Melanotan I (afamelanotide) studies: 218 papers with results
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- Desensitization of melanotropin receptors in COS-7 cells.
Polgar WE · Life sciences · 1996
In vitro (cells) · 4 results
- Melanocortin-receptor 4 activation modulates proliferation and differentiation of rat postnatal hippocampal neural precursor cells.
Carniglia L · Neuropharmacology · 2024
In vitro (cells) · wistar rat · 8 results
- Hormonal regulation of the mouse adrenal melanocortinergic system.
Soltani Y · Journal of endocrinological investigation · 2009
In vitro (cells) · mouse · 1 result
- A Dominant Mutation in Gαs-Protein Increases Hair Pigmentation.
Goff PS · Pigment cell & melanoma research · 2025
In vitro (cells) · mouse · 2 results
- Pharmacological function of melanocortin-3 receptor in goldfish (Carassius auratus).
Yao MX · General and comparative endocrinology · 2025
In vitro (cells) · goldfish · 3 results
- Regulation of Melanocortin-5 Receptor Pharmacology by Two Isoforms of MRAP2 in Ricefield Eel (Monopterus albus)
Liu T · Journal of the Endocrine Society · 2021
In vitro (cells) · monopterus albus · 2 results
- Change in gene expression profile induced by alpha-melanocyte stimulating hormone in a malignant mesothelioma cell line.
Colombo G · Cellular and molecular biology (Noisy-le-Grand, France) · 2006
In vitro (cells) · 5 results
- Co-operative regulation of ligand binding to melanocortin receptor subtypes: evidence for interacting binding sites.
Kopanchuk S · European journal of pharmacology · 2005
In vitro (cell-free) · 2 results
- Peptide-lipid interaction monitored by spin labeled biologically active melanocortin peptides.
Fernandez RM · Peptides · 2005
In vitro (cell-free) · 4 results
- Computational Screening of Approved Drugs for Inhibition of the Antibiotic Resistance Gene mecA in Methicillin-Resistant Staphylococcus aureus (MRSA) Strains.
Otarigho B · Biotech (Basel (Switzerland)) · 2023
In silico · 1 result
- An improved imaging agent for malignant melanoma, based on [Nle4,D-Phe7]alpha-melanocyte stimulating hormone.
Bard DR · Nuclear medicine communications · 1995
Not a test of Melanotan I (afamelanotide) alone · 8 results
- Molecular mechanism of the intracellular segments of the melanocortin-4 receptor for NDP-MSH signaling.
Yang Y · Biochemistry · 2005
Not a test of Melanotan I (afamelanotide) alone · 7 results
- Cysteine residues are involved in structure and function of melanocortin 1 receptor: Substitution of a cysteine residue in transmembrane segment two converts an agonist to antagonist.
Frändberg PA · Biochemical and biophysical research communications · 2001
Not a test of Melanotan I (afamelanotide) alone · 6 results
- Intercepting the complement amplification loop through podocyte MC5R signaling ameliorates membranous nephropathy.
Liu J · Molecular therapy : the journal of the American Society of Gene Therapy · 2025
Not a test of Melanotan I (afamelanotide) alone · 8 results
- Preclinical evaluation of MC1R targeted radiopharmaceuticals using the 203/212Pb theranostic pair.
Scaffidi-Muta JM · European journal of medicinal chemistry · 2026
Not a test of Melanotan I (afamelanotide) alone · 6 results
- A novel DOTA-alpha-melanocyte-stimulating hormone analog for metastatic melanoma diagnosis.
Froidevaux S · Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2002
Not a test of Melanotan I (afamelanotide) alone · 5 results
- A (99m)Tc(CO)(3)-labeled pyrazolyl-alpha-melanocyte-stimulating hormone analog conjugate for melanoma targeting.
Raposinho PD · Nuclear medicine and biology · 2008
Not a test of Melanotan I (afamelanotide) alone · 5 results
- Downregulation of melanocortin receptors in brain areas involved in food intake and reward mechanisms in obese (OLETF) rats.
Lindblom J · Brain research · 2000
Not a test of Melanotan I (afamelanotide) alone · 5 results
- Targeted photothermal ablation of murine melanomas with melanocyte-stimulating hormone analog-conjugated hollow gold nanospheres.
Lu W · Clinical cancer research : an official journal of the American Association for Cancer Research · 2009
Not a test of Melanotan I (afamelanotide) alone · 4 results
- Altered energy balance causes selective changes in melanocortin-4(MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: further evidence that activation of MC4-R is a physiological inhibitor of feeding.
Harrold JA · Diabetes · 1999
Not a test of Melanotan I (afamelanotide) alone · 4 results
- Lanthanide-based time-resolved fluorescence of in cyto ligand-receptor interactions.
Handl HL · Analytical biochemistry · 2004
Not a test of Melanotan I (afamelanotide) alone · 4 results
- Synthesis and evaluation of bivalent NDP-alpha-MSH(7) peptide ligands for binding to the human melanocortin receptor 4 (hMC4R).
Handl HL · Bioconjugate chemistry · 2007
Not a test of Melanotan I (afamelanotide) alone · 4 results
- In vivo evaluation of 99mTc/188Re-labeled linear alpha-melanocyte stimulating hormone analogs for specific melanoma targeting.
Chen J · Nuclear medicine and biology · 1999
Not a test of Melanotan I (afamelanotide) alone · 4 results
- Interactions of the melanocortin-4 receptor with the peptide agonist NDP-MSH.
Chapman KL · Journal of molecular biology · 2010
Not a test of Melanotan I (afamelanotide) alone · 4 results
- Substituted NDP-MSH peptides paired with mutant melanocortin-4 receptors demonstrate the role of transmembrane 6 in receptor activation.
Fleck BA · Biochemistry · 2007
Not a test of Melanotan I (afamelanotide) alone · 4 results
- Structural insight into the MC4R conformational changes via different agonist-mediated receptor signaling.
Yang Y · Biochemistry · 2014
Not a test of Melanotan I (afamelanotide) alone · 4 results
- Adjunctive use of Polypodium leucotomos extract in patients with erythropoietic protoporphyria: An exploratory study.
Shetty N · Photochemistry and photobiology · 2026
Not a test of Melanotan I (afamelanotide) alone · 4 results
- Molecular determinants of ligand binding to the human melanocortin-4 receptor.
Yang YK · Biochemistry · 2000
Not a test of Melanotan I (afamelanotide) alone · 3 results
- Controlled-release delivery system for the alpha-MSH analog melanotan-I using poloxamer 407.
Bhardwaj R · Journal of pharmaceutical sciences · 1996
Not a test of Melanotan I (afamelanotide) alone · 3 results
- Expression of melanocortin-5 receptor in secretory epithelia supports a functional role in exocrine and endocrine glands.
van der Kraan M · Endocrinology · 1998
Not a test of Melanotan I (afamelanotide) alone · 3 results
- Characterization of melanocortin NDP-MSH agonist peptide fragments at the mouse central and peripheral melanocortin receptors.
Haskell-Luevano C · Journal of medicinal chemistry · 2001
Not a test of Melanotan I (afamelanotide) alone · 3 results
- The efficacy of afamelanotide and narrowband UV-B phototherapy for repigmentation of vitiligo.
Grimes PE · JAMA dermatology · 2013
Not a test of Melanotan I (afamelanotide) alone · 3 results
- Truncation studies of alpha-melanotropin peptides identify tripeptide analogues exhibiting prolonged agonist bioactivity.
Haskell-Luevano C · Peptides · 1996
Not a test of Melanotan I (afamelanotide) alone · 3 results
- Molecular characterization of human melanocortin-3 receptor ligand-receptor interaction.
Chen M · Biochemistry · 2006
Not a test of Melanotan I (afamelanotide) alone · 3 results
- Fluorescence anisotropy assay for pharmacological characterization of ligand binding dynamics to melanocortin 4 receptors.
Veiksina S · Analytical biochemistry · 2010
Not a test of Melanotan I (afamelanotide) alone · 3 results
- Squalene-derived flexible linkers for bioactive peptides.
Jagadish B · Bioorganic & medicinal chemistry letters · 2007
Not a test of Melanotan I (afamelanotide) alone · 3 results
- Fluorescence study of conformational properties of melanotropins labeled with aminobenzoic acid.
Ito AS · Biophysical journal · 2001
Not a test of Melanotan I (afamelanotide) alone · 3 results
- Acid-base titration of melanocortin peptides: evidence of Trp rotational conformers interconversion.
Fernandez RM · Biopolymers · 2005
Not a test of Melanotan I (afamelanotide) alone · 3 results
- Silica-Assisted Solid-Phase Peptide Synthesis (SiPPS).
Nkwanyana N · Journal of peptide science : an official publication of the European Peptide Society · 2025
Not a test of Melanotan I (afamelanotide) alone · 6 results
- [Detection of binding activity and biologic effect of a novel alpha-melanocyte-stimulating hormone analogue].
Ying Y · Yao xue xue bao = Acta pharmaceutica Sinica · 2007
Not a test of Melanotan I (afamelanotide) alone · 3 results
- Polysorbate 80 coated chitosan nanoparticles for delivery of α-melanocyte stimulating hormone analog (NDP-MSH) to the brain reverse cognitive impairment related to neuroinflammation produced by a high-fat diet (HFD).
Herrera G · Neuropharmacology · 2024
Not a test of Melanotan I (afamelanotide) alone · 3 results
- Investigation of the stability profile of therapeutic α-MSH analogue: Insights from liquid chromatography-high resolution mass spectrometry analysis of afamelanotide.
Chawathe A · Journal of pharmaceutical and biomedical analysis · 2026
Not a test of Melanotan I (afamelanotide) alone · 3 results
- Interactions of human melanocortin 4 receptor with nonpeptide and peptide agonists.
Pogozheva ID · Biochemistry · 2005
Not a test of Melanotan I (afamelanotide) alone · 2 results
- Structural insights into ligand recognition and activation of the melanocortin-4 receptor.
Zhang H · Cell research · 2021
Not a test of Melanotan I (afamelanotide) alone · 3 results
- Expression of melanocortin receptors and pro-opiomelanocortin in the rat spinal cord in relation to neurotrophic effects of melanocortins.
van der Kraan M · Brain research. Molecular brain research · 1999
Not a test of Melanotan I (afamelanotide) alone · 2 results
- A tumor-targeted immune checkpoint blocker.
Zhang Y · Proceedings of the National Academy of Sciences of the United States of America · 2019
Not a test of Melanotan I (afamelanotide) alone · 2 results
- Rigid linkers for bioactive peptides.
Vagner J · Bioconjugate chemistry · 2006
Not a test of Melanotan I (afamelanotide) alone · 2 results
- Identification of ligand binding residues in extracellular loops of the melanocortin 1 receptor.
Chhajlani V · Biochemical and biophysical research communications · 1996
Not a test of Melanotan I (afamelanotide) alone · 2 results
- A novel non-synonymous mutation in the melanocortin-4 receptor gene (MC4R) in a 2-year-old Austrian girl with extreme obesity.
Rettenbacher E · Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2007
Not a test of Melanotan I (afamelanotide) alone · 2 results
- Design, synthesis, and validation of a branched flexible linker for bioactive peptides.
Bowen ME · The Journal of organic chemistry · 2007
Not a test of Melanotan I (afamelanotide) alone · 2 results