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Study · Animal study (in vivo) · mouse · 2022

2 results

MITOCHONDRIA: POWERHOUSE, SLAUGHTERHOUSE, AND SPEAKER OF THE HOUSE

The source lists no authors.

Innovation in aging1 Nov 2022

PMCIDPMC9766544 (opens in a new tab)PepBankPUB-91549920
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Summary

Abstract The nuclear and mitochondrial genomes have co-evolved since the union forged 1-2 billion years ago between our ancestral cell and free-living bacteria. The bi-genomic system is coordinated by close communication between the two genome-possessing organelles. More recently, peptides that are encoded in the mitochondrial genome have been identified and shown to communicate mitochondrial messages. In this symposium, I will discuss MOTS-c as a mitochondrial-encoded communication factor in the context of aging. MOTS-c can translocate to the nucleus under metabolic stress to directly regulate adaptive nuclear gene expression. In humans, MOTS-c levels increase in skeletal muscle and in circulation upon exercise. In mice, MOTS-c treatment significantly reversed physical decline in aged mice (22 mo.), including doubling in treadmill running time. Studies from our lab and others point to a novel class of mitochondrial-encoded longevity genes that coordinate cellular homeostasis.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aged mice (22 months), MOTS‑c treatment significantly reversed physical decline.

    In plain wordsIn old mice, MOTS‑c treatment reversed their decline in physical ability.

    Peptide
    MOTS-c
    Outcome
    DecreasePhysical decline in aged mice
    Study

    mousen: not reported in source

    Outcome group
    Exercise and physical function · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In mice, MOTS-c treatment significantly reversed physical decline in aged mice (22 mo.), including doubling in treadmill running time.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In aged mice (22 months), MOTS‑c treatment doubled treadmill running time.

    In plain wordsIn old mice, MOTS‑c treatment doubled the time they could run on a treadmill.

    Peptide
    MOTS-c
    Outcome
    IncreaseTreadmill running time in aged mice
    Study

    mousen: not reported in source

    Outcome group
    Exercise and physical function · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    including doubling in treadmill running time.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

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