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Study · In vitro (cells) · 2021

7 results

The mitochondrial-derived peptide MOTS-c promotes homeostasis in aged human placenta-derived mesenchymal stem cells in vitro.

Yu WD, Kim YJ, Cho MJ, Seok J, Kim GJ, Lee CH, Ko JJ, Kim YS, Lee JH

Mitochondrion24 Feb 2021Cited by 17 (Europe PMC)

PMID33639272 (opens in a new tab)DOI10.1016/j.mito.2021.02.010 (opens in a new tab)PepBankPUB-33639272
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In aged human placenta-derived mesenchymal stem cells in vitro, MOTS‑c promoted cell morphology.

    In plain wordsIn lab tests, MOTS‑c promoted the morphology of old stem cells from the human placenta.

    Peptide
    MOTS-c
    Outcome
    Not applicableMorphology of old hPD-MSCs
    Study

    humann: not reported in source

    Aged human placenta-derived mesenchymal stem cells (hPD-MSCs), in vitro
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MOTS-c promoted the morphology of old hPD-MSCs.
    1 context sentence
    Summary · context
    Here, we investigated the restorative effects of MOTS-c on aged human placenta-derived MSCs (hPD-MSCs).
  2. 02LabIn vitro (cells)Mechanism

    In aged hPD-MSCs, MOTS‑c significantly activated AMP-activated protein kinase, its main target pathway.

    In plain wordsIn cells, MOTS‑c switched on AMPK, the main pathway that it acts through.

    Peptide
    MOTS-c
    Outcome
    IncreaseAMPK activation
    Study

    humann: not reported in source

    Aged human placenta-derived mesenchymal stem cells (hPD-MSCs), in vitro
    Outcome group
    Receptor activity and mechanism · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MOTS-c significantly activated AMP-activated protein kinase
    1 context sentence
    Summary · context
    Here, we investigated the restorative effects of MOTS-c on aged human placenta-derived MSCs (hPD-MSCs).
  3. 03LabIn vitro (cells)Mechanism

    In aged hPD-MSCs, MOTS‑c inhibited mTORC1, the antagonistic effector of AMPK.

    In plain wordsIn cells, MOTS‑c reduced the activity of mTORC1, a partner pathway that opposes AMPK.

    Peptide
    MOTS-c
    Outcome
    DecreasemTORC1 activity
    Study

    humann: not reported in source

    Aged human placenta-derived mesenchymal stem cells (hPD-MSCs), in vitro
    Outcome group
    Receptor activity and mechanism · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    inhibited its antagonistic effector mTORC1.
    1 context sentence
    Summary · context
    Here, we investigated the restorative effects of MOTS-c on aged human placenta-derived MSCs (hPD-MSCs).
  4. 04LabIn vitro (cells)Mechanism

    In aged hPD-MSCs, MOTS‑c decreased oxygen consumption.

    In plain wordsIn cells, MOTS‑c lowered oxygen use in old stem cells.

    Peptide
    MOTS-c
    Outcome
    DecreaseOxygen consumption
    Study

    humann: not reported in source

    Aged human placenta-derived mesenchymal stem cells (hPD-MSCs), in vitro
    Outcome group
    Mitochondrial function · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MOTS-c considerably enhanced mitochondrial homeostasis by decreasing oxygen consumption and reactive oxygen species production.
    1 context sentence
    Summary · context
    Here, we investigated the restorative effects of MOTS-c on aged human placenta-derived MSCs (hPD-MSCs).
  5. 05LabIn vitro (cells)Mechanism

    In aged hPD-MSCs, MOTS‑c decreased reactive oxygen species production.

    In plain wordsIn cells, MOTS‑c lowered the production of reactive oxygen species in old stem cells.

    Peptide
    MOTS-c
    Outcome
    DecreaseReactive oxygen species production
    Study

    humann: not reported in source

    Aged human placenta-derived mesenchymal stem cells (hPD-MSCs), in vitro
    Outcome group
    Mitochondrial function · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MOTS-c considerably enhanced mitochondrial homeostasis by decreasing oxygen consumption and reactive oxygen species production.
    1 context sentence
    Summary · context
    Here, we investigated the restorative effects of MOTS-c on aged human placenta-derived MSCs (hPD-MSCs).
  6. 06LabIn vitro (cells)Mechanism

    In aged hPD-MSCs, the mitochondrial state after MOTS‑c treatment was more similar to that of young cells than the state of non-treated old cells.

    In plain wordsIn cells, treated old stem cells had mitochondria more like young cells than non-treated old cells did.

    Peptide
    MOTS-c
    Outcome
    Not applicableMitochondrial state compared with young cells
    Study

    humann: not reported in source

    Aged human placenta-derived mesenchymal stem cells (hPD-MSCs), in vitro
    Comparator
    Non-treated old hPD-MSCs
    Outcome group
    Mitochondrial function · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The mitochondrial state of MOTS-c-treated old hPD-MSCs was more similar to that of young hPD-MSCs than the mitochondrial state of non-treated old hPD-MSCs.
    1 context sentence
    Summary · context
    Here, we investigated the restorative effects of MOTS-c on aged human placenta-derived MSCs (hPD-MSCs).
  7. 07LabIn vitro (cells)Mechanism

    In aged hPD-MSCs, MOTS‑c decreased lipid synthesis.

    In plain wordsIn cells, MOTS‑c lowered the making of fats in old stem cells.

    Peptide
    MOTS-c
    Outcome
    DecreaseLipid synthesis
    Study

    humann: not reported in source

    Aged human placenta-derived mesenchymal stem cells (hPD-MSCs), in vitro
    Outcome group
    Lipids · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MOTS-c also decreased lipid synthesis.
    1 context sentence
    Summary · context
    Here, we investigated the restorative effects of MOTS-c on aged human placenta-derived MSCs (hPD-MSCs).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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