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Study · Animal study (in vivo) · mouse · 2024

7 results

Central and peripheral mechanism of MOTS-c attenuates pain hypersensitivity in a mice model of inflammatory pain.

Wang Z, Yang L, Xu L, Liao J, Lu P, Jiang J

Neurological research1 Jan 2024Cited by 6 (Europe PMC)

PMID37899006 (opens in a new tab)DOI10.1080/01616412.2023.2258584 (opens in a new tab)PepBankPUB-37899006
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with formalin-induced acute inflammatory pain, MOTS‑c treatment produced anti-allodynic effects.

    In plain wordsIn mice, MOTS‑c reduced pain sensitivity in a formalin-induced acute inflammatory pain model.

    Peptide
    MOTS-c
    Outcome
    DecreaseAllodynia in formalin-induced acute inflammatory pain
    Study

    mousen: not reported in source

    Formalin, capsaicin, λ-Carrageenan and CFA inflammatory pain models
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results showed that MOTS-c treatment produced potent anti-allodynic effects in formalin-induced acute inflammatory pain, capsaicin-induced nocifensive behaviors and λ-Carrageenan/CFA-induced chronic inflammatory pain model.
    1 context sentence
    Summary · context
    Male Kunming mice (8-10 weeks-old) were intraplantar injected with formalin, capsaicin, λ-Carrageenan and complete Freund adjuvant (CFA) to establish acute and chronic inflammatory pain.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, MOTS‑c treatment reduced capsaicin-induced nocifensive behaviors.

    In plain wordsIn mice, MOTS‑c reduced pain-related behaviors caused by capsaicin.

    Peptide
    MOTS-c
    Outcome
    DecreaseCapsaicin-induced nocifensive behaviors
    Study

    mousen: not reported in source

    Formalin, capsaicin, λ-Carrageenan and CFA inflammatory pain models
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results showed that MOTS-c treatment produced potent anti-allodynic effects in formalin-induced acute inflammatory pain, capsaicin-induced nocifensive behaviors and λ-Carrageenan/CFA-induced chronic inflammatory pain model.
    1 context sentence
    Summary · context
    Male Kunming mice (8-10 weeks-old) were intraplantar injected with formalin, capsaicin, λ-Carrageenan and complete Freund adjuvant (CFA) to establish acute and chronic inflammatory pain.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with λ-Carrageenan/CFA-induced chronic inflammatory pain, MOTS‑c treatment produced anti-allodynic effects.

    In plain wordsIn mice, MOTS‑c reduced pain sensitivity in a long-lasting inflammatory pain model.

    Peptide
    MOTS-c
    Outcome
    DecreaseAllodynia in λ-Carrageenan/CFA-induced chronic inflammatory pain
    Study

    mousen: not reported in source

    Formalin, capsaicin, λ-Carrageenan and CFA inflammatory pain models
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results showed that MOTS-c treatment produced potent anti-allodynic effects in formalin-induced acute inflammatory pain, capsaicin-induced nocifensive behaviors and λ-Carrageenan/CFA-induced chronic inflammatory pain model.
    1 context sentence
    Summary · context
    Male Kunming mice (8-10 weeks-old) were intraplantar injected with formalin, capsaicin, λ-Carrageenan and complete Freund adjuvant (CFA) to establish acute and chronic inflammatory pain.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In CFA-injected mice, central MOTS‑c treatment significantly ameliorated the release of inflammatory factors in the spinal dorsal horn.

    In plain wordsIn mice, MOTS‑c given centrally reduced the release of inflammatory factors in the spinal cord after CFA injection.

    Peptide
    MOTS-c
    Outcome
    DecreaseCFA-evoked release of inflammatory factors in the spinal dorsal horn
    Study

    mousen: not reported in source

    Formalin, capsaicin, λ-Carrageenan and CFA inflammatory pain models
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated · centralAs given in this study (mouse).

    Source sentences

    Summary
    Further mechanistic studies revealed that central MOTS-c treatment significantly ameliorated CFA-evoked the release of inflammatory factors and activation of glial cells and neurons in the spinal dorsal horn.
    1 context sentence
    Summary · context
    Male Kunming mice (8-10 weeks-old) were intraplantar injected with formalin, capsaicin, λ-Carrageenan and complete Freund adjuvant (CFA) to establish acute and chronic inflammatory pain.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In CFA-injected mice, central MOTS‑c treatment significantly ameliorated activation of glial cells and neurons in the spinal dorsal horn.

    In plain wordsIn mice, MOTS‑c given centrally reduced activation of spinal cord glial cells and neurons after CFA injection.

    Peptide
    MOTS-c
    Outcome
    DecreaseCFA-evoked activation of glial cells and neurons in the spinal dorsal horn
    Study

    mousen: not reported in source

    Formalin, capsaicin, λ-Carrageenan and CFA inflammatory pain models
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated · centralAs given in this study (mouse).

    Source sentences

    Summary
    Further mechanistic studies revealed that central MOTS-c treatment significantly ameliorated CFA-evoked the release of inflammatory factors and activation of glial cells and neurons in the spinal dorsal horn.
    1 context sentence
    Summary · context
    Male Kunming mice (8-10 weeks-old) were intraplantar injected with formalin, capsaicin, λ-Carrageenan and complete Freund adjuvant (CFA) to establish acute and chronic inflammatory pain.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In CFA-injected mice, peripheral MOTS‑c treatment reduced inflammatory responses in the surface structure of the hindpaw skin.

    In plain wordsIn mice, MOTS‑c given peripherally reduced inflammation in the hindpaw skin after CFA injection.

    Peptide
    MOTS-c
    Outcome
    DecreaseCFA-evoked inflammatory responses in hindpaw skin
    Study

    mousen: not reported in source

    Formalin, capsaicin, λ-Carrageenan and CFA inflammatory pain models
    Outcome group
    Inflammation markers · Skin and wound
    Studied dose
    Dose not stated · peripheralAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, peripheral MOTS-c treatment reduced CFA-evoked inflammatory responses in the surface structure of hindpaw skin, accompanied by inhibiting excitation of peripheral calcitonin gene-related peptide (CGRP) and P2X3 nociceptive neurons.
    1 context sentence
    Summary · context
    Male Kunming mice (8-10 weeks-old) were intraplantar injected with formalin, capsaicin, λ-Carrageenan and complete Freund adjuvant (CFA) to establish acute and chronic inflammatory pain.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In CFA-injected mice, peripheral MOTS‑c treatment inhibited excitation of peripheral CGRP and P2X3 nociceptive neurons.

    In plain wordsIn mice, MOTS‑c given peripherally dampened the activity of pain-sensing nerve cells after CFA injection.

    Peptide
    MOTS-c
    Outcome
    DecreaseExcitation of peripheral CGRP and P2X3 nociceptive neurons
    Study

    mousen: not reported in source

    Formalin, capsaicin, λ-Carrageenan and CFA inflammatory pain models
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · peripheralAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, peripheral MOTS-c treatment reduced CFA-evoked inflammatory responses in the surface structure of hindpaw skin, accompanied by inhibiting excitation of peripheral calcitonin gene-related peptide (CGRP) and P2X3 nociceptive neurons.
    1 context sentence
    Summary · context
    Male Kunming mice (8-10 weeks-old) were intraplantar injected with formalin, capsaicin, λ-Carrageenan and complete Freund adjuvant (CFA) to establish acute and chronic inflammatory pain.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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