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Study · Animal study (in vivo) · mouse · 2018

3 results

STRESS RESISTANCE AND THE INTEGRATED MITONUCLEAR GENOMES

Lee C

Innovation in aging1 Nov 2018

PMCIDPMC6226847 (opens in a new tab)PepBankPUB-95763102
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, MOTS‑c treatment reversed age-dependent insulin resistance.

    In plain wordsIn mice, MOTS‑c treatment reversed insulin resistance that came with age.

    Peptide
    MOTS-c
    Outcome
    DecreaseAge-dependent insulin resistance
    Study

    mousen: not reported in source

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Further, MOTS-c treatment reversed age-dependent insulin resistance.
  2. 02LabIn vitro (cells)Mechanism

    In cells, MOTS‑c rapidly and dynamically translocated to the nucleus to regulate the nuclear genome in response to cellular stress.

    In plain wordsIn cells under stress, MOTS‑c moved quickly into the nucleus and regulated gene activity.

    Peptide
    MOTS-c
    Outcome
    Not applicableNuclear translocation under cellular stress
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our recent studies show that MOTS-c rapidly and dynamically translocates to the nucleus to regulate the nuclear genome in response to cellular stress.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In mice, MOTS‑c expression depends on age and tissue.

    In plain wordsIn mice, the body's own MOTS‑c level differs with age and between tissues.

    Peptide
    MOTS-c
    Outcome
    MixedMOTS-c expression by age and tissue
    Study

    mousen: not reported in source

    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    In mice, MOTS-c expression is age- and tissue-dependent.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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