MOTS-c interacts synergistically with exercise intervention to regulate PGC-1α expression, attenuate insulin resistance and enhance glucose metabolism in mice via AMPK signaling pathway.

Yang B, Yu Q, Chang B, Guo Q, Xu S, Yi X, Cao S

Biochimica et biophysica acta. Molecular basis of disease13 Mar 2021Cited by 71 (Europe PMC)

PMID33722744DOI10.1016/j.bbadis.2021.166126PepBankPUB-33722744

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

1 result from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In C2C12 myotubes, recombinant MOTS‑c supplementation upregulated the protein and mRNA expression of MOTS‑c.
In plain wordsIn cells, adding MOTS‑c increased MOTS‑c levels in the cells.
Peptide
MOTS-c
Outcome
IncreaseMOTS-c expression after recombinant MOTS-c supplementation
Study
n: not reported in source
C2C12 myotubes
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
PGC-1α knockdown downregulated the protein and mRNA expressions of MOTS-c in C2C12 myotubes, whereas both PGC-1α overexpression and recombinant MOTS-c supplementation upregulated the protein and mRNA expressions of MOTS-c in C2C12 myotubes.
Report a problemFND-3372274404

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

02AnimalEndogenous levelAnimal study (in vivo)Other
In high-fat diet-induced obese mice, skeletal muscle levels of the body's own MOTS‑c were markedly reduced.
In plain wordsIn obese mice fed a high-fat diet, the body's own MOTS‑c in muscle was much lower.
Peptide
MOTS-c
Outcome
DecreaseSkeletal muscle MOTS-c level in obese mice
Study
mousen: not reported in source
High-fat diet-induced obese mice
Outcome group
Mitochondrial function · Metabolic and weight
Source sentences
Summary
Furthermore, the skeletal muscle and plasma levels of MOTS-c were markedly reduced in high-fat diet-induced obese mice.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3372274405
03AnimalEndogenous levelAnimal study (in vivo)Other
In high-fat diet-induced obese mice, plasma levels of the body's own MOTS‑c were markedly reduced.
In plain wordsIn obese mice fed a high-fat diet, the body's own MOTS‑c in blood was much lower.
Peptide
MOTS-c
Outcome
DecreasePlasma MOTS-c level in obese mice
Study
mousen: not reported in source
High-fat diet-induced obese mice
Outcome group
Mitochondrial function · Metabolic and weight
Source sentences
Summary
Furthermore, the skeletal muscle and plasma levels of MOTS-c were markedly reduced in high-fat diet-induced obese mice.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3372274406
04AnimalEndogenous levelAnimal study (in vivo)Other
In mice, treadmill training upregulated the protein level of the body's own MOTS‑c in skeletal muscle.
In plain wordsIn mice, treadmill training raised the body's own MOTS‑c protein in muscle.
Peptide
MOTS-c
Outcome
IncreaseSkeletal muscle MOTS-c protein after treadmill training
Study
mousen: not reported in source
Outcome group
Exercise and physical function · Metabolic and weight
Source sentences
Summary
Treadmill training remarkably upregulated the protein levels of MOTS-c, PGC-1α and GLUT4, along with the phosphorylation levels of AMPK and ACC.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3372274407
05LabEndogenous levelIn vitro (cells)Mechanism
In C2C12 myotubes, the AMPK inhibitor Compound C decreased the protein and mRNA expression of the body's own MOTS‑c.
In plain wordsIn cells, blocking AMPK lowered the cells' own MOTS‑c production.
Peptide
MOTS-c
Outcome
DecreaseMOTS-c expression after AMPK inhibition
Study
n: not reported in source
C2C12 myotubes
Outcome group
Receptor activity and mechanism · Metabolic and weight
Source sentences
Summary
It was found that C2C12 myotubes exposed to Compound C (an AMPK inhibitor) had deceases in the protein and mRNA expressions of PGC-1α and MOTS-c.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3372274401
06LabEndogenous levelIn vitro (cells)Mechanism
In C2C12 myotubes, PGC-1α knockdown downregulated the protein and mRNA expression of the body's own MOTS‑c.
In plain wordsIn cells, removing PGC-1α lowered the cells' own MOTS‑c production.
Peptide
MOTS-c
Outcome
DecreaseMOTS-c expression after PGC-1α knockdown
Study
n: not reported in source
C2C12 myotubes
Outcome group
Receptor activity and mechanism · Metabolic and weight
Source sentences
Summary
PGC-1α knockdown downregulated the protein and mRNA expressions of MOTS-c in C2C12 myotubes, whereas both PGC-1α overexpression and recombinant MOTS-c supplementation upregulated the protein and mRNA expressions of MOTS-c in C2C12 myotubes.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3372274402
07LabEndogenous levelIn vitro (cells)Mechanism
In C2C12 myotubes, PGC-1α overexpression upregulated the protein and mRNA expression of the body's own MOTS‑c.
In plain wordsIn cells, raising PGC-1α increased the cells' own MOTS‑c production.
Peptide
MOTS-c
Outcome
IncreaseMOTS-c expression after PGC-1α overexpression
Study
n: not reported in source
C2C12 myotubes
Outcome group
Receptor activity and mechanism · Metabolic and weight
Source sentences
Summary
PGC-1α knockdown downregulated the protein and mRNA expressions of MOTS-c in C2C12 myotubes, whereas both PGC-1α overexpression and recombinant MOTS-c supplementation upregulated the protein and mRNA expressions of MOTS-c in C2C12 myotubes.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3372274403

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 12:50 UTC
Study data updated · source update from Europe PMC
Version 2
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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