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Study · In vitro (cells) · rat · 2017

2 results

AMPK Prevents Palmitic Acid-Induced Apoptosis and Lipid Accumulation in Cardiomyocytes.

Adrian L, Lenski M, Tödter K, Heeren J, Böhm M, Laufs U

Lipids20 Aug 2017Cited by 29 (Europe PMC)

PMID28825205 (opens in a new tab)DOI10.1007/s11745-017-4285-7 (opens in a new tab)PepBankPUB-28825205
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In rat cardiomyocytes, AICAR prevented palmitic acid-induced ADRP upregulation.

    In plain wordsIn cells, AICAR prevented the rise in ADRP caused by palmitic acid compared with palmitic acid alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseADRP upregulation
    Study

    ratn: not reported in source

    rat ventricular cardiomyocytes
    Comparator
    palmitic acid without AICAR
    Outcome group
    Lipids · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AMPK activator AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) prevented up-regulation of ADRP and increased apoptosis by palmitic acid.
    1 context sentence
    Summary · context
    Cell culture studies using rat ventricular cardiomyocytes revealed an increased phosphorylation of AMP activated protein kinase α (AMPKα) to 155 ± 19% and its target acetyl-CoA-carboxylase to 177 ± 23% by CoFA.
  2. 02LabIn vitro (cells)Efficacy outcome

    In rat cardiomyocytes, AICAR prevented palmitic acid-induced increased apoptosis.

    In plain wordsIn cells, AICAR prevented increased cell death caused by palmitic acid compared with palmitic acid alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseApoptosis
    Study

    ratn: not reported in source

    rat ventricular cardiomyocytes
    Comparator
    palmitic acid without AICAR
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AMPK activator AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) prevented up-regulation of ADRP and increased apoptosis by palmitic acid.
    1 context sentence
    Summary · context
    Cell culture studies using rat ventricular cardiomyocytes revealed an increased phosphorylation of AMP activated protein kinase α (AMPKα) to 155 ± 19% and its target acetyl-CoA-carboxylase to 177 ± 23% by CoFA.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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