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Study · Not a test of the peptide alone · 2007

3 results

[Detection of binding activity and biologic effect of a novel alpha-melanocyte-stimulating hormone analogue].

Ying Y, Lan XP, Tian YP

Yao xue xue bao = Acta pharmaceutica Sinica1 Mar 2007Cited by 3 (Europe PMC)

PMID17520825 (opens in a new tab)PepBankPUB-17520825
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan I (afamelanotide).

  1. 01LabNot a test of Melanotan I (afamelanotide) aloneIn vitro (cells)Activity measurement

    In HEK-293 cells expressing human melanocortin receptors, a novel alpha-MSH analogue had Ki values of 0.159 nM at MC1, 35.430 nM at MC3, 19.293 nM at MC4 and 2.230 nM at MC5.

    In plain wordsIn cells, a new alpha-MSH analogue bound the MC1 receptor most strongly and the MC3 receptor least strongly.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableKi at MC1, MC3, MC4 and MC5 receptors
    Study

    humann: not reported in source

    HEK-293 cells expressing human MC1, MC3, MC4 and MC5 receptors
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Measurements

    Ki
    0.159 nmol L(-1)
    MC1 receptor
    Ki
    35.43 nmol L(-1)
    MC3 receptor
    Ki
    19.293 nmol L(-1)
    MC4 receptor
    Ki
    2.23 nmol L(-1)
    MC5 receptor

    Source sentences

    Summary
    It is showed that K(i) values of the novel alpha-MSH analogue for MC1, MC3, MC4, and MC5 receptors were (0.159 +/- 0.040), (35.430 +/- 6.743), (19.293 +/- 2.780) and (2.230 +/- 0.670) nmol L(-1), respectively.
    1 context sentence
    Summary · context
    Binding activity and biologic effect of a novel alpha-melanocyte-stimulating hormone analogue were tested on cells transiently expressing the human melanocortin-1 (MC1), MC3, MC4, and MC5 receptors.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

  2. 02LabNot a test of Melanotan I (afamelanotide) aloneIn vitro (cells)Activity measurement

    In HEK-293 cells expressing human melanocortin receptors, a novel alpha-MSH analogue had EC50 values of 0.45 nM at MC1, 7.80 nM at MC3, 2.55 nM at MC4 and 0.33 nM at MC5.

    In plain wordsIn cells, a new alpha-MSH analogue switched on the MC5 and MC1 receptors at the lowest concentrations.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableEC50 for cAMP at MC1, MC3, MC4 and MC5 receptors
    Study

    humann: not reported in source

    HEK-293 cells expressing human MC1, MC3, MC4 and MC5 receptors
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Measurements

    EC50
    0.45 nmol L(-1)
    MC1 receptor
    EC50
    7.8 nmol L(-1)
    MC3 receptor
    EC50
    2.55 nmol L(-1)
    MC4 receptor
    EC50
    0.33 nmol L(-1)
    MC5 receptor

    Source sentences

    Summary
    Its EC50 values for MC1, MC3, MC4, and MC5 receptors were (0.45 +/- 0.07), (7.80 +/- 0.65), (2.55 +/- 0.23) and (0.33 +/- 0.09) nmol L(-1), respectively.
    1 context sentence
    Summary · context
    Binding activity and biologic effect of a novel alpha-melanocyte-stimulating hormone analogue were tested on cells transiently expressing the human melanocortin-1 (MC1), MC3, MC4, and MC5 receptors.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

  3. 03LabNot a test of Melanotan I (afamelanotide) aloneIn vitro (cells)Activity measurement

    In HEK-293 cells, the novel alpha-MSH analogue was a selective agonist of the MC1 and MC5 receptors.

    In plain wordsIn cells, the new alpha-MSH analogue acted mainly on the MC1 and MC5 receptors.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableReceptor selectivity
    Study

    humann: not reported in source

    HEK-293 cells expressing human MC1, MC3, MC4 and MC5 receptors
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    In these tests, the novel alpha-MSH analogue is a MC1R and MC5R selective agonist.
    1 context sentence
    Summary · context
    Binding activity and biologic effect of a novel alpha-melanocyte-stimulating hormone analogue were tested on cells transiently expressing the human melanocortin-1 (MC1), MC3, MC4, and MC5 receptors.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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