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Study · Animal study (in vivo) · mouse · 2024

9 results

Neuroprotective Mechanism of MOTS-c in TBI Mice: Insights from Integrated Transcriptomic and Metabolomic Analyses.

Li F, Jia Y, Fang J, Gong L, Zhang Y, Wei S, Wu L, Jiang P

Drug design, development and therapy15 Jul 2024Cited by 4 (Europe PMC)

PMID39050800 (opens in a new tab)PMCIDPMC11268520 (opens in a new tab)DOI10.2147/dddt.s460265 (opens in a new tab)PepBankPUB-39050800
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study9

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In mice with traumatic brain injury, peripherally administered MOTS‑c entered brain tissue.

    In plain wordsIn mice with brain injury, MOTS‑c given outside the brain reached brain tissue.

    Peptide
    MOTS-c
    Outcome
    Not applicableEntry of peripherally administered MOTS-c into brain tissue
    Study

    mousen: not reported in source

    Traumatic brain injury (TBI)
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · peripheralAs given in this study (mouse).

    Source sentences

    Summary
    and peripheral administration of MOTS-c could enter the brain tissue after TBI.
    1 context sentence
    Summary · context
    Adult male C57BL/6 mice were randomly divided into three groups: control (CON) group, MOTS-c group and TBI group.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with traumatic brain injury, MOTS‑c improved memory impairments.

    In plain wordsIn mice with brain injury, MOTS‑c improved memory problems.

    Peptide
    MOTS-c
    Outcome
    IncreaseMemory function after TBI
    Study

    mousen: not reported in source

    Traumatic brain injury (TBI)
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Behavioral tests revealed that MOTS-c improved memory, learning, and motor function impairments in TBI mice.
    1 context sentence
    Summary · context
    Adult male C57BL/6 mice were randomly divided into three groups: control (CON) group, MOTS-c group and TBI group.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with traumatic brain injury, MOTS‑c improved learning impairments.

    In plain wordsIn mice with brain injury, MOTS‑c improved learning problems.

    Peptide
    MOTS-c
    Outcome
    IncreaseLearning function after TBI
    Study

    mousen: not reported in source

    Traumatic brain injury (TBI)
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Behavioral tests revealed that MOTS-c improved memory, learning, and motor function impairments in TBI mice.
    1 context sentence
    Summary · context
    Adult male C57BL/6 mice were randomly divided into three groups: control (CON) group, MOTS-c group and TBI group.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with traumatic brain injury, MOTS‑c improved motor function impairments.

    In plain wordsIn mice with brain injury, MOTS‑c improved movement problems.

    Peptide
    MOTS-c
    Outcome
    IncreaseMotor function after TBI
    Study

    mousen: not reported in source

    Traumatic brain injury (TBI)
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Behavioral tests revealed that MOTS-c improved memory, learning, and motor function impairments in TBI mice.
    1 context sentence
    Summary · context
    Adult male C57BL/6 mice were randomly divided into three groups: control (CON) group, MOTS-c group and TBI group.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with traumatic brain injury, transcriptomic analysis screened 159 differentially expressed genes.

    In plain wordsIn mice with brain injury, gene analysis found 159 genes with different activity.

    Peptide
    MOTS-c
    Outcome
    Direction not reportedDifferentially expressed genes (transcriptomics)
    Study

    mousen: not reported in source

    Traumatic brain injury (TBI)
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Differentially expressed genes
    159 genes
    transcriptomic analysis

    Source sentences

    Summary
    Additionally, transcriptomic analysis screened 159 differentially expressed genes.
    1 context sentence
    Summary · context
    Adult male C57BL/6 mice were randomly divided into three groups: control (CON) group, MOTS-c group and TBI group.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with traumatic brain injury, metabolomic analysis identified 491 metabolites with significant differences.

    In plain wordsIn mice with brain injury, metabolite analysis found 491 compounds with different levels.

    Peptide
    MOTS-c
    Outcome
    Direction not reportedDifferentially expressed metabolites (metabolomics)
    Study

    mousen: not reported in source

    Traumatic brain injury (TBI)
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Differentially expressed metabolites
    491 metabolites
    metabolomic analysis

    Source sentences

    Summary
    Metabolomic analysis identified 491 metabolites with significant differences.
    1 context sentence
    Summary · context
    Adult male C57BL/6 mice were randomly divided into three groups: control (CON) group, MOTS-c group and TBI group.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with traumatic brain injury, integrated analysis found 14 KEGG pathways, primarily related to metabolic pathways.

    In plain wordsIn mice with brain injury, combined gene and metabolite analysis found 14 pathways, mostly linked to metabolism.

    Peptide
    MOTS-c
    Outcome
    Direction not reportedKEGG pathways in integrated analysis
    Study

    mousen: not reported in source

    Traumatic brain injury (TBI)
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    KEGG pathways
    14 pathways
    integrated transcriptomic and metabolomic analysis

    Source sentences

    Summary
    Integrated analysis found 14 KEGG pathways, primarily related to metabolic pathways.
    1 context sentence
    Summary · context
    Adult male C57BL/6 mice were randomly divided into three groups: control (CON) group, MOTS-c group and TBI group.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mice with traumatic brain injury, several signaling pathways were enriched, including neuroactive ligand-receptor interaction and retrograde endocannabinoid signaling.

    In plain wordsIn mice with brain injury, several signalling pathways were enriched, including neuroactive ligand-receptor interaction and endocannabinoid signalling.

    Peptide
    MOTS-c
    Outcome
    Direction not reportedEnriched signaling pathways
    Study

    mousen: not reported in source

    Traumatic brain injury (TBI)
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Besides, several signaling pathways were enriched, including neuroactive ligand-receptor interaction and retrograde endocannabinoid signaling.
    1 context sentence
    Summary · context
    Adult male C57BL/6 mice were randomly divided into three groups: control (CON) group, MOTS-c group and TBI group.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 09AnimalEndogenous levelAnimal study (in vivo)Other

    In mice with traumatic brain injury, TBI decreased expression of the body's own MOTS‑c.

    In plain wordsIn mice, brain injury lowered the body's own MOTS‑c levels.

    Peptide
    MOTS-c
    Outcome
    DecreaseMOTS-c expression after TBI
    Study

    mousen: not reported in source

    Traumatic brain injury (TBI)
    Outcome group
    Mitochondrial function · Nervous system and cognition

    Source sentences

    Summary
    ELISA kit method showed that TBI resulted in a decrease in the expression of MOTS-c.
    1 context sentence
    Summary · context
    Adult male C57BL/6 mice were randomly divided into three groups: control (CON) group, MOTS-c group and TBI group.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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