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Study · In vitro (cells) · 2025

10 results

MOTS-c Impact on Muscle Cell Differentiation and Metabolism Across Fiber Types.

Leciejewska N, Pruszyńska-Oszmałek E, Kołodziejski P, Szczepankiewicz D, Nogowski L, Sassek M

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology1 Jan 2025Cited by 2 (Europe PMC)

PMID39876762 (opens in a new tab)DOI10.33594/000000755 (opens in a new tab)PepBankPUB-39876762
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In C2C12 muscle cells, MOTS‑c at 10 and 100 nM increased cell survival.

    In plain wordsIn cells, MOTS‑c increased the survival of C2C12 muscle cells.

    Peptide
    MOTS-c
    Outcome
    IncreaseSurvival of C2C12 cells
    Study

    n: not reported in source

    C2C12 cells
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    10 and 100 nMAs given in this study.

    Source sentences

    Summary
    Notably, our investigations revealed that MOTS-c increased the survival of C2C12 cells at doses of 10 and 100 nM (p<0.01)
    1 context sentence
    Summary · context
    We conducted a study to explore the effect of MOTS-c on cellular processes using the C2C12 and L6 cell lines, representing different metabolic types of muscle fibers.
  2. 02LabIn vitro (cells)Mechanism

    In C2C12 muscle cells, MOTS‑c stimulated phosphorylation of extracellular signal-regulated kinase within 5 min of incubation.

    In plain wordsIn cells, MOTS‑c switched on the ERK signalling protein in C2C12 muscle cells within 5 minutes.

    Peptide
    MOTS-c
    Outcome
    IncreaseERK phosphorylation in C2C12 cells
    Study

    n: not reported in source

    C2C12 cells
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated · 5 minAs given in this study.

    Source sentences

    Summary
    stimulated the phosphorylation of extracellular signal-regulated kinase within 5 min of incubation (p<0.05)
    1 context sentence
    Summary · context
    We conducted a study to explore the effect of MOTS-c on cellular processes using the C2C12 and L6 cell lines, representing different metabolic types of muscle fibers.
  3. 03LabIn vitro (cells)Efficacy outcome

    In L6 muscle cells, MOTS‑c did not increase cell survival.

    In plain wordsIn cells, MOTS‑c did not increase the survival of L6 muscle cells.

    Peptide
    MOTS-c
    Outcome
    No significant changeSurvival of L6 cells
    Study

    n: not reported in source

    L6 cells
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Remarkably, these effects were not observed in L6 cells
    1 context sentence
    Summary · context
    We conducted a study to explore the effect of MOTS-c on cellular processes using the C2C12 and L6 cell lines, representing different metabolic types of muscle fibers.
  4. 04LabIn vitro (cells)Mechanism

    In L6 muscle cells, MOTS‑c did not stimulate phosphorylation of extracellular signal-regulated kinase.

    In plain wordsIn cells, MOTS‑c did not switch on the ERK signalling protein in L6 muscle cells.

    Peptide
    MOTS-c
    Outcome
    No significant changeERK phosphorylation in L6 cells
    Study

    n: not reported in source

    L6 cells
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Remarkably, these effects were not observed in L6 cells
    1 context sentence
    Summary · context
    We conducted a study to explore the effect of MOTS-c on cellular processes using the C2C12 and L6 cell lines, representing different metabolic types of muscle fibers.
  5. 05LabIn vitro (cells)Efficacy outcome

    In C2C12 muscle cells, MOTS‑c reduced the rate of proliferation.

    In plain wordsIn cells, MOTS‑c slowed the growth rate of C2C12 muscle cells.

    Peptide
    MOTS-c
    Outcome
    DecreaseProliferation of C2C12 cells
    Study

    n: not reported in source

    C2C12 cells
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    both cell lines showed a reduced rate of proliferation.
    1 context sentence
    Summary · context
    We conducted a study to explore the effect of MOTS-c on cellular processes using the C2C12 and L6 cell lines, representing different metabolic types of muscle fibers.
  6. 06LabIn vitro (cells)Efficacy outcome

    In L6 muscle cells, MOTS‑c reduced the rate of proliferation.

    In plain wordsIn cells, MOTS‑c slowed the growth rate of L6 muscle cells.

    Peptide
    MOTS-c
    Outcome
    DecreaseProliferation of L6 cells
    Study

    n: not reported in source

    L6 cells
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    both cell lines showed a reduced rate of proliferation.
    1 context sentence
    Summary · context
    We conducted a study to explore the effect of MOTS-c on cellular processes using the C2C12 and L6 cell lines, representing different metabolic types of muscle fibers.
  7. 07LabIn vitro (cells)Efficacy outcome

    In C2C12 muscle cells, MOTS‑c promoted differentiation by increasing expression of muscle regulatory factors.

    In plain wordsIn cells, MOTS‑c pushed C2C12 muscle cells to mature by raising muscle regulatory factor expression.

    Peptide
    MOTS-c
    Outcome
    IncreaseDifferentiation of C2C12 cells (muscle regulatory factors)
    Study

    n: not reported in source

    C2C12 cells
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, MOTS-c promotes the differentiation of C2C12 cells by increasing the expression of muscle regulatory factors
    1 context sentence
    Summary · context
    We conducted a study to explore the effect of MOTS-c on cellular processes using the C2C12 and L6 cell lines, representing different metabolic types of muscle fibers.
  8. 08LabIn vitro (cells)Efficacy outcome

    In L6 muscle cells, MOTS‑c did not promote differentiation.

    In plain wordsIn cells, MOTS‑c did not push L6 muscle cells to mature.

    Peptide
    MOTS-c
    Outcome
    No significant changeDifferentiation of L6 cells (muscle regulatory factors)
    Study

    n: not reported in source

    L6 cells
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but it does not produce such an effect in L6 cells.
    1 context sentence
    Summary · context
    We conducted a study to explore the effect of MOTS-c on cellular processes using the C2C12 and L6 cell lines, representing different metabolic types of muscle fibers.
  9. 09LabIn vitro (cells)Efficacy outcome

    In L6 muscle cells treated with free fatty acids, MOTS‑c increased lipid accumulation.

    In plain wordsIn cells, MOTS‑c raised fat build-up in L6 muscle cells exposed to free fatty acids.

    Peptide
    MOTS-c
    Outcome
    IncreaseLipid accumulation in L6 cells with free fatty acids
    Study

    n: not reported in source

    L6 cells
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, cells were treated with physiological concentrations of free fatty acids and MOTS-c, unveiling an augmentation in lipid accumulation observed in L6 cells and a decrease in lipid accumulation in C2C12 cells.
    1 context sentence
    Summary · context
    We conducted a study to explore the effect of MOTS-c on cellular processes using the C2C12 and L6 cell lines, representing different metabolic types of muscle fibers.
  10. 10LabIn vitro (cells)Efficacy outcome

    In C2C12 muscle cells treated with free fatty acids, MOTS‑c decreased lipid accumulation.

    In plain wordsIn cells, MOTS‑c lowered fat build-up in C2C12 muscle cells exposed to free fatty acids.

    Peptide
    MOTS-c
    Outcome
    DecreaseLipid accumulation in C2C12 cells with free fatty acids
    Study

    n: not reported in source

    C2C12 cells
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, cells were treated with physiological concentrations of free fatty acids and MOTS-c, unveiling an augmentation in lipid accumulation observed in L6 cells and a decrease in lipid accumulation in C2C12 cells.
    1 context sentence
    Summary · context
    We conducted a study to explore the effect of MOTS-c on cellular processes using the C2C12 and L6 cell lines, representing different metabolic types of muscle fibers.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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