Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction.

Qin Q, Delrio S, Wan J, Jay Widmer R, Cohen P, Lerman LO, Lerman A

International journal of cardiology6 Dec 2017Cited by 85 (Europe PMC)

PMID29242099DOI10.1016/j.ijcard.2017.12.001PepBankPUB-29242099

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueEfficacy outcome
In aortic rings from rats or renal artery stenosis mice, MOTS‑c had no direct vasoactive effect.
In plain wordsIn lab tests on rodent aortic rings, MOTS‑c alone did not widen or narrow the vessels.
Peptide
MOTS-c
Outcome
No significant changeDirect vasoactive effect of MOTS-c
Study
rat, mousen: not reported in source
aortic rings from rats and renal artery stenosis mice
Outcome group
Lung injury and fibrosis · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Although MOTS-c did not have direct vasoactive effects
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of MOTS-c on vascular reactivity was assessed in organ chambers using aortic rings collected from rats and renal artery stenosis (RAS) mice.
Report a problemFND-2924209904
02LabEx vivo tissueEfficacy outcome
Pretreating rat aortic rings with MOTS‑c improved vessel responsiveness to acetylcholine compared with untreated vessels.
In plain wordsIn lab tests, rat vessels pretreated with MOTS‑c responded better to acetylcholine than vessels without MOTS‑c.
Peptide
MOTS-c
Outcome
IncreaseAcetylcholine responsiveness in rat aortic rings
Study
ratn: not reported in source
aortic rings
Comparator
Vessels without MOTS-c pretreatment
Outcome group
Lung injury and fibrosis · Cardiovascular
Studied dose
2 µg/mlAs given in this study (rat).
Measurements
MOTS-c concentration
2 μg/ml
pretreatment
Source sentences
Summary
pretreating aortic rings from rats or RAS mice with MOTS-c (2μg/ml) improved vessel responsiveness to ACh compared with vessels without MOTS-c treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of MOTS-c on vascular reactivity was assessed in organ chambers using aortic rings collected from rats and renal artery stenosis (RAS) mice.
Report a problemFND-2924209905
03LabEx vivo tissueEfficacy outcome
Pretreating aortic rings from renal artery stenosis mice with MOTS‑c improved vessel responsiveness to acetylcholine compared with untreated vessels.
In plain wordsIn lab tests, mouse vessels pretreated with MOTS‑c responded better to acetylcholine than vessels without MOTS‑c.
Peptide
MOTS-c
Outcome
IncreaseAcetylcholine responsiveness in RAS mouse aortic rings
Study
mousen: not reported in source
aortic rings from renal artery stenosis mice
Comparator
Vessels without MOTS-c pretreatment
Outcome group
Lung injury and fibrosis · Cardiovascular
Studied dose
2 µg/mlAs given in this study (mouse).
Measurements
MOTS-c concentration
2 μg/ml
pretreatment
Source sentences
Summary
pretreating aortic rings from rats or RAS mice with MOTS-c (2μg/ml) improved vessel responsiveness to ACh compared with vessels without MOTS-c treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of MOTS-c on vascular reactivity was assessed in organ chambers using aortic rings collected from rats and renal artery stenosis (RAS) mice.
Report a problemFND-2924209906

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

04HumanEndogenous levelObservational studyOther
In patients with recurrent angina and no structural coronary lesions, plasma MOTS‑c levels were lower in those with coronary endothelial dysfunction than in those with normal endothelial function.
In plain wordsIn patients with chest pain and open coronary arteries, the body's own MOTS‑c level was lower in those with endothelial dysfunction.
Peptide
MOTS-c
Outcome
DecreasePlasma MOTS-c in endothelial dysfunction
Study
n = 40
Comparator
Patients with normal endothelial function
Outcome group
Endogenous peptide levels · Cardiovascular
Source sentences
Summary
MOTS-c plasma levels were lower in patients with ED compared with patients with normal endothelial function (p=0.007).
1 context sentence(design, population, supporting numbers)
Summary · context
Forty patients undergoing coronary angiography and endothelial function testing for clinical indications of recurrent angina with no structural coronary lesions were included in the study. They were divided into two groups based on coronary blood flow response to intracoronary acetylcholine (ACh) as…
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2924209901
05HumanEndogenous levelObservational studyOther
In these patients, plasma MOTS‑c levels correlated positively with microvascular coronary endothelial function.
In plain wordsIn these patients, higher natural MOTS‑c levels were linked to better microvascular endothelial function.
Peptide
MOTS-c
Outcome
IncreasePlasma MOTS-c correlation with microvascular endothelial function
Study
n = 40
Outcome group
Endogenous peptide levels · Cardiovascular
Source sentences
Summary
plasma MOTS-c levels were positively correlated with microvascular (p=0.01)
1 context sentence(design, population, supporting numbers)
Summary · context
Forty patients undergoing coronary angiography and endothelial function testing for clinical indications of recurrent angina with no structural coronary lesions were included in the study. They were divided into two groups based on coronary blood flow response to intracoronary acetylcholine (ACh) as…
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2924209902
06HumanEndogenous levelObservational studyOther
In these patients, plasma MOTS‑c levels correlated positively with epicardial coronary endothelial function.
In plain wordsIn these patients, higher natural MOTS‑c levels were linked to better epicardial coronary endothelial function.
Peptide
MOTS-c
Outcome
IncreasePlasma MOTS-c correlation with epicardial endothelial function
Study
n = 40
Outcome group
Endogenous peptide levels · Cardiovascular
Source sentences
Summary
Furthermore, plasma MOTS-c levels were positively correlated with microvascular (p=0.01) and epicardial (p=0.02) coronary endothelial function.
1 context sentence(design, population, supporting numbers)
Summary · context
Forty patients undergoing coronary angiography and endothelial function testing for clinical indications of recurrent angina with no structural coronary lesions were included in the study. They were divided into two groups based on coronary blood flow response to intracoronary acetylcholine (ACh) as…
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2924209903

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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