MOTS-c studies: 176 papers with results
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- Central and peripheral mechanism of MOTS-c attenuates pain hypersensitivity in a mice model of inflammatory pain.
Wang Z · Neurological research · 2024
Animal study (in vivo) · mouse · 7 results
- Mitochondria-encoded peptide MOTS-c participates in plasma membrane repair by facilitating the translocation of TRIM72 to membrane.
Jia H · Theranostics · 2024
Animal study (in vivo) · mouse · 15 results
- Mitochondria-derived peptide is an effective target for treating streptozotocin induced painful diabetic neuropathy through induction of activated protein kinase/peroxisome proliferator-activated receptor gamma coactivator 1alpha -mediated mitochondrial biogenesis.
Xu L · Molecular pain · 2024
Animal study (in vivo) · mouse · 11 results
- MOTS-c attenuates mitochondrial dysfunction induces pyroptosis and cartilage degradation in osteoarthritis via an Nrf2-Dependent Mechanism.
Li K · Free radical biology & medicine · 2025
Animal study (in vivo) · mouse · 7 results
- Neuroprotective Mechanism of MOTS-c in TBI Mice: Insights from Integrated Transcriptomic and Metabolomic Analyses.
Li F · Drug design, development and therapy · 2024
Animal study (in vivo) · mouse · 9 results
- MOTS-c improves intrinsic muscle mitochondrial bioenergetic health and efficiency in a PGC-1α/AMPK-dependent manner.
Gudiksen A · Free radical biology & medicine · 2026
Animal study (in vivo) · mouse · 8 results
- The impact of mitokine MOTS-c administration on the soleus muscle of rats subjected to a 7-day hindlimb suspension.
Sidorenko DA · Journal of muscle research and cell motility · 2025
Animal study (in vivo) · rat · 10 results
- Mitochondrial peptide MOTS-c suppresses systemic and cardiac inflammasome activation in a diabetic rat model.
Mills AR · Experimental physiology · 2026
Animal study (in vivo) · rat · 7 results
- MOTS-c attenuates cardiac dysfunction following high altitude exposure by promoting mitophagy.
Feng Z · Free radical biology & medicine · 2026
Animal study (in vivo) · mouse · 5 results
- Aerobic exercise and MOTS-c attenuate diabetic myocardial fibrosis via inhibition of the THBS1/TGF-β signaling pathway.
Li Z · Frontiers in endocrinology · 2026
Animal study (in vivo) · 4 results
- MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide.
Rice MC · eLife · 2026
Animal study (in vivo) · mouse · 8 results
- Mitochondrial-derived peptide MOTS-c activates metabolic signaling but blunts reparative function in human mesenchymal stromal cells.
Xing L · Inflammation and regeneration · 2026
Animal study (in vivo) · mouse · 10 results
- MOTS-c, a mitochondrial-derived peptide, ameliorates lysosomal membrane permeability and improves survival of soft tissue transplantation.
Shi J · Autophagy · 2026
Animal study (in vivo) · 8 results
- MOTS-c partially protects against skeletal muscle deterioration in C26 cachexia.
Jamnick NA · Frontiers in medicine · 2026
Animal study (in vivo) · mouse · 12 results
- MOTS-c attenuates hyperoxia-induced neonatal cardiac injury by inhibiting oxeiptosis via maintaining the KEAP1-PGAM5 interaction.
Li SH · Life sciences · 2026
Animal study (in vivo) · mouse · 9 results
- Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction.
Liao Y · Biomedicines · 2026
Animal study (in vivo) · mouse · 26 results
- Mitochondrial-derived peptide MOTS-c targets SLC7A11 to preserve spermatogenesis by suppressing ferroptosis.
Liu S · Free radical biology & medicine · 2026
Animal study (in vivo) · 7 results
- Mitochondria-derived peptide MOTS-c alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice by activating Nrf2 pathway.
Chen D · European journal of pharmacology · 2026
Animal study (in vivo) · mouse · 13 results
- Therapeutic Effects of MOTS-c in the Valproic Acid-Induced Autism Model in Rats: Role of Tetrahydrobiopterin and Brain-Derived Neurotrophic Factor.
Güvenir Seven S · Molecular neurobiology · 2026
Animal study (in vivo) · rat · 8 results
- MOTS-c Protects Against Acetaminophen-induced Liver Injury through the MAPK Signaling Pathway.
Li N · Protein and peptide letters · 2026
Animal study (in vivo) · mouse · 19 results
- A mitochondrial-derived peptide MOTS-c contributes to the protective effect against brain injury associated with LPS-induced sepsis by strengthening the blood-brain barrier's ultrastructure.
Bai Y · The International journal of neuroscience · 2026
Animal study (in vivo) · mouse · 9 results
- MITOCHONDRIA: POWERHOUSE, SLAUGHTERHOUSE, AND SPEAKER OF THE HOUSE
Innovation in aging · 2022
Animal study (in vivo) · mouse · 2 results
- STRESS RESISTANCE AND THE INTEGRATED MITONUCLEAR GENOMES
Lee C · Innovation in aging · 2018
Animal study (in vivo) · mouse · 3 results
- MYOSTATIN MODULATION BY MOTS-C MAY LEAD TO BENEFICIAL EFFECTS IN MUSCLE AND FAT TISSUE
Ligeiro Coelho A · Innovation in aging · 2018
Animal study (in vivo) · mouse · 7 results
- The protective effect of the mitochondrial-derived peptide MOTS-c on LPS-induced septic cardiomyopathy.
Wu J · Acta biochimica et biophysica Sinica · 2023
Other design · 15 results
- MOTS-c preserves mitochondrial subpopulation bioenergetics and genome integrity to attenuate cardiac ischemia reperfusion injury.
Santhanam SS · Molecular biology reports · 2026
Ex vivo tissue · rat · 6 results
- Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction.
Qin Q · International journal of cardiology · 2018
Ex vivo tissue · mouse and rat · 6 results
- Exogenous humanin and MOTS-c function as protective agents against gentamicin-induced hair cell damage.
Waldmann D · Biochemical and biophysical research communications · 2023
Ex vivo tissue · 4 results
- MOTS-c modulates pancreatic islet function in rats and pigs in vitro.
Bień J · Histochemistry and cell biology · 2025
Ex vivo tissue · rat and pig · 4 results
- Exogenous MOTS-c mitigates myocardial ischemia-reperfusion injury: experimental and in silico evidence from rat heart models.
Santhanam SS · Naunyn-Schmiedeberg's archives of pharmacology · 2026
Ex vivo tissue · rat · 25 results
- The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress.
Kim KH · Cell metabolism · 2018
In vitro (cells) · 3 results
- Mitochondrial peptides modulate mitochondrial function during cellular senescence.
Kim SJ · Aging · 2018
In vitro (cells) · 8 results
- MOTS-c interacts synergistically with exercise intervention to regulate PGC-1α expression, attenuate insulin resistance and enhance glucose metabolism in mice via AMPK signaling pathway.
Yang B · Biochimica et biophysica acta. Molecular basis of disease · 2021
In vitro (cells) · 7 results
- MOTS-c improves osteoporosis by promoting osteogenic differentiation of bone marrow mesenchymal stem cells via TGF-β/Smad pathway.
Hu BT · European review for medical and pharmacological sciences · 2018
In vitro (cells) · rat · 3 results
- The Mitochondrial-Derived Peptide MOTS-c Attenuates Oxidative Stress Injury and the Inflammatory Response of H9c2 Cells Through the Nrf2/ARE and NF-κB Pathways.
Shen C · Cardiovascular engineering and technology · 2022
In vitro (cells) · rat · 11 results
- MOTS-c improves osteoporosis by promoting the synthesis of type I collagen in osteoblasts via TGF-β/SMAD signaling pathway.
Che N · European review for medical and pharmacological sciences · 2019
In vitro (cells) · 9 results
- The mitochondrial-derived peptide MOTS-c promotes homeostasis in aged human placenta-derived mesenchymal stem cells in vitro.
Yu WD · Mitochondrion · 2021
In vitro (cells) · 7 results
- Mitofusion is required for MOTS-c induced GLUT4 translocation.
Bhullar KS · Scientific reports · 2021
In vitro (cells) · 9 results
- MOTS-c promotes muscle differentiation in vitro.
García-Benlloch S · Peptides · 2022
In vitro (cells) · mouse · 4 results
- MOTS-c-modified functional self-assembly peptide hydrogels enhance the activity of nucleus pulposus-derived mesenchymal stem cells of intervertebral disc degeneration.
Lin Y · Materials today. Bio · 2025
In vitro (cells) · 13 results
- MOTS-c regulates pancreatic alpha and beta cell functions in vitro.
Bień J · Histochemistry and cell biology · 2024
In vitro (cells) · 7 results
- Effects of MOTS-c on the mitochondrial function of cells harboring 3243 A to G mutant mitochondrial DNA.
Ahn CH · Molecular biology reports · 2020
In vitro (cells) · 8 results
- MOTS-c mimics exercise to combat diabetic liver fibrosis by targeting Keap1-Nrf2-Smad2/3.
Chen F · Scientific reports · 2025
In vitro (cells) · 5 results
- Exploring the therapeutic potential of MOTS-c in age-related macular degeneration: from cellular responses to patient-derived cybrids.
Mohtashami Z · Human cell · 2025
In vitro (cells) · 11 results
- MOTS-c Impact on Muscle Cell Differentiation and Metabolism Across Fiber Types.
Leciejewska N · Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2025
In vitro (cells) · 10 results
- Mitochondrial-derived peptides MOTS-c and humanin attenuate dexamethasone-induced atrophy in human skeletal muscle cells.
Elhusseiny R · Physiological reports · 2026
In vitro (cells) · 9 results
- Circulating Mitochondrial Open Reading Frame of the 12S Ribosomal RNA Type-c Is Higher in Acute Coronary Syndrome and Is a Prognostic Biomarker for Major Cardiac Events in Patients With Acute Myocardial Infarction: A Case-Control Study.
Cao P · Journal of the American Heart Association · 2025
In vitro (cells) · 6 results
- Characterization of the Avian Mitochondrial-Derived Peptide MOTS-c and Its Potential Role as a Metabolic Regulator.
Shu X · Animals : an open access journal from MDPI · 2025
In vitro (cells) · 7 results
- Expression Patterns of MOTS-c in Adrenal Tumors: Results from a Preliminary Study.
Kamiński K · International journal of molecular sciences · 2024
Measured the body's own MOTS-c · 11 results
- Circulating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance.
Du C · Pediatric diabetes · 2018
Measured the body's own MOTS-c · 10 results