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Study · In vitro (cells) · 2019

2 results

Exercise-induced AMPK activation is involved in delay of skeletal muscle senescence.

Yoon KJ, Zhang D, Kim SJ, Lee MC, Moon HY

Biochemical and biophysical research communications23 Mar 2019Cited by 37 (Europe PMC)

PMID30910357 (opens in a new tab)DOI10.1016/j.bbrc.2019.03.086 (opens in a new tab)PepBankPUB-30910357
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In skeletal muscle cells, AICAR pretreatment restored viability compared with doxorubicin alone.

    In plain wordsIn skeletal muscle cells, AICAR pretreatment improved cell survival compared with doxorubicin alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseCell viability
    Study

    n: not reported in source

    Differentiated skeletal muscle cells exposed to doxorubicin
    Comparator
    Doxorubicin alone
    Outcome group
    Aging markers · Musculoskeletal
    Studied dose
    Dose not stated · 3 h pre-incubationAs given in this study.

    Source sentences

    Summary
    Accordingly, cellular viability of skeletal muscle cells was recovered in the cells pre-treated with AICAR then administered doxorubicin as compared to that of doxorubicin-only treatment.
    1 context sentence
    Summary · context
    Pre-incubation for 3 h with AICAR decreased doxorubicin-induced phosphorylation of AMPK in a differentiated skeletal muscle cell line.
  2. 02LabIn vitro (cells)Mechanism

    In differentiated skeletal muscle cells, AICAR pre-incubation decreased doxorubicin-induced AMPK phosphorylation.

    In plain wordsIn skeletal muscle cells, AICAR pretreatment reduced AMPK phosphorylation induced by doxorubicin compared with doxorubicin alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseAMPK phosphorylation
    Study

    n: not reported in source

    Differentiated skeletal muscle cells exposed to doxorubicin
    Comparator
    Doxorubicin alone
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated · 3 h pre-incubationAs given in this study.

    Source sentences

    Summary
    Pre-incubation for 3 h with AICAR decreased doxorubicin-induced phosphorylation of AMPK in a differentiated skeletal muscle cell line.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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