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Study · In vitro (cells) · 2020

8 results

Effects of MOTS-c on the mitochondrial function of cells harboring 3243 A to G mutant mitochondrial DNA.

Ahn CH, Choi EH, Kong BS, Cho YM

Molecular biology reports11 Apr 2020Cited by 6 (Europe PMC)

PMID32279209 (opens in a new tab)DOI10.1007/s11033-020-05429-z (opens in a new tab)PepBankPUB-32279209
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In mutant cybrid cells, synthetic MOTS‑c did not significantly change ATP content.

    In plain wordsIn cells with a mitochondrial mutation, added MOTS‑c did not change ATP content.

    Peptide
    MOTS-c
    Outcome
    No significant changeATP content after exogenous MOTS-c
    Study

    n: not reported in source

    cybrid cells harboring 3243 A to G mutant mtDNA
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exogenous (synthetic) MOTS-c did not show a significant effect on the ATP content or the mRNA and protein levels of the mitochondrial complex in the mutant cybrid cells.
    1 context sentence
    Summary · context
    We investigated the effect of exogenous and endogenous MOTS-c on mitochondrial function in a cybrid cell harboring 3243 A to G mutant mtDNA, which causes significant mitochondrial dysfunction.
  2. 02LabIn vitro (cells)Efficacy outcome

    In mutant cybrid cells, synthetic MOTS‑c did not significantly change mRNA levels of the mitochondrial complex.

    In plain wordsIn cells with a mitochondrial mutation, added MOTS‑c did not change mitochondrial complex mRNA levels.

    Peptide
    MOTS-c
    Outcome
    No significant changeMitochondrial complex mRNA levels after exogenous MOTS-c
    Study

    n: not reported in source

    cybrid cells harboring 3243 A to G mutant mtDNA
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exogenous (synthetic) MOTS-c did not show a significant effect on the ATP content or the mRNA and protein levels of the mitochondrial complex in the mutant cybrid cells.
    1 context sentence
    Summary · context
    We investigated the effect of exogenous and endogenous MOTS-c on mitochondrial function in a cybrid cell harboring 3243 A to G mutant mtDNA, which causes significant mitochondrial dysfunction.
  3. 03LabIn vitro (cells)Efficacy outcome

    In mutant cybrid cells, synthetic MOTS‑c did not significantly change protein levels of the mitochondrial complex.

    In plain wordsIn cells with a mitochondrial mutation, added MOTS‑c did not change mitochondrial complex protein levels.

    Peptide
    MOTS-c
    Outcome
    No significant changeMitochondrial complex protein levels after exogenous MOTS-c
    Study

    n: not reported in source

    cybrid cells harboring 3243 A to G mutant mtDNA
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exogenous (synthetic) MOTS-c did not show a significant effect on the ATP content or the mRNA and protein levels of the mitochondrial complex in the mutant cybrid cells.
    1 context sentence
    Summary · context
    We investigated the effect of exogenous and endogenous MOTS-c on mitochondrial function in a cybrid cell harboring 3243 A to G mutant mtDNA, which causes significant mitochondrial dysfunction.
  4. 04LabIn vitro (cells)Efficacy outcome

    In mutant cybrid cells, synthetic MOTS‑c did not affect basal mitochondrial respiration.

    In plain wordsIn cells with a mitochondrial mutation, added MOTS‑c did not change resting mitochondrial respiration.

    Peptide
    MOTS-c
    Outcome
    No significant changeBasal mitochondrial respiration after exogenous MOTS-c
    Study

    n: not reported in source

    cybrid cells harboring 3243 A to G mutant mtDNA
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Basal and stimulated mitochondrial respiration were also not affected by exogenous MOTS-c.
    1 context sentence
    Summary · context
    We investigated the effect of exogenous and endogenous MOTS-c on mitochondrial function in a cybrid cell harboring 3243 A to G mutant mtDNA, which causes significant mitochondrial dysfunction.
  5. 05LabIn vitro (cells)Efficacy outcome

    In mutant cybrid cells, synthetic MOTS‑c did not affect stimulated mitochondrial respiration.

    In plain wordsIn cells with a mitochondrial mutation, added MOTS‑c did not change stimulated mitochondrial respiration.

    Peptide
    MOTS-c
    Outcome
    No significant changeStimulated mitochondrial respiration after exogenous MOTS-c
    Study

    n: not reported in source

    cybrid cells harboring 3243 A to G mutant mtDNA
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Basal and stimulated mitochondrial respiration were also not affected by exogenous MOTS-c.
    1 context sentence
    Summary · context
    We investigated the effect of exogenous and endogenous MOTS-c on mitochondrial function in a cybrid cell harboring 3243 A to G mutant mtDNA, which causes significant mitochondrial dysfunction.

Studies that did not test the peptide alone3

In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MOTS-c.

  1. 06LabNot a test of MOTS-c aloneIn vitro (cells)Efficacy outcome

    In mutant cybrid cells stably expressing MOTS‑c from an expression vector, ATP production was not affected.

    In plain wordsIn cells with a mitochondrial mutation that made their own MOTS‑c from added DNA, ATP production did not change.

    Peptide
    MOTS-c
    Outcome
    No significant changeATP production with MOTS-c expression vector
    Study

    n: not reported in source

    cybrid cells harboring 3243 A to G mutant mtDNA
    Outcome group
    Mitochondrial function · Metabolic and weight

    Source sentences

    Summary
    The mutant cybrid cells transfected with the MOTS-c EGFP expression vector stably expressed MOTS-c, but ATP production and mRNA and protein levels of the mitochondrial complex were not affected.
    1 context sentence
    Summary · context
    We investigated the effect of exogenous and endogenous MOTS-c on mitochondrial function in a cybrid cell harboring 3243 A to G mutant mtDNA, which causes significant mitochondrial dysfunction.

    In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MOTS-c.

  2. 07LabNot a test of MOTS-c aloneIn vitro (cells)Efficacy outcome

    In mutant cybrid cells stably expressing MOTS‑c from an expression vector, mRNA levels of the mitochondrial complex were not affected.

    In plain wordsIn cells with a mitochondrial mutation that made their own MOTS‑c from added DNA, mitochondrial complex mRNA did not change.

    Peptide
    MOTS-c
    Outcome
    No significant changeMitochondrial complex mRNA levels with MOTS-c expression vector
    Study

    n: not reported in source

    cybrid cells harboring 3243 A to G mutant mtDNA
    Outcome group
    Mitochondrial function · Metabolic and weight

    Source sentences

    Summary
    The mutant cybrid cells transfected with the MOTS-c EGFP expression vector stably expressed MOTS-c, but ATP production and mRNA and protein levels of the mitochondrial complex were not affected.
    1 context sentence
    Summary · context
    We investigated the effect of exogenous and endogenous MOTS-c on mitochondrial function in a cybrid cell harboring 3243 A to G mutant mtDNA, which causes significant mitochondrial dysfunction.

    In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MOTS-c.

  3. 08LabNot a test of MOTS-c aloneIn vitro (cells)Efficacy outcome

    In mutant cybrid cells stably expressing MOTS‑c from an expression vector, protein levels of the mitochondrial complex were not affected.

    In plain wordsIn cells with a mitochondrial mutation that made their own MOTS‑c from added DNA, mitochondrial complex protein did not change.

    Peptide
    MOTS-c
    Outcome
    No significant changeMitochondrial complex protein levels with MOTS-c expression vector
    Study

    n: not reported in source

    cybrid cells harboring 3243 A to G mutant mtDNA
    Outcome group
    Mitochondrial function · Metabolic and weight

    Source sentences

    Summary
    The mutant cybrid cells transfected with the MOTS-c EGFP expression vector stably expressed MOTS-c, but ATP production and mRNA and protein levels of the mitochondrial complex were not affected.
    1 context sentence
    Summary · context
    We investigated the effect of exogenous and endogenous MOTS-c on mitochondrial function in a cybrid cell harboring 3243 A to G mutant mtDNA, which causes significant mitochondrial dysfunction.

    In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MOTS-c.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 18Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 15 times, first on 13 Oct 2026, 21:44 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    10 Oct 2026, 08:19 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

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