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Study · In vitro (cells) · 2019

2 results

Thymoquinone Attenuates Acetaminophen Overdose-Induced Acute Liver Injury and Inflammation Via Regulation of JNK and AMPK Signaling Pathway.

Cui BW, Bai T, Yang Y, Zhang Y, Jiang M, Yang HX, Wu M, Liu J, Qiao CY, Zhan ZY, Wu YL, Kang DZ, Lian LH, Nan JX

The American journal of Chinese medicine11 Apr 2019Cited by 24 (Europe PMC)

PMID30974967 (opens in a new tab)DOI10.1142/s0192415x19500307 (opens in a new tab)PepBankPUB-30974967
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In Chang liver cells, AICAR pretreatment reversed APAP-enhanced JNK phosphorylation.

    In plain wordsIn cells, AICAR pretreatment reduced JNK phosphorylation compared with APAP treatment in Chang liver cells.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseJNK phosphorylation
    Study

    humann: not reported in source

    APAP-treated Chang liver cells
    Comparator
    APAP treatment
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated · 24 hAs given in this study (human).

    Source sentences

    Summary
    APAP-enhanced JNK phosphorylation and APAP-suppressed AMPK phosphorylation were also observed in Chang liver cells, and these changes were recovered by pretreatment with TQ, SP600125 and AICAR.
    1 context sentence
    Summary · context
    Human Chang liver cells were incubated with TQ, SP600125 or AICAR in presence of APAP for 24 h.
  2. 02LabIn vitro (cells)Mechanism

    In Chang liver cells, AICAR pretreatment reversed APAP-suppressed AMPK phosphorylation.

    In plain wordsIn cells, AICAR pretreatment restored AMPK phosphorylation compared with APAP treatment in Chang liver cells.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAMPK phosphorylation
    Study

    humann: not reported in source

    APAP-treated Chang liver cells
    Comparator
    APAP treatment
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated · 24 hAs given in this study (human).

    Source sentences

    Summary
    APAP-enhanced JNK phosphorylation and APAP-suppressed AMPK phosphorylation were also observed in Chang liver cells, and these changes were recovered by pretreatment with TQ, SP600125 and AICAR.
    1 context sentence
    Summary · context
    Human Chang liver cells were incubated with TQ, SP600125 or AICAR in presence of APAP for 24 h.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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