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Study · Not a test of the peptide alone · 2009

4 results

Targeted photothermal ablation of murine melanomas with melanocyte-stimulating hormone analog-conjugated hollow gold nanospheres.

Lu W, Xiong C, Zhang G, Huang Q, Zhang R, Zhang JZ, Li C

Clinical cancer research : an official journal of the American Association for Cancer Research1 Feb 2009Cited by 189 (Europe PMC)

PMID19188158 (opens in a new tab)PMCIDPMC2727065 (opens in a new tab)DOI10.1158/1078-0432.ccr-08-1480 (opens in a new tab)PepBankPUB-19188158
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan I (afamelanotide).

  1. 01AnimalNot a test of Melanotan I (afamelanotide) aloneAnimal study (in vivo)Other

    In tumor-bearing mice, NDP-MSH-conjugated nanoparticles showed enhanced extravasation from tumor vessels and dispersion into tumor matrix compared with nonspecific PEGylated HAuNS.

    In plain wordsIn mice with tumors, nanoparticles carrying NDP-MSH spread into tumor tissue more than nanoparticles without it.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseExtravasation and dispersion in tumor matrix
    Study

    mousen: not reported in source

    Tumor-bearing nude mice
    Comparator
    Nonspecific PEGylated HAuNS
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    This resulted in enhanced extravasation of NDP-MSH-PEG-HAuNS from tumor blood vessels and their dispersion into tumor matrix compared with nonspecific PEGylated HAuNS.
    1 context sentence
    Summary · context
    The biodistribution of NDP-MSH-PEG-HAuNS was assessed at 4 hours post i.v. injection in tumor-bearing nude mice.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

  2. 02AnimalNot a test of Melanotan I (afamelanotide) aloneAnimal study (in vivo)Other

    In mice with B16/F10 melanoma, targeted NDP-MSH nanoparticles with near-IR laser irradiation at 30 J/cm2 caused selective photothermal ablation confirmed by histology and FDG-PET.

    In plain wordsIn mice, nanoparticles carrying NDP-MSH plus laser light destroyed melanoma tumour tissue, shown by tissue analysis and PET scans.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseSelective photothermal ablation of melanoma
    Study

    mousen: not reported in source

    B16/F10 melanoma in nude mice
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Successful selective photothermal ablation of B16/F10 melanoma with targeted HAuNS was confirmed by histologic and [18F]fluorodeoxyglucose positron emission tomography evaluation at 24 hours post near IR-region laser irradiation at a low-dose energy of 30 J/cm2.
    1 context sentence
    Summary · context
    Photothermal ablation effect of the nanoparticles was evaluated both histologically using excised tissue and functionally by [18F]fluorodeoxyglucose positron emission tomography.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

  3. 03LabNot a test of Melanotan I (afamelanotide) aloneIn vitro (cells)Other

    In murine B16/F10 melanoma cells, the NDP-MSH-conjugated nanoparticles were specifically taken up and recruited beta-arrestins, which indicates receptor-mediated endocytosis.

    In plain wordsIn mouse melanoma cells, the gold nanoparticles carrying NDP-MSH were taken up by the cells through receptor-mediated uptake.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseCellular uptake of NDP-MSH-PEG-HAuNS
    Study

    mousen: not reported in source

    B16/F10 melanoma cells
    Outcome group
    Receptor activity and mechanism · Cancer

    Source sentences

    Summary
    The nanoparticles were specifically taken up by melanoma cells, which initiated the recruitment of beta-arrestins, the adapters to link the activated G-protein-coupled receptors to clathrin, indicating the involvement of receptor-mediated endocytosis.
    1 context sentence
    Summary · context
    The intracellular uptake of the NDP-MSH-conjugated PEGylated HAuNS (NDP-MSH-PEG-HAuNS) and the distribution of beta-arrestin were examined in murine B16/F10 melanoma cells.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

  4. 04LabNot a test of Melanotan I (afamelanotide) aloneIn vitro (cell-free)Other

    The NDP-MSH-PEG-HAuNS conjugate had an outer diameter of 43.5 +/- 2.3 nm, a 3-4 nm gold shell and an absorption peak at 808 nm.

    In plain wordsThe gold nanoparticles carrying NDP-MSH were about 43.5 nanometres wide and absorbed near-infrared light at 808 nanometres.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableNanoparticle size and near-IR absorption
    Study

    n: not reported in source

    NDP-MSH-PEG-HAuNS nanoparticles
    Outcome group
    Receptor activity and mechanism · Cancer

    Measurements

    outer diameter
    43.5 nm
    NDP-MSH-PEG-HAuNS
    shell thickness
    3 to 4 nm
    NDP-MSH-PEG-HAuNS
    absorption peak
    808 nm
    NDP-MSH-PEG-HAuNS

    Source sentences

    Summary
    NDP-MSH-PEG-HAuNS consist only of a thin gold wall with hollow interior (outer diameter, 43.5 +/- 2.3 nm; shell thickness, 3-4 nm), which displays strong and tunable resonance absorption in near-IR region (peak, 808 nm).

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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