Activation of the metabolic sensor-AMP activated protein kinase reverses impairment of angiogenesis in aging myocardial microvascular endothelial cells. Implications for the aging heart.

Ahluwalia A, Tarnawski AS

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society1 Oct 2011Cited by 21 (Europe PMC)

PMID22204807PepBankPUB-22204807

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In aging rat myocardial microvascular endothelial cells, AICAR increased angiogenesis by 2.1-fold.
In plain wordsIn cells from aging rat hearts, AICAR increased new vessel formation.
Peptide
AICAR (acadesine)
Outcome
IncreaseIn vitro angiogenesis
Study
ratn: not reported in source
Myocardial microvascular endothelial cells from aging Fisher F-344 rats
Outcome group
Angiogenesis · Cardiovascular
Studied dose
Dose not stated
Measurements
Angiogenesis
2.1 fold
AICAR treatment
Source sentences
Summary
Treatment of aging MMECs with AICAR increased in vitro angiogenesis and VEGF mRNA expression by 2.1-fold and 3.7-fold, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
We used MMECs isolated from aging (24 months old) Fisher F-344 rats and treated them with 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), a specific pharmacological stimulator of AMPK.
Report a problemFND-2220480701
02LabIn vitro (cells)Mechanism
In aging rat myocardial microvascular endothelial cells, AICAR increased VEGF mRNA expression by 3.7-fold.
In plain wordsIn cells from aging rat hearts, AICAR increased VEGF gene expression.
Peptide
AICAR (acadesine)
Outcome
IncreaseVEGF mRNA expression
Study
ratn: not reported in source
Myocardial microvascular endothelial cells from aging Fisher F-344 rats
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Measurements
VEGF mRNA expression
3.7 fold
AICAR treatment
Source sentences
Summary
Treatment of aging MMECs with AICAR increased in vitro angiogenesis and VEGF mRNA expression by 2.1-fold and 3.7-fold, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
We used MMECs isolated from aging (24 months old) Fisher F-344 rats and treated them with 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), a specific pharmacological stimulator of AMPK.
Report a problemFND-2220480702
03LabIn vitro (cells)Mechanism
In aging rat myocardial microvascular endothelial cells, AICAR induced MAPK/Erk1/2 phosphorylation.
In plain wordsIn cells from aging rat hearts, AICAR induced MAPK/Erk1/2 phosphorylation.
Peptide
AICAR (acadesine)
Outcome
IncreaseMAPK/Erk1/2 phosphorylation
Study
ratn: not reported in source
Myocardial microvascular endothelial cells from aging Fisher F-344 rats
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Furthermore, AICAR treatment resulted in phosphorylation of MAPK/Erk1/2.
1 context sentence(design, population, supporting numbers)
Summary · context
We used MMECs isolated from aging (24 months old) Fisher F-344 rats and treated them with 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), a specific pharmacological stimulator of AMPK.
Report a problemFND-2220480703

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Version history

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Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

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