In H9c2 cells exposed to high glucose and fat, AICAR increased AMPK expression.
In plain wordsIn cells exposed to high glucose and fat, AICAR increased AMPK expression.
- Peptide
- AICAR (acadesine)
- Outcome
- IncreaseAMPK expression
- Study
n: not reported in source
H9c2 cells exposed to high glucose and fat- Outcome group
- Receptor activity and mechanism · Cardiovascular
- Studied dose
- 1 mMAs given in this study.
Measurements
- AICAR concentration
- 1 mM
- H9c2 cells
Source sentences
Notably, the AMPK activator AICAR (1 mM) was observed to upregulate the expression of AMPK in H9c2 cells after high-glucose and -fat exposure.
1 context sentence(design, population, supporting numbers)
The current study aimed to assess the effectiveness of pharmacological intervention with Platycodin D (PD), a critically active compound isolated from the roots of Platycodon grandiflorum, in mitigating cardiotoxicity in a murine model of type 2 diabetes-induced cardiac injury and in H9c2 cells in vitro.