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Study · Animal study (in vivo) · 2026

8 results

MOTS-c, a mitochondrial-derived peptide, ameliorates lysosomal membrane permeability and improves survival of soft tissue transplantation.

Shi J, Wu Y, Liu X, Xia W, Wu J, Lou J, Zhang X, Zhang J, Yang N, Chi W, Xiang L, Zhang Y and 7 more

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Shu Y, Miao R, Zhao J, Zhu X, Qi J, Xiao J, Zhou K

Autophagy2 Jun 2026

PMID42153537 (opens in a new tab)DOI10.1080/15548627.2026.2677180 (opens in a new tab)PepBankPUB-42153537
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ischemic flaps, MOTS‑c treatment improved blood flow perfusion.

    In plain wordsIn animals with a poorly supplied skin flap, MOTS‑c treatment improved blood flow.

    Peptide
    MOTS-c
    Outcome
    IncreaseBlood flow perfusion in ischemic flaps
    Study

    n: not reported in source

    Ischemic flap
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tissue clearing, laser speckle contrast imaging and Doppler analyses revealed improved blood flow perfusion following MOTS-c treatment.
    1 context sentence
    Summary · context
    This study investigated the protective effects and underlying mechanisms of MOTS-c in ischemic flaps.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ischemic flaps, MOTS‑c treatment was followed by enhanced angiogenesis.

    In plain wordsIn animals with a poorly supplied skin flap, MOTS‑c treatment was followed by more new blood vessels.

    Peptide
    MOTS-c
    Outcome
    IncreaseAngiogenesis in ischemic flaps
    Study

    n: not reported in source

    Ischemic flap
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    demonstrated enhanced angiogenesis and collagen remodeling
    2 context sentences
    Summary · context
    Tissue clearing, laser speckle contrast imaging and Doppler analyses revealed improved blood flow perfusion following MOTS-c treatment.
    Summary · context
    This study investigated the protective effects and underlying mechanisms of MOTS-c in ischemic flaps.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ischemic flaps, MOTS‑c treatment was followed by enhanced collagen remodeling.

    In plain wordsIn animals with a poorly supplied skin flap, MOTS‑c treatment was followed by more tissue remodeling.

    Peptide
    MOTS-c
    Outcome
    IncreaseCollagen remodeling in ischemic flaps
    Study

    n: not reported in source

    Ischemic flap
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    demonstrated enhanced angiogenesis and collagen remodeling
    2 context sentences
    Summary · context
    Tissue clearing, laser speckle contrast imaging and Doppler analyses revealed improved blood flow perfusion following MOTS-c treatment.
    Summary · context
    This study investigated the protective effects and underlying mechanisms of MOTS-c in ischemic flaps.
  4. 04AnimalAnimal study (in vivo)Mechanism

    MOTS‑c reduced endothelial pyroptosis in ischemic flaps.

    In plain wordsIn animals with a poorly supplied skin flap, MOTS‑c reduced a form of inflammatory cell death in vessel cells.

    Peptide
    MOTS-c
    Outcome
    DecreaseEndothelial pyroptosis
    Study

    n: not reported in source

    Ischemic flap
    Outcome group
    Cell viability and death · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MOTS-c reduced endothelial pyroptosis, enhanced autophagy, and attenuated LMP in ischemic flaps.
    1 context sentence
    Summary · context
    This study investigated the protective effects and underlying mechanisms of MOTS-c in ischemic flaps.
  5. 05AnimalAnimal study (in vivo)Mechanism

    MOTS‑c enhanced autophagy in ischemic flaps.

    In plain wordsIn animals with a poorly supplied skin flap, MOTS‑c increased the cells' self-cleaning process (autophagy).

    Peptide
    MOTS-c
    Outcome
    IncreaseAutophagy
    Study

    n: not reported in source

    Ischemic flap
    Outcome group
    Cell viability and death · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MOTS-c reduced endothelial pyroptosis, enhanced autophagy, and attenuated LMP in ischemic flaps.
    1 context sentence
    Summary · context
    This study investigated the protective effects and underlying mechanisms of MOTS-c in ischemic flaps.
  6. 06AnimalAnimal study (in vivo)Mechanism

    MOTS‑c attenuated lysosomal membrane permeability in ischemic flaps.

    In plain wordsIn animals with a poorly supplied skin flap, MOTS‑c reduced leakage of the cells' lysosomes.

    Peptide
    MOTS-c
    Outcome
    DecreaseLysosomal membrane permeabilization
    Study

    n: not reported in source

    Ischemic flap
    Outcome group
    Cell viability and death · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MOTS-c reduced endothelial pyroptosis, enhanced autophagy, and attenuated LMP in ischemic flaps.
    1 context sentence
    Summary · context
    This study investigated the protective effects and underlying mechanisms of MOTS-c in ischemic flaps.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In ischemic flaps, MOTS‑c suppressed PLA2G4A phosphorylation, which enhanced autophagy and reduced pyroptosis and LMP.

    In plain wordsIn animals with a poorly supplied skin flap, MOTS‑c acted by lowering activity of the enzyme PLA2G4A.

    Peptide
    MOTS-c
    Outcome
    DecreasePLA2G4A phosphorylation
    Study

    n: not reported in source

    Ischemic flap
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, in vivo overexpression of PLA2G4A/cPLA2 (phospholipase A2, group IVA (calcium, calcium dependent)) via AAV confirmed that MOTS-c enhances autophagy and reduces pyroptosis and LMP by suppressing PLA2G4A phosphorylation.
    1 context sentence
    Summary · context
    This study investigated the protective effects and underlying mechanisms of MOTS-c in ischemic flaps.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In ischemic flaps, MOTS‑c inhibited PLA2G4A via the MAPK1-MAPK3-NFKB cascade, reducing LMP and enhancing flap survival.

    In plain wordsIn animals with a poorly supplied skin flap, MOTS‑c improved flap survival.

    Peptide
    MOTS-c
    Outcome
    IncreaseFlap survival
    Study

    n: not reported in source

    Ischemic flap
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, MOTS-c inhibited PLA2G4A via the MAPK1-MAPK3-NFKB signaling cascade, thereby reducing LMP and enhancing flap survival.
    1 context sentence
    Summary · context
    This study investigated the protective effects and underlying mechanisms of MOTS-c in ischemic flaps.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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