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Study · Animal study (in vivo) · 2026

7 results

Mitochondrial-derived peptide MOTS-c targets SLC7A11 to preserve spermatogenesis by suppressing ferroptosis.

Liu S, Ru K, Shen YJ, Yan Y, Zhu C, Wang H, Xu Y, Wang X, Yang H, Zhao S, Gong Y, Tian Y, Qian A, Yang H, Chen Z

Free radical biology & medicine31 Mar 2026

PMID41933740 (opens in a new tab)DOI10.1016/j.freeradbiomed.2026.03.074 (opens in a new tab)PepBankPUB-41933740
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    Exogenous MOTS‑c ameliorated spermatogenic impairment induced by mechanical stress in a microgravity model.

    In plain wordsIn a lab model of mechanical stress, added MOTS‑c reduced damage to sperm production.

    Peptide
    MOTS-c
    Outcome
    DecreaseSpermatogenic impairment
    Study

    n: not reported in source

    Microgravity model of mechanical stress
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, exogenous MOTS-c ameliorated spermatogenic impairment by suppressing oxidative stress and ferroptosis induced by mechanical stress.
    1 context sentence
    Summary · context
    Spermatogenic dysfunction, including decreased sperm concentration, disrupted seminiferous tubule architecture, and a reduction in spermatogonia, was induced by mechanical stress through microgravity model.
  2. 02AnimalAnimal study (in vivo)Mechanism

    Exogenous MOTS‑c suppressed oxidative stress induced by mechanical stress in a microgravity model.

    In plain wordsIn a lab model of mechanical stress, added MOTS‑c reduced oxidative stress.

    Peptide
    MOTS-c
    Outcome
    DecreaseOxidative stress under mechanical stress
    Study

    n: not reported in source

    Microgravity model of mechanical stress
    Outcome group
    Oxidative stress · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, exogenous MOTS-c ameliorated spermatogenic impairment by suppressing oxidative stress and ferroptosis induced by mechanical stress.
  3. 03AnimalAnimal study (in vivo)Mechanism

    Exogenous MOTS‑c suppressed ferroptosis induced by mechanical stress in a microgravity model.

    In plain wordsIn a lab model of mechanical stress, added MOTS‑c reduced a form of cell death called ferroptosis.

    Peptide
    MOTS-c
    Outcome
    DecreaseFerroptosis under mechanical stress
    Study

    n: not reported in source

    Microgravity model of mechanical stress
    Outcome group
    Cell viability and death · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, exogenous MOTS-c ameliorated spermatogenic impairment by suppressing oxidative stress and ferroptosis induced by mechanical stress.
  4. 04AnimalAnimal study (in vivo)Mechanism

    Under mechanical stress, MOTS‑c enhanced protection against spermatogenic impairment by increasing SLC7A11 levels.

    In plain wordsIn a lab model of mechanical stress, MOTS‑c protected sperm production partly by raising SLC7A11.

    Peptide
    MOTS-c
    Outcome
    IncreaseSLC7A11 level and protection of spermatogenesis
    Study

    n: not reported in source

    Microgravity model of mechanical stress
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, MOTS-c enhanced the protection against spermatogenic impairment by increasing SLC7A11 levels under mechanical stress.
  5. 05LabOther designMechanism

    SLC7A11, a key ferroptosis molecule, was identified as a target of MOTS‑c.

    In plain wordsIn lab work, MOTS‑c was found to act on SLC7A11, a protein involved in ferroptosis cell death.

    Peptide
    MOTS-c
    Outcome
    Not applicableSLC7A11 as a target of MOTS-c
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Solute Carrier Family 7 Member 11 (SLC7A11), a key molecule in ferroptosis, was identified as a target of MOTS-c.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 06HumanEndogenous levelObservational studyOther

    Serum MOTS‑c was significantly lower in patients with oligoasthenozoospermia.

    In plain wordsMen with low sperm count and motility had lower levels of the body's own MOTS‑c in blood.

    Peptide
    MOTS-c
    Outcome
    DecreaseSerum MOTS-c in oligoasthenozoospermia
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    MOTS-c levels were significantly reduced in the serum of patients with oligoasthenozoospermia

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  2. 07HumanEndogenous levelObservational studyOther

    In patients with oligoasthenozoospermia, serum MOTS‑c levels correlated with semen quality parameters.

    In plain wordsIn men with low sperm count and motility, natural MOTS‑c levels were linked to semen quality.

    Peptide
    MOTS-c
    Outcome
    Not applicableSerum MOTS-c and semen quality
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    This study first demonstrated that MOTS-c levels were significantly reduced in the serum of patients with oligoasthenozoospermia, and these levels correlated with semen quality parameters.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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