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Study · In vitro (cells) · goldfish · 2025

3 results

Pharmacological function of melanocortin-3 receptor in goldfish (Carassius auratus).

Yao MX, Du YY, Mo HL, Gul Y, Song QC, Yu HX, Liu KX, Wang LX, Li Y

General and comparative endocrinology9 Jan 2025

PMID39793740 (opens in a new tab)DOI10.1016/j.ygcen.2025.114662 (opens in a new tab)PepBankPUB-39793740
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In luciferase assays of goldfish MC3R, NDP-MSH effectively activated the cAMP signaling pathway.

    In plain wordsIn lab tests with goldfish receptor cells, NDP-MSH switched on the cAMP signal.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreasecAMP signaling activation via goldfish MC3R
    Study

    goldfishn: not reported in source

    goldfish MC3R luciferase reporter assay
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Luciferase assays demonstrated that various agonists, particularly NDP-MSH and ACTH (1-24), effectively activated the cAMP
  2. 02LabIn vitro (cells)Activity measurement

    In luciferase assays of goldfish MC3R, NDP-MSH effectively activated the MAPK/ERK signaling pathway.

    In plain wordsIn lab tests with goldfish receptor cells, NDP-MSH switched on the MAPK/ERK signal.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseMAPK/ERK signaling activation via goldfish MC3R
    Study

    goldfishn: not reported in source

    goldfish MC3R luciferase reporter assay
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Luciferase assays demonstrated that various agonists, particularly NDP-MSH and ACTH (1-24), effectively activated the cAMP and MAPK/ERK signaling pathways.
  3. 03LabIn vitro (cells)Mechanism

    In goldfish MC3R assays, NDP-MSH significantly inhibited NF-κB signaling, correlating with its activation of cAMP.

    In plain wordsIn lab tests with goldfish receptor cells, NDP-MSH reduced NF-κB signaling, an inflammation pathway.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseNF-κB signaling inhibition via goldfish MC3R
    Study

    goldfishn: not reported in source

    goldfish MC3R luciferase reporter assay
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, all agonists tested (α-MSH, β-MSH, ACTH (1-24), and NDP-MSH) significantly inhibited NF-κB signaling, correlating with their activation of cAMP.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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