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Study · Not a test of the peptide alone · 2001

3 results

Characterization of melanocortin NDP-MSH agonist peptide fragments at the mouse central and peripheral melanocortin receptors.

Haskell-Luevano C, Holder JR, Monck EK, Bauzo RM

Journal of medicinal chemistry1 Jun 2001Cited by 67 (Europe PMC)

PMID11405661 (opens in a new tab)DOI10.1021/jm010061n (opens in a new tab)PepBankPUB-11405661
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan I (afamelanotide).

  1. 01LabNot a test of Melanotan I (afamelanotide) aloneIn vitro (cells)Activity measurement

    In cells with mouse melanocortin receptors, the NDP-MSH fragment Ac-His-DPhe-Arg-Trp-NH2 had 10 nM agonist activity at the brain MC4R.

    In plain wordsIn cells, a four-amino-acid piece of NDP-MSH activated the MC4R receptor at a low concentration.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableMC4R agonist activity of Ac-His-DPhe-Arg-Trp-NH2
    Study

    mousen: not reported in source

    mouse melanocortin MC1, MC3, MC4 and MC5 receptors
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Measurements

    agonist activity
    10 nM
    MC4R

    Source sentences

    Summary
    This study has identified the Ac-His-DPhe-Arg-Trp-NH(2) tetrapeptide as possessing 10 nM agonist activity at the brain MC4R.
    1 context sentence
    Summary · context
    These peptide analogues were pharmacologically characterized at the mouse melanocortin MC1, MC3, MC4, and MC5 receptors.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

  2. 02LabNot a test of Melanotan I (afamelanotide) aloneIn vitro (cells)Activity measurement

    In cells with mouse melanocortin receptors, the NDP-MSH fragment Ac-DPhe-Arg-Trp-NH2 had micromolar agonist activity at the MC1R, MC4R and MC5R.

    In plain wordsIn cells, a three-amino-acid piece of NDP-MSH activated the MC1R, MC4R and MC5R receptors only at high concentrations.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableAgonist activity of Ac-DPhe-Arg-Trp-NH2 at MC1R, MC4R and MC5R
    Study

    mousen: not reported in source

    mouse melanocortin MC1, MC3, MC4 and MC5 receptors
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    The tripeptide Ac-DPhe-Arg-Trp-NH(2) possessed micromolar agonist activities at the MC1R, MC4R, and MC5R
    1 context sentence
    Summary · context
    These peptide analogues were pharmacologically characterized at the mouse melanocortin MC1, MC3, MC4, and MC5 receptors.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

  3. 03LabNot a test of Melanotan I (afamelanotide) aloneIn vitro (cells)Activity measurement

    In cells with mouse melanocortin receptors, the NDP-MSH fragment Ac-DPhe-Arg-Trp-NH2 gave only slight stimulatory activity at the MC3R.

    In plain wordsIn cells, a three-amino-acid piece of NDP-MSH barely activated the MC3R receptor.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableActivity of Ac-DPhe-Arg-Trp-NH2 at MC3R
    Study

    mousen: not reported in source

    mouse melanocortin MC1, MC3, MC4 and MC5 receptors
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    The tripeptide Ac-DPhe-Arg-Trp-NH(2) possessed micromolar agonist activities at the MC1R, MC4R, and MC5R but only slight stimulatory activity was observed at the MC3R (at up to 100 microM concentration).
    1 context sentence
    Summary · context
    These peptide analogues were pharmacologically characterized at the mouse melanocortin MC1, MC3, MC4, and MC5 receptors.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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