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Study · In vitro (cells) · 2011

1 result

AMP-activated protein kinase attenuates Wnt/β-catenin signaling in human osteoblastic Saos-2 cells.

Takatani T, Minagawa M, Takatani R, Kinoshita K, Kohno Y

Molecular and cellular endocrinology8 Apr 2011Cited by 26 (Europe PMC)

PMID21501658 (opens in a new tab)DOI10.1016/j.mce.2011.04.003 (opens in a new tab)PepBankPUB-21501658
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In human osteoblast-like Saos-2 cells, AICAR suppressed Wnt3a-induced TCF-dependent transcriptional activity.

    In plain wordsIn cells, AICAR reduced Wnt3a-induced TCF-dependent gene activity.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseWnt3a-induced TCF-dependent transcription
    Study

    humann: not reported in source

    Osteoblast-like Saos-2 cells
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Chemical activators of AMPK (AICAR [5-aminoimidazole-4-carboxamide riboside], metformin) suppressed Wnt3a-induced TCF-dependent transcriptional activity.
    1 context sentence
    Summary · context
    Using human osteoblast-like Saos-2 cells, we determined whether AMPK modulates Wnt/β-catenin signaling in osteoblasts.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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