A mitochondrial-derived peptide MOTS-c contributes to the protective effect against brain injury associated with LPS-induced sepsis by strengthening the blood-brain barrier's ultrastructure.

Bai Y, Wu H, Wang X, Guo Y, Gong B, Dong B, Yu Y

The International journal of neuroscience5 Aug 2025

PMID40753494DOI10.1080/00207454.2025.2542883PepBankPUB-40753494

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In mice with LPS-induced sepsis, MOTS‑c treatment increased the survival rate.
In plain wordsIn mice with LPS-induced sepsis, MOTS‑c raised survival compared with LPS alone.
Peptide
MOTS-c
Outcome
IncreaseSurvival rate
Study
mousen: not reported in source
LPS-induced sepsis
Comparator
LPS alone
Outcome group
Mortality · Whole body
Studied dose
20 mg/kgAs given in this study (mouse).
Source sentences
Summary
MOTS-c treatment increased the survival rate, decreased the MSS score, alleviated brain tissue damage, downregulated the expression of inflammatory factors, reversed the increase in BBB permeability, upregulated the expression of BBB-related proteins and CD31/PDGFRβ, decreased the expression of GFAP…
2 context sentences(design, population, supporting numbers)
Summary · context
The mice were divided into four groups: Control, Control + MOTS-c, LPS, and LPS + MOTS-c groups.
Summary · context
The mice in the latter two groups received MOTS-c (20 mg/kg) four hours before model establishment.
Report a problemFND-4075349401
02AnimalAnimal study (in vivo)Efficacy outcome
In mice with LPS-induced sepsis, MOTS‑c treatment decreased the murine sepsis score.
In plain wordsIn mice with LPS-induced sepsis, MOTS‑c lowered the sickness score compared with LPS alone.
Peptide
MOTS-c
Outcome
DecreaseMurine sepsis score
Study
mousen: not reported in source
LPS-induced sepsis
Comparator
LPS alone
Outcome group
Mortality · Whole body
Studied dose
20 mg/kgAs given in this study (mouse).
Source sentences
Summary
MOTS-c treatment increased the survival rate, decreased the MSS score, alleviated brain tissue damage, downregulated the expression of inflammatory factors, reversed the increase in BBB permeability, upregulated the expression of BBB-related proteins and CD31/PDGFRβ, decreased the expression of GFAP…
2 context sentences(design, population, supporting numbers)
Summary · context
The mice were divided into four groups: Control, Control + MOTS-c, LPS, and LPS + MOTS-c groups.
Summary · context
The mice in the latter two groups received MOTS-c (20 mg/kg) four hours before model establishment.
Report a problemFND-4075349402
03AnimalAnimal study (in vivo)Efficacy outcome
In mice with LPS-induced sepsis, MOTS‑c treatment alleviated brain tissue damage.
In plain wordsIn mice with LPS-induced sepsis, MOTS‑c reduced brain tissue damage compared with LPS alone.
Peptide
MOTS-c
Outcome
DecreaseBrain tissue damage
Study
mousen: not reported in source
LPS-induced sepsis
Comparator
LPS alone
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
20 mg/kgAs given in this study (mouse).
Source sentences
Summary
MOTS-c treatment increased the survival rate, decreased the MSS score, alleviated brain tissue damage, downregulated the expression of inflammatory factors, reversed the increase in BBB permeability, upregulated the expression of BBB-related proteins and CD31/PDGFRβ, decreased the expression of GFAP…
2 context sentences(design, population, supporting numbers)
Summary · context
The mice were divided into four groups: Control, Control + MOTS-c, LPS, and LPS + MOTS-c groups.
Summary · context
The mice in the latter two groups received MOTS-c (20 mg/kg) four hours before model establishment.
Report a problemFND-4075349403
04AnimalAnimal study (in vivo)Mechanism
In mice with LPS-induced sepsis, MOTS‑c treatment downregulated the expression of inflammatory factors.
In plain wordsIn mice with LPS-induced sepsis, MOTS‑c lowered inflammation signals compared with LPS alone.
Peptide
MOTS-c
Outcome
DecreaseInflammatory factor expression
Study
mousen: not reported in source
LPS-induced sepsis
Comparator
LPS alone
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
20 mg/kgAs given in this study (mouse).
Source sentences
Summary
MOTS-c treatment increased the survival rate, decreased the MSS score, alleviated brain tissue damage, downregulated the expression of inflammatory factors, reversed the increase in BBB permeability, upregulated the expression of BBB-related proteins and CD31/PDGFRβ, decreased the expression of GFAP…
2 context sentences(design, population, supporting numbers)
Summary · context
The mice were divided into four groups: Control, Control + MOTS-c, LPS, and LPS + MOTS-c groups.
Summary · context
The mice in the latter two groups received MOTS-c (20 mg/kg) four hours before model establishment.
Report a problemFND-4075349404
05AnimalAnimal study (in vivo)Efficacy outcome
In mice with LPS-induced sepsis, MOTS‑c treatment reversed the increase in blood-brain barrier permeability.
In plain wordsIn mice with LPS-induced sepsis, MOTS‑c reversed a leak in the blood-brain barrier compared with LPS alone.
Peptide
MOTS-c
Outcome
DecreaseBlood-brain barrier permeability
Study
mousen: not reported in source
LPS-induced sepsis
Comparator
LPS alone
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
20 mg/kgAs given in this study (mouse).
Source sentences
Summary
MOTS-c treatment increased the survival rate, decreased the MSS score, alleviated brain tissue damage, downregulated the expression of inflammatory factors, reversed the increase in BBB permeability, upregulated the expression of BBB-related proteins and CD31/PDGFRβ, decreased the expression of GFAP…
2 context sentences(design, population, supporting numbers)
Summary · context
The mice were divided into four groups: Control, Control + MOTS-c, LPS, and LPS + MOTS-c groups.
Summary · context
The mice in the latter two groups received MOTS-c (20 mg/kg) four hours before model establishment.
Report a problemFND-4075349405
06AnimalAnimal study (in vivo)Mechanism
In mice with LPS-induced sepsis, MOTS‑c treatment upregulated the expression of blood-brain barrier-related proteins.
In plain wordsIn mice with LPS-induced sepsis, MOTS‑c raised proteins that support the blood-brain barrier.
Peptide
MOTS-c
Outcome
IncreaseBlood-brain barrier-related proteins
Study
mousen: not reported in source
LPS-induced sepsis
Comparator
LPS alone
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
20 mg/kgAs given in this study (mouse).
Source sentences
Summary
MOTS-c treatment increased the survival rate, decreased the MSS score, alleviated brain tissue damage, downregulated the expression of inflammatory factors, reversed the increase in BBB permeability, upregulated the expression of BBB-related proteins and CD31/PDGFRβ, decreased the expression of GFAP…
2 context sentences(design, population, supporting numbers)
Summary · context
The mice were divided into four groups: Control, Control + MOTS-c, LPS, and LPS + MOTS-c groups.
Summary · context
The mice in the latter two groups received MOTS-c (20 mg/kg) four hours before model establishment.
Report a problemFND-4075349406
07AnimalAnimal study (in vivo)Mechanism
In mice with LPS-induced sepsis, MOTS‑c treatment upregulated the expression of CD31/PDGFRβ.
In plain wordsIn mice with LPS-induced sepsis, MOTS‑c raised CD31/PDGFRβ, markers of brain blood vessel cells.
Peptide
MOTS-c
Outcome
IncreaseCD31/PDGFRβ expression
Study
mousen: not reported in source
LPS-induced sepsis
Comparator
LPS alone
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
20 mg/kgAs given in this study (mouse).
Source sentences
Summary
MOTS-c treatment increased the survival rate, decreased the MSS score, alleviated brain tissue damage, downregulated the expression of inflammatory factors, reversed the increase in BBB permeability, upregulated the expression of BBB-related proteins and CD31/PDGFRβ, decreased the expression of GFAP…
2 context sentences(design, population, supporting numbers)
Summary · context
The mice were divided into four groups: Control, Control + MOTS-c, LPS, and LPS + MOTS-c groups.
Summary · context
The mice in the latter two groups received MOTS-c (20 mg/kg) four hours before model establishment.
Report a problemFND-4075349407
08AnimalAnimal study (in vivo)Mechanism
In mice with LPS-induced sepsis, MOTS‑c treatment decreased the expression of GFAP/Iba-1/MMP-9.
In plain wordsIn mice with LPS-induced sepsis, MOTS‑c lowered GFAP, Iba-1 and MMP-9, markers linked to brain injury.
Peptide
MOTS-c
Outcome
DecreaseGFAP/Iba-1/MMP-9 expression
Study
mousen: not reported in source
LPS-induced sepsis
Comparator
LPS alone
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
20 mg/kgAs given in this study (mouse).
Source sentences
Summary
MOTS-c treatment increased the survival rate, decreased the MSS score, alleviated brain tissue damage, downregulated the expression of inflammatory factors, reversed the increase in BBB permeability, upregulated the expression of BBB-related proteins and CD31/PDGFRβ, decreased the expression of GFAP…
2 context sentences(design, population, supporting numbers)
Summary · context
The mice were divided into four groups: Control, Control + MOTS-c, LPS, and LPS + MOTS-c groups.
Summary · context
The mice in the latter two groups received MOTS-c (20 mg/kg) four hours before model establishment.
Report a problemFND-4075349408
09AnimalAnimal study (in vivo)Mechanism
In mice with LPS-induced sepsis, MOTS‑c treatment increased the expression of neurotrophic factors.
In plain wordsIn mice with LPS-induced sepsis, MOTS‑c raised nerve growth support factors in the brain.
Peptide
MOTS-c
Outcome
IncreaseNeurotrophic factor expression
Study
mousen: not reported in source
LPS-induced sepsis
Comparator
LPS alone
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
20 mg/kgAs given in this study (mouse).
Source sentences
Summary
MOTS-c treatment increased the survival rate, decreased the MSS score, alleviated brain tissue damage, downregulated the expression of inflammatory factors, reversed the increase in BBB permeability, upregulated the expression of BBB-related proteins and CD31/PDGFRβ, decreased the expression of GFAP…
2 context sentences(design, population, supporting numbers)
Summary · context
The mice were divided into four groups: Control, Control + MOTS-c, LPS, and LPS + MOTS-c groups.
Summary · context
The mice in the latter two groups received MOTS-c (20 mg/kg) four hours before model establishment.
Report a problemFND-4075349409

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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MeSH terms

Keywords

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