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Study · In vitro (cells) · rat · 2018

3 results

MOTS-c improves osteoporosis by promoting osteogenic differentiation of bone marrow mesenchymal stem cells via TGF-β/Smad pathway.

Hu BT, Chen WZ

European review for medical and pharmacological sciences1 Nov 2018Cited by 31 (Europe PMC)

PMID30468456 (opens in a new tab)DOI10.26355/eurrev_201811_16247 (opens in a new tab)PepBankPUB-30468456
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In rat bone marrow mesenchymal stem cells, MOTS‑c remarkably stimulated the formation of calcified nodules.

    In plain wordsIn rat cells, MOTS‑c increased the formation of calcified nodules, a sign of bone-cell development.

    Peptide
    MOTS-c
    Outcome
    IncreaseFormation of calcified nodules
    Study

    ratn: not reported in source

    Bone marrow mesenchymal stem cells
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MOTS-c treatment could remarkably stimulate the formation of calcified nodules in BMSCs.
    1 context sentence
    Summary · context
    Rat BMSCs were isolated and cultured, followed by osteogenic and lipid differentiation.
  2. 02LabIn vitro (cells)Mechanism

    In rat bone marrow mesenchymal stem cells, MOTS‑c significantly upregulated TGF-β/Smad pathway-related genes.

    In plain wordsIn rat cells, MOTS‑c turned up genes of the TGF-β/Smad pathway.

    Peptide
    MOTS-c
    Outcome
    IncreaseTGF-β/Smad pathway-related gene expression
    Study

    ratn: not reported in source

    Bone marrow mesenchymal stem cells
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Besides, TGF-β/Smad pathway-related genes were significantly upregulated after BMSCs were treated with MOTS-c.
    1 context sentence
    Summary · context
    Rat BMSCs were isolated and cultured, followed by osteogenic and lipid differentiation.
  3. 03LabIn vitro (cells)Mechanism

    In rat bone marrow mesenchymal stem cells, the osteogenesis promoted by MOTS‑c was reversed by TGF-β1 knockdown.

    In plain wordsIn rat cells, the bone-forming effect of MOTS‑c disappeared when TGF-β1 was knocked down.

    Peptide
    MOTS-c
    Outcome
    Not applicableOsteogenesis after TGF-β1 knockdown
    Study

    ratn: not reported in source

    Bone marrow mesenchymal stem cells
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Promoted osteogenesis by MOTS-c treatment was reversed by the TGF-β1 knockdown.
    1 context sentence
    Summary · context
    Rat BMSCs were isolated and cultured, followed by osteogenic and lipid differentiation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

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