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Study · Animal study (in vivo) · mouse · 2018

7 results

MYOSTATIN MODULATION BY MOTS-C MAY LEAD TO BENEFICIAL EFFECTS IN MUSCLE AND FAT TISSUE

Ligeiro Coelho A, Kim S, Wan J, Oliveira P, Cohen P

Innovation in aging1 Nov 2018

PMCIDPMC6239381 (opens in a new tab)PepBankPUB-98048857
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, MOTS‑c treatment decreased plasma myostatin levels.

    In plain wordsIn mice, MOTS‑c lowered myostatin, a muscle-limiting protein, in the blood.

    Peptide
    MOTS-c
    Outcome
    DecreasePlasma myostatin
    Study

    mousen: not reported in source

    C57/B6 mice
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    5 mg/kg daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The results showed that MOTS-c treatment decreased myostatin levels in plasma and skeletal muscle (p<0.05).
    1 context sentence
    Summary · context
    To further understand the beneficial metabolic effects of MOTS-c, C57/B6 mice were injected daily, IP, with 5 mg/kg of MOTS-c.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, MOTS‑c treatment decreased myostatin levels in skeletal muscle.

    In plain wordsIn mice, MOTS‑c lowered myostatin, a muscle-limiting protein, in skeletal muscle.

    Peptide
    MOTS-c
    Outcome
    DecreaseSkeletal muscle myostatin
    Study

    mousen: not reported in source

    C57/B6 mice
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    5 mg/kg daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The results showed that MOTS-c treatment decreased myostatin levels in plasma and skeletal muscle (p<0.05).
    1 context sentence
    Summary · context
    To further understand the beneficial metabolic effects of MOTS-c, C57/B6 mice were injected daily, IP, with 5 mg/kg of MOTS-c.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, MOTS‑c treatment did not change myostatin in heart muscle.

    In plain wordsIn mice, MOTS‑c did not change myostatin levels in heart muscle.

    Peptide
    MOTS-c
    Outcome
    No significant changeHeart muscle myostatin
    Study

    mousen: not reported in source

    C57/B6 mice
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    5 mg/kg daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    However, no alterations were detected in heart muscle.
    1 context sentence
    Summary · context
    To further understand the beneficial metabolic effects of MOTS-c, C57/B6 mice were injected daily, IP, with 5 mg/kg of MOTS-c.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice, 3 days of MOTS‑c treatment increased the thermogenic marker UCP1 in white adipose tissue.

    In plain wordsIn mice, 3 days of MOTS‑c raised a heat-producing fat marker (UCP1) in white fat.

    Peptide
    MOTS-c
    Outcome
    IncreaseUCP1 in white adipose tissue at 3 days
    Study

    mousen: not reported in source

    C57/B6 mice
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    5 mg/kg daily · intraperitoneal · 3 daysAs given in this study (mouse).

    Source sentences

    Summary
    After 3 days MOTS-c treatment, the thermogenic UCP1, as well as other browning fat markers (Cidea, PGC-1, Era2 and Tbx1) were tendentially or significantly increased in WAT
    1 context sentence
    Summary · context
    To further understand the beneficial metabolic effects of MOTS-c, C57/B6 mice were injected daily, IP, with 5 mg/kg of MOTS-c.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice, 3 days of MOTS‑c treatment tendentially or significantly increased browning markers (Cidea, PGC-1, Era2 and Tbx1) in white adipose tissue.

    In plain wordsIn mice, 3 days of MOTS‑c raised, at least as a trend, several fat-browning markers in white fat.

    Peptide
    MOTS-c
    Outcome
    IncreaseOther browning markers in white adipose tissue at 3 days
    Study

    mousen: not reported in source

    C57/B6 mice
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    5 mg/kg daily · intraperitoneal · 3 daysAs given in this study (mouse).

    Source sentences

    Summary
    After 3 days MOTS-c treatment, the thermogenic UCP1, as well as other browning fat markers (Cidea, PGC-1, Era2 and Tbx1) were tendentially or significantly increased in WAT
    1 context sentence
    Summary · context
    To further understand the beneficial metabolic effects of MOTS-c, C57/B6 mice were injected daily, IP, with 5 mg/kg of MOTS-c.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice, the effect on browning markers was reversed after 8 weeks of MOTS‑c injection.

    In plain wordsIn mice, the rise in fat-browning markers seen early on was reversed after 8 weeks of MOTS‑c.

    Peptide
    MOTS-c
    Outcome
    MixedBrowning markers in white adipose tissue at 8 weeks
    Study

    mousen: not reported in source

    C57/B6 mice
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    5 mg/kg daily · intraperitoneal · 8 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The effect on markers were reversed after 8 weeks of injection
    1 context sentence
    Summary · context
    To further understand the beneficial metabolic effects of MOTS-c, C57/B6 mice were injected daily, IP, with 5 mg/kg of MOTS-c.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice, UCP1 transcripts in white adipose tissue increased further after 8 weeks of MOTS‑c injection.

    In plain wordsIn mice, the heat-producing marker UCP1 rose even more in white fat after 8 weeks of MOTS‑c.

    Peptide
    MOTS-c
    Outcome
    IncreaseUCP1 transcripts at 8 weeks
    Study

    mousen: not reported in source

    C57/B6 mice
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    5 mg/kg daily · intraperitoneal · 8 weeksAs given in this study (mouse).

    Source sentences

    Summary
    nevertheless UCP1 transcripts were increased further (p<0.05).
    1 context sentence
    Summary · context
    To further understand the beneficial metabolic effects of MOTS-c, C57/B6 mice were injected daily, IP, with 5 mg/kg of MOTS-c.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

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