Circulating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance.

Du C, Zhang C, Wu W, Liang Y, Wang A, Wu S, Zhao Y, Hou L, Ning Q, Luo X

Pediatric diabetes25 Apr 2018Cited by 77 (Europe PMC)

PMID29691953DOI10.1111/pedi.12685PepBankPUB-29691953

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study10

No result from this study comes from a test of the peptide.

Natural levels measured10

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In children and adolescents, circulating MOTS‑c levels were lower in the obese group than in controls.
In plain wordsIn children and adolescents, the body's own MOTS‑c level was lower in obese participants than in controls.
Peptide
MOTS-c
Outcome
DecreaseCirculating MOTS-c in obese versus control children
Study
n = 97
Comparator
Healthy controls
Outcome group
Endogenous peptide levels · Metabolic and weight
Measurements
MOTS-c level
472.61 ng/mL
obese group
MOTS-c level
561.64 ng/mL
control group
Source sentences
Summary
MOTS-c levels were significantly decreased in the obese group compared with the control group (472.61 ±22.83 vs 561.64 ±19.19 ng/mL, P <.01).
1 context sentence(design, population, supporting numbers)
Summary · context
In this case-control study, 40 obese children and adolescents (27 males) and 57 controls (40 males) were recruited in the Hubei Province of China in 2017.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2969195301
02HumanEndogenous levelObservational studyOther
In male children and adolescents, circulating MOTS‑c levels were lower in obese participants than in male controls.
In plain wordsIn boys and male adolescents, the body's own MOTS‑c level was lower in obese participants than in controls.
Peptide
MOTS-c
Outcome
DecreaseCirculating MOTS-c in obese versus control males
Study
n: not reported in source
Comparator
Healthy male controls
Outcome group
Endogenous peptide levels · Metabolic and weight
Measurements
MOTS-c level
465.26 ng/mL
obese males
MOTS-c level
584.07 ng/mL
control males
Source sentences
Summary
After classification by sex, MOTS-c levels were significantly decreased in obese male children and adolescents compared to their counterparts (465.26 ±24.53 vs 584.07 ±21.18 ng/mL, P <.001)
1 context sentence(design, population, supporting numbers)
Summary · context
In this case-control study, 40 obese children and adolescents (27 males) and 57 controls (40 males) were recruited in the Hubei Province of China in 2017.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2969195302
03HumanEndogenous levelObservational studyOther
In female children and adolescents, circulating MOTS‑c levels did not differ significantly between obese and healthy participants.
In plain wordsIn girls and female adolescents, natural MOTS‑c levels were similar in obese and healthy participants.
Peptide
MOTS-c
Outcome
No significant changeCirculating MOTS-c in obese versus control females
Study
n: not reported in source
Comparator
Healthy female controls
Outcome group
Endogenous peptide levels · Metabolic and weight
Measurements
MOTS-c level
487.89 ng/mL
obese females
MOTS-c level
508.85 ng/mL
control females
Source sentences
Summary
while they were comparable between the obese and healthy female subjects (487.89 ±49.77 vs 508.85 ±38.76 ng/mL, P >.05).
1 context sentence(design, population, supporting numbers)
Summary · context
In this case-control study, 40 obese children and adolescents (27 males) and 57 controls (40 males) were recruited in the Hubei Province of China in 2017.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2969195303
04HumanEndogenous levelObservational studyOther
In the male cohort, circulating MOTS‑c levels correlated negatively with body mass index.
In plain wordsIn boys, higher natural MOTS‑c levels were linked to lower body mass index.
Peptide
MOTS-c
Outcome
DecreaseMOTS-c correlation with BMI (males)
Study
n: not reported in source
Outcome group
Body weight · Metabolic and weight
Source sentences
Summary
Further, MOTS-c levels were negatively correlated with body mass index (BMI), BMI SD score, waist circumference, waist-to-hip ratio, fasting insulin level, homeostasis model assessment of insulin resistance (HOMA-IR), and glycated hemoglobin (HbA1c) in the male cohort.
1 context sentence(design, population, supporting numbers)
Summary · context
In this case-control study, 40 obese children and adolescents (27 males) and 57 controls (40 males) were recruited in the Hubei Province of China in 2017.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2969195304
05HumanEndogenous levelObservational studyOther
In the male cohort, circulating MOTS‑c levels correlated negatively with BMI SD score.
In plain wordsIn boys, higher natural MOTS‑c levels were linked to a lower BMI SD score.
Peptide
MOTS-c
Outcome
DecreaseMOTS-c correlation with BMI SD score (males)
Study
n: not reported in source
Outcome group
Body weight · Metabolic and weight
Source sentences
Summary
Further, MOTS-c levels were negatively correlated with body mass index (BMI), BMI SD score, waist circumference, waist-to-hip ratio, fasting insulin level, homeostasis model assessment of insulin resistance (HOMA-IR), and glycated hemoglobin (HbA1c) in the male cohort.
1 context sentence(design, population, supporting numbers)
Summary · context
In this case-control study, 40 obese children and adolescents (27 males) and 57 controls (40 males) were recruited in the Hubei Province of China in 2017.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2969195305
06HumanEndogenous levelObservational studyOther
In the male cohort, circulating MOTS‑c levels correlated negatively with waist circumference.
In plain wordsIn boys, higher natural MOTS‑c levels were linked to a smaller waist circumference.
Peptide
MOTS-c
Outcome
DecreaseMOTS-c correlation with waist circumference (males)
Study
n: not reported in source
Outcome group
Body weight · Metabolic and weight
Source sentences
Summary
Further, MOTS-c levels were negatively correlated with body mass index (BMI), BMI SD score, waist circumference, waist-to-hip ratio, fasting insulin level, homeostasis model assessment of insulin resistance (HOMA-IR), and glycated hemoglobin (HbA1c) in the male cohort.
1 context sentence(design, population, supporting numbers)
Summary · context
In this case-control study, 40 obese children and adolescents (27 males) and 57 controls (40 males) were recruited in the Hubei Province of China in 2017.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2969195306
07HumanEndogenous levelObservational studyOther
In the male cohort, circulating MOTS‑c levels correlated negatively with waist-to-hip ratio.
In plain wordsIn boys, higher natural MOTS‑c levels were linked to a lower waist-to-hip ratio.
Peptide
MOTS-c
Outcome
DecreaseMOTS-c correlation with waist-to-hip ratio (males)
Study
n: not reported in source
Outcome group
Body weight · Metabolic and weight
Source sentences
Summary
Further, MOTS-c levels were negatively correlated with body mass index (BMI), BMI SD score, waist circumference, waist-to-hip ratio, fasting insulin level, homeostasis model assessment of insulin resistance (HOMA-IR), and glycated hemoglobin (HbA1c) in the male cohort.
1 context sentence(design, population, supporting numbers)
Summary · context
In this case-control study, 40 obese children and adolescents (27 males) and 57 controls (40 males) were recruited in the Hubei Province of China in 2017.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2969195307
08HumanEndogenous levelObservational studyOther
In the male cohort, circulating MOTS‑c levels correlated negatively with fasting insulin level.
In plain wordsIn boys, higher natural MOTS‑c levels were linked to lower fasting insulin.
Peptide
MOTS-c
Outcome
DecreaseMOTS-c correlation with fasting insulin (males)
Study
n: not reported in source
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
Further, MOTS-c levels were negatively correlated with body mass index (BMI), BMI SD score, waist circumference, waist-to-hip ratio, fasting insulin level, homeostasis model assessment of insulin resistance (HOMA-IR), and glycated hemoglobin (HbA1c) in the male cohort.
1 context sentence(design, population, supporting numbers)
Summary · context
In this case-control study, 40 obese children and adolescents (27 males) and 57 controls (40 males) were recruited in the Hubei Province of China in 2017.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2969195308
09HumanEndogenous levelObservational studyOther
In the male cohort, circulating MOTS‑c levels correlated negatively with HOMA-IR.
In plain wordsIn boys, higher natural MOTS‑c levels were linked to lower insulin resistance.
Peptide
MOTS-c
Outcome
DecreaseMOTS-c correlation with HOMA-IR (males)
Study
n: not reported in source
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
Further, MOTS-c levels were negatively correlated with body mass index (BMI), BMI SD score, waist circumference, waist-to-hip ratio, fasting insulin level, homeostasis model assessment of insulin resistance (HOMA-IR), and glycated hemoglobin (HbA1c) in the male cohort.
1 context sentence(design, population, supporting numbers)
Summary · context
In this case-control study, 40 obese children and adolescents (27 males) and 57 controls (40 males) were recruited in the Hubei Province of China in 2017.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2969195309
10HumanEndogenous levelObservational studyOther
In the male cohort, circulating MOTS‑c levels correlated negatively with HbA1c.
In plain wordsIn boys, higher natural MOTS‑c levels were linked to lower HbA1c.
Peptide
MOTS-c
Outcome
DecreaseMOTS-c correlation with HbA1c (males)
Study
n: not reported in source
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
Further, MOTS-c levels were negatively correlated with body mass index (BMI), BMI SD score, waist circumference, waist-to-hip ratio, fasting insulin level, homeostasis model assessment of insulin resistance (HOMA-IR), and glycated hemoglobin (HbA1c) in the male cohort.
1 context sentence(design, population, supporting numbers)
Summary · context
In this case-control study, 40 obese children and adolescents (27 males) and 57 controls (40 males) were recruited in the Hubei Province of China in 2017.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2969195310

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

Keywords

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