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Study · Not a test of the peptide alone · 2007

2 results

Design, synthesis, and validation of a branched flexible linker for bioactive peptides.

Bowen ME, Monguchi Y, Sankaranarayanan R, Vagner J, Begay LJ, Xu L, Jagadish B, Hruby VJ, Gillies RJ, Mash EA

The Journal of organic chemistry6 Feb 2007Cited by 14 (Europe PMC)

PMID17279799 (opens in a new tab)PMCIDPMC3538035 (opens in a new tab)DOI10.1021/jo062276g (opens in a new tab)PepBankPUB-17279799
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan I (afamelanotide).

  1. 01LabNot a test of Melanotan I (afamelanotide) aloneOther designOther

    A branched flexible linker with a fluorescent dansyl moiety was synthesized and used to connect two NDP-alpha-MSH ligands or two MSH(4) ligands.

    In plain wordsIn lab chemistry, a branched linker was built and used to join two NDP-alpha-MSH molecules or two weaker MSH(4) molecules.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableSynthesis of branched linker-ligand conjugates
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    A branched flexible linker that incorporates a fluorescent dansyl moiety was synthesized and used to connect two high affinity NDP-alpha-MSH ligands or two low affinity MSH(4) ligands.
    1 context sentence
    Summary · context
    The linker was incorporated into the conjugate by solid-phase synthesis.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

  2. 02LabNot a test of Melanotan I (afamelanotide) aloneOther designActivity measurement

    In vitro, the potency of binding to the human melanocortin 4 receptor was not diminished for linker-ligand combinations relative to the corresponding ligand alone.

    In plain wordsIn lab tests, joining ligands with the linker did not lower how well they bound the human MC4 receptor, compared with the single ligand.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeBinding potency at human melanocortin 4 receptor
    Study

    n: not reported in source

    Comparator
    Corresponding ligand alone
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    In vitro biological evaluations showed that potency of binding to the human melanocortin 4 receptor was not diminished for linker-ligand combinations relative to the corresponding ligand alone.
    1 context sentence
    Summary · context
    A branched flexible linker that incorporates a fluorescent dansyl moiety was synthesized and used to connect two high affinity NDP-alpha-MSH ligands or two low affinity MSH(4) ligands.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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