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Study · In vitro (cells) · 2019

11 results

Chronic AICAR treatment prevents metabolic changes in cardiomyocytes exposed to free fatty acids.

Viglino C, Foglia B, Montessuit C

Pflugers Archiv : European journal of physiology31 May 2019Cited by 17 (Europe PMC)

PMID31152240 (opens in a new tab)DOI10.1007/s00424-019-02285-0 (opens in a new tab)PepBankPUB-31152240
Publisher pagePubMedAsk about this study
Jump to 11 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In FFA-exposed cardiomyocytes, chronic AICAR improved basal glucose transport.

    In plain wordsIn cells exposed to excess fatty acids, AICAR improved basal glucose transport compared with no AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseBasal glucose transport
    Study

    n: not reported in source

    Isolated cultured cardiomyocytes
    Outcome group
    Glycemic control · Cardiovascular
    Studied dose
    Dose not stated · 7 daysAs given in this study.

    Source sentences

    Summary
    Chronic treatment with AICAR improved basal and oligomycin-stimulated glucose transport in FFA-exposed but not in control cardiomyocytes.
    1 context sentence
    Summary · context
    To determine whether chronic low-grade activation of AMP-activated kinase (AMPK) improves substrate metabolism in cardiomyocytes exposed to FFA, isolated cultured cardiomyocytes were exposed for 7 days to FFA ± the AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).
  2. 02LabIn vitro (cells)Efficacy outcome

    In FFA-exposed cardiomyocytes, chronic AICAR improved oligomycin-stimulated glucose transport.

    In plain wordsIn cells exposed to excess fatty acids, AICAR improved stress-stimulated glucose transport compared with no AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseOligomycin-stimulated glucose transport
    Study

    n: not reported in source

    Isolated cultured cardiomyocytes
    Outcome group
    Glycemic control · Cardiovascular
    Studied dose
    Dose not stated · 7 daysAs given in this study.

    Source sentences

    Summary
    Chronic treatment with AICAR improved basal and oligomycin-stimulated glucose transport in FFA-exposed but not in control cardiomyocytes.
    1 context sentence
    Summary · context
    To determine whether chronic low-grade activation of AMP-activated kinase (AMPK) improves substrate metabolism in cardiomyocytes exposed to FFA, isolated cultured cardiomyocytes were exposed for 7 days to FFA ± the AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).
  3. 03LabIn vitro (cells)Efficacy outcome

    In control cardiomyocytes, chronic AICAR did not improve basal glucose transport.

    In plain wordsIn control cells, AICAR did not improve basal glucose transport compared with no AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeBasal glucose transport in control cardiomyocytes
    Study

    n: not reported in source

    Isolated cultured cardiomyocytes
    Outcome group
    Glycemic control · Cardiovascular
    Studied dose
    Dose not stated · 7 daysAs given in this study.

    Source sentences

    Summary
    Chronic treatment with AICAR improved basal and oligomycin-stimulated glucose transport in FFA-exposed but not in control cardiomyocytes.
    1 context sentence
    Summary · context
    To determine whether chronic low-grade activation of AMP-activated kinase (AMPK) improves substrate metabolism in cardiomyocytes exposed to FFA, isolated cultured cardiomyocytes were exposed for 7 days to FFA ± the AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).
  4. 04LabIn vitro (cells)Efficacy outcome

    In control cardiomyocytes, chronic AICAR did not improve oligomycin-stimulated glucose transport.

    In plain wordsIn control cells, AICAR did not improve stress-stimulated glucose transport compared with no AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeOligomycin-stimulated glucose transport in control cardiomyocytes
    Study

    n: not reported in source

    Isolated cultured cardiomyocytes
    Outcome group
    Glycemic control · Cardiovascular
    Studied dose
    Dose not stated · 7 daysAs given in this study.

    Source sentences

    Summary
    Chronic treatment with AICAR improved basal and oligomycin-stimulated glucose transport in FFA-exposed but not in control cardiomyocytes.
    1 context sentence
    Summary · context
    To determine whether chronic low-grade activation of AMP-activated kinase (AMPK) improves substrate metabolism in cardiomyocytes exposed to FFA, isolated cultured cardiomyocytes were exposed for 7 days to FFA ± the AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).
  5. 05LabIn vitro (cells)Efficacy outcome

    In FFA-exposed cardiomyocytes, chronic AICAR restored basal glycolysis.

    In plain wordsIn cells exposed to excess fatty acids, AICAR restored basal glucose breakdown compared with no AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseBasal glycolysis
    Study

    n: not reported in source

    Isolated cultured cardiomyocytes
    Outcome group
    Glycemic control · Cardiovascular
    Studied dose
    Dose not stated · 7 daysAs given in this study.

    Source sentences

    Summary
    Similarly, basal and oligomycin-stimulated glycolysis was reduced in FFA-exposed cardiomyocytes but restored by chronic AICAR treatment.
    1 context sentence
    Summary · context
    To determine whether chronic low-grade activation of AMP-activated kinase (AMPK) improves substrate metabolism in cardiomyocytes exposed to FFA, isolated cultured cardiomyocytes were exposed for 7 days to FFA ± the AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).
  6. 06LabIn vitro (cells)Efficacy outcome

    In FFA-exposed cardiomyocytes, chronic AICAR restored oligomycin-stimulated glycolysis.

    In plain wordsIn cells exposed to excess fatty acids, AICAR restored stress-stimulated glucose breakdown compared with no AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseOligomycin-stimulated glycolysis
    Study

    n: not reported in source

    Isolated cultured cardiomyocytes
    Outcome group
    Glycemic control · Cardiovascular
    Studied dose
    Dose not stated · 7 daysAs given in this study.

    Source sentences

    Summary
    Similarly, basal and oligomycin-stimulated glycolysis was reduced in FFA-exposed cardiomyocytes but restored by chronic AICAR treatment.
    1 context sentence
    Summary · context
    To determine whether chronic low-grade activation of AMP-activated kinase (AMPK) improves substrate metabolism in cardiomyocytes exposed to FFA, isolated cultured cardiomyocytes were exposed for 7 days to FFA ± the AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).
  7. 07LabIn vitro (cells)Mechanism

    In FFA-exposed cardiomyocytes, chronic AICAR reduced fatty acid oxidation.

    In plain wordsIn cells exposed to excess fatty acids, AICAR reduced fatty acid burning compared with no AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseFatty acid oxidation
    Study

    n: not reported in source

    Isolated cultured cardiomyocytes
    Outcome group
    Lipids · Cardiovascular
    Studied dose
    Dose not stated · 7 daysAs given in this study.

    Source sentences

    Summary
    Conversely, fatty acid oxidation was increased in FFA-exposed cardiomyocytes and reduced by chronic AICAR treatment.
    1 context sentence
    Summary · context
    To determine whether chronic low-grade activation of AMP-activated kinase (AMPK) improves substrate metabolism in cardiomyocytes exposed to FFA, isolated cultured cardiomyocytes were exposed for 7 days to FFA ± the AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).
  8. 08LabIn vitro (cells)Mechanism

    In FFA-exposed cardiomyocytes, chronic AICAR induced biogenesis of numerous lipid droplets.

    In plain wordsIn cells exposed to excess fatty acids, AICAR promoted lipid droplet formation.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseLipid droplet biogenesis
    Study

    n: not reported in source

    Isolated cultured cardiomyocytes
    Outcome group
    Lipids · Cardiovascular
    Studied dose
    Dose not stated · 7 daysAs given in this study.

    Source sentences

    Summary
    Chronic AICAR treatment induced in FFA-exposed cardiomyocytes the biogenesis of numerous lipid droplets.
    1 context sentence
    Summary · context
    To determine whether chronic low-grade activation of AMP-activated kinase (AMPK) improves substrate metabolism in cardiomyocytes exposed to FFA, isolated cultured cardiomyocytes were exposed for 7 days to FFA ± the AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).
  9. 09LabIn vitro (cells)Mechanism

    In cardiomyocytes, acute AICAR increased AMPKα phosphorylation on T172.

    In plain wordsIn cells, acute AICAR increased AMPK phosphorylation.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAcute AMPKα phosphorylation
    Study

    n: not reported in source

    Isolated cultured cardiomyocytes
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Curiously, whereas acute treatment of cardiomyocytes with AICAR increased phosphorylation of the AMPKα subunit on T172, a classical marker of AMPK activation, chronic AICAR treatment almost completely obliterated T172 phosphorylation.
    1 context sentence
    Summary · context
    To determine whether chronic low-grade activation of AMP-activated kinase (AMPK) improves substrate metabolism in cardiomyocytes exposed to FFA, isolated cultured cardiomyocytes were exposed for 7 days to FFA ± the AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).
  10. 10LabIn vitro (cells)Mechanism

    In cardiomyocytes, chronic AICAR almost completely obliterated AMPKα T172 phosphorylation.

    In plain wordsIn cells, chronic AICAR almost eliminated AMPK phosphorylation.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseChronic AMPKα phosphorylation
    Study

    n: not reported in source

    Isolated cultured cardiomyocytes
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 7 daysAs given in this study.

    Source sentences

    Summary
    Curiously, whereas acute treatment of cardiomyocytes with AICAR increased phosphorylation of the AMPKα subunit on T172, a classical marker of AMPK activation, chronic AICAR treatment almost completely obliterated T172 phosphorylation.
    1 context sentence
    Summary · context
    To determine whether chronic low-grade activation of AMP-activated kinase (AMPK) improves substrate metabolism in cardiomyocytes exposed to FFA, isolated cultured cardiomyocytes were exposed for 7 days to FFA ± the AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).
  11. 11LabIn vitro (cells)Mechanism

    In FFA-exposed cardiomyocytes, AICAR restored raptor phosphorylation on S792.

    In plain wordsIn cells exposed to excess fatty acids, AICAR restored raptor phosphorylation compared with no AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseRaptor phosphorylation
    Study

    n: not reported in source

    Isolated cultured cardiomyocytes
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 7 daysAs given in this study.

    Source sentences

    Summary
    However, phosphorylation of the AMPK target protein raptor on S792 was reduced in FFA-exposed cardiomyocytes but restored by AICAR treatment.
    1 context sentence
    Summary · context
    To determine whether chronic low-grade activation of AMP-activated kinase (AMPK) improves substrate metabolism in cardiomyocytes exposed to FFA, isolated cultured cardiomyocytes were exposed for 7 days to FFA ± the AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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