Circulating Mitochondrial Open Reading Frame of the 12S Ribosomal RNA Type-c Is Higher in Acute Coronary Syndrome and Is a Prognostic Biomarker for Major Cardiac Events in Patients With Acute Myocardial Infarction: A Case-Control Study.

Cao P, Wang B, Zhang N, Yang J, Tong Q, Gong Z

Journal of the American Heart Association10 Dec 2025Cited by 1 (Europe PMC)

PMID41368821PMCIDPMC12826893DOI10.1161/jaha.125.041905PepBankPUB-41368821

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study6

1 result from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In vitro, MOTS‑c treatment reduced hypoxia-induced oxidative stress through activating antioxidants.
In plain wordsIn lab tests, MOTS‑c treatment lowered oxidative stress caused by low oxygen.
Peptide
MOTS-c
Outcome
DecreaseHypoxia-induced oxidative stress with MOTS-c treatment
Study
n: not reported in source
Outcome group
Mitochondrial function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
MOTS-c treatment reduces hypoxia-induced oxidative stress through activating antioxidants.
Report a problemFND-4136882106

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

02HumanEndogenous levelObservational studyOther
In patients with acute coronary syndrome, serum MOTS‑c levels were higher than in normal controls.
In plain wordsIn people with acute coronary syndrome, the body's own MOTS‑c levels were higher than in people without it.
Peptide
MOTS-c
Outcome
IncreaseSerum MOTS-c in acute coronary syndrome versus controls
Study
n = 400
Comparator
Normal controls
Outcome group
Mitochondrial function · Cardiovascular
Source sentences
Summary
The serum levels of MOTS-c and thiobarbituric acid reactive substances were higher in patients with acute coronary syndrome
1 context sentence(design, population, supporting numbers)
Summary · context
A total of 400 subjects were recruited and divided into 3 groups: normal controls, unstable angina, and acute myocardial infarction, based on the clinical data and angiography results.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4136882101
03HumanEndogenous levelObservational studyOther
In patients with acute coronary syndrome, serum MOTS‑c correlated positively with thiobarbituric acid reactive substances.
In plain wordsIn people with acute coronary syndrome, higher body's own MOTS‑c levels were linked to higher oxidative stress markers.
Peptide
MOTS-c
Outcome
IncreaseCorrelation of MOTS-c with TBARS
Study
n = 400
Outcome group
Mitochondrial function · Cardiovascular
Source sentences
Summary
there was a positive correlation between MOTS-c and thiobarbituric acid reactive substances.
1 context sentence(design, population, supporting numbers)
Summary · context
A total of 400 subjects were recruited and divided into 3 groups: normal controls, unstable angina, and acute myocardial infarction, based on the clinical data and angiography results.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4136882102
04HumanEndogenous levelObservational studyOther
In the general population studied, serum MOTS‑c predicted the occurrence of unstable angina and acute myocardial infarction with a sensitivity of 0.890 and an area under the curve of 0.739.
In plain wordsIn people studied, the body's own MOTS‑c level helped to identify unstable angina and heart attack.
Peptide
MOTS-c
Outcome
Not applicableDiagnostic sensitivity of MOTS-c for unstable angina and acute MI
Study
n = 400
Outcome group
Mitochondrial function · Cardiovascular
Measurements
sensitivity
0.89 NA
unstable angina and AMI
AUC
0.739 NA
unstable angina and AMI
Source sentences
Summary
In addition, MOTS-c levels showed a high sensitivity of 0.890 (cutoff value, 326.65 [95% CI, 253.41-631.84]; area under the curve, 0.739 [95% CI, 0.647-0.832], P<0.001) in predicting the occurrence of unstable angina and acute myocardial infarction in the general population.
1 context sentence(design, population, supporting numbers)
Summary · context
A total of 400 subjects were recruited and divided into 3 groups: normal controls, unstable angina, and acute myocardial infarction, based on the clinical data and angiography results.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4136882103
05HumanEndogenous levelObservational studyOther
In patients with acute myocardial infarction, the MOTS‑c/TBARS ratio predicted major adverse cardiac events with a sensitivity of 0.800, specificity of 0.667 and area under the curve of 0.718.
In plain wordsIn people with heart attack, a ratio of the body's own MOTS‑c to an oxidative stress marker predicted later heart events.
Peptide
MOTS-c
Outcome
Not applicableMOTS-c/TBARS ratio predicting MACE in acute MI
Study
n: not reported in source
Outcome group
Cardiovascular events · Cardiovascular
Measurements
sensitivity
0.8 NA
MACE in AMI
specificity
0.667 NA
MACE in AMI
AUC
0.718 NA
MACE in AMI
Source sentences
Summary
Our data also showed that MOTS-c/thiobarbituric acid reactive substances levels could be used to predict major adverse cardiac events in the group with acute myocardial infarction, with a sensitivity of 0.800 and specificity of 0.667 (cutoff value, 48.26 ng/umol [95% CI, 45.43-90.16 ng/umol]; area u…
1 context sentence(design, population, supporting numbers)
Summary · context
A total of 400 subjects were recruited and divided into 3 groups: normal controls, unstable angina, and acute myocardial infarction, based on the clinical data and angiography results.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4136882104
06LabEndogenous levelIn vitro (cells)Mechanism
In vitro, oxidative stress induced MOTS‑c levels.
In plain wordsIn lab tests, oxidative stress raised the cells' own MOTS‑c levels.
Peptide
MOTS-c
Outcome
IncreaseMOTS-c levels induced by oxidative stress
Study
n: not reported in source
Outcome group
Mitochondrial function · Cardiovascular
Source sentences
Summary
In vitro studies demonstrated that oxidative stress induces MOTS-c levels
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4136882105

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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