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Study · In vitro (cells) · 2018

3 results

The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress.

Kim KH, Son JM, Benayoun BA, Lee C

Cell metabolism5 Jul 2018Cited by 259 (Europe PMC)

PMID29983246 (opens in a new tab)PMCIDPMC6185997 (opens in a new tab)DOI10.1016/j.cmet.2018.06.008 (opens in a new tab)PepBankPUB-29983246
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cells under metabolic stress, MOTS‑c translocated to the nucleus and regulated nuclear gene expression in an AMPK-dependent manner.

    In plain wordsIn cells under metabolic stress, MOTS‑c moved into the nucleus and changed gene activity, and this depended on AMPK.

    Peptide
    MOTS-c
    Outcome
    Not applicableNuclear translocation after metabolic stress
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, we show that MOTS-c, a peptide encoded in the mitochondrial genome, translocates to the nucleus and regulates nuclear gene expression following metabolic stress in a 5'-adenosine monophosphate-activated protein kinase (AMPK)-dependent manner.
  2. 02LabIn vitro (cells)Mechanism

    In the nucleus, MOTS‑c regulated a broad range of genes in response to glucose restriction, including genes with antioxidant response elements.

    In plain wordsIn cells, MOTS‑c changed the activity of many genes during glucose restriction, including antioxidant response genes.

    Peptide
    MOTS-c
    Outcome
    Direction not reportedNuclear gene regulation during glucose restriction
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the nucleus, MOTS-c regulated a broad range of genes in response to glucose restriction, including those with antioxidant response elements (ARE)
  3. 03LabIn vitro (cells)Mechanism

    In cells, nuclear MOTS‑c interacted with ARE-regulating stress-responsive transcription factors such as NFE2L2/NRF2.

    In plain wordsIn cells, MOTS‑c in the nucleus interacted with stress-response proteins that control gene activity, such as NRF2.

    Peptide
    MOTS-c
    Outcome
    Not applicableInteraction with stress-responsive transcription factors
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and interacted with ARE-regulating stress-responsive transcription factors, such as nuclear factor erythroid 2-related factor 2 (NFE2L2/NRF2).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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