma M, Song Y, Hua Y, Jia H, Liu J, Wang Y

Antioxidants & redox signaling21 Jul 2023Cited by 28 (Europe PMC)

PMID37294203 (opens in a new tab)DOI10.1089/ars.2022.0168 (opens in a new tab)PepBankPUB-37294203
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In H9C2 cardiomyocytes, AICAR reduced hypoxia/reoxygenation-induced endoplasmic reticulum stress.

    In plain wordsIn cells, AICAR reduced endoplasmic reticulum stress caused by hypoxia and reoxygenation.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseEndoplasmic reticulum stress
    Study

    n: not reported in source

    H9C2 cardiomyocytes exposed to hypoxia/reoxygenation
    Outcome group
    Gene expression · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At the cellular level, 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) reduced hypoxia/reoxygenation (H/R)-induced ERS through the downregulated expression of PERK/eIF2α/ATF4 pathway proteins in H9C2 cardiomyocytes.
  2. 02LabIn vitro (cells)Mechanism

    In H9C2 cardiomyocytes, AICAR downregulated PERK/eIF2α/ATF4 pathway protein expression during hypoxia/reoxygenation.

    In plain wordsIn cells, AICAR reduced PERK/eIF2α/ATF4 pathway protein expression during hypoxia and reoxygenation.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreasePERK/eIF2α/ATF4 pathway protein expression
    Study

    n: not reported in source

    H9C2 cardiomyocytes exposed to hypoxia/reoxygenation
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At the cellular level, 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) reduced hypoxia/reoxygenation (H/R)-induced ERS through the downregulated expression of PERK/eIF2α/ATF4 pathway proteins in H9C2 cardiomyocytes.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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