Skip to content

Study · In vitro (cells) · 2006

5 results

Change in gene expression profile induced by alpha-melanocyte stimulating hormone in a malignant mesothelioma cell line.

Colombo G, Sordi A, Turcatti F, Carlin A, Rossi C, Lonati C, Santambrogio L, Gatti S, Catania A

Cellular and molecular biology (Noisy-le-Grand, France)30 May 2006

PMID16914089 (opens in a new tab)PepBankPUB-16914089
Publisher pageAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In a human malignant mesothelioma cell line, NDP-alpha-MSH changed expression of genes involved in cell growth, adhesion, signal transduction and transcription.

    In plain wordsIn cancer cells, NDP-alpha-MSH changed the activity of genes linked to growth, adhesion and signaling.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    MixedGene expression profile
    Study

    humann: not reported in source

    Human malignant mesothelioma cell line
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The cDNA macroarray technique revealed changes in expression of genes involved in cell growth, adhesion, signal transduction, and transcription.
    1 context sentence
    Summary · context
    To determine the molecular mechanisms underlying such effects, we investigated the changes in gene expression profile induced by the alpha-MSH analog [Nle4 -DPhe7 ]-alpha-MSH (NDP-alpha-MSH) in a human malignant mesothelioma cell line.
  2. 02LabIn vitro (cells)Mechanism

    In a human malignant mesothelioma cell line, NDP-alpha-MSH down-regulated expression of the oncogene B-Myb.

    In plain wordsIn cancer cells, NDP-alpha-MSH lowered the activity of the B-Myb gene.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseB-Myb expression
    Study

    humann: not reported in source

    Human malignant mesothelioma cell line
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In particular, NDP-alpha-MSH down-regulated expression of B-Myb and Myc, two oncogenes considered of paramount importance for cell proliferation and cancer.
    1 context sentence
    Summary · context
    To determine the molecular mechanisms underlying such effects, we investigated the changes in gene expression profile induced by the alpha-MSH analog [Nle4 -DPhe7 ]-alpha-MSH (NDP-alpha-MSH) in a human malignant mesothelioma cell line.
  3. 03LabIn vitro (cells)Mechanism

    In a human malignant mesothelioma cell line, NDP-alpha-MSH down-regulated expression of the oncogene Myc.

    In plain wordsIn cancer cells, NDP-alpha-MSH lowered the activity of the Myc gene.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseMyc expression
    Study

    humann: not reported in source

    Human malignant mesothelioma cell line
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In particular, NDP-alpha-MSH down-regulated expression of B-Myb and Myc, two oncogenes considered of paramount importance for cell proliferation and cancer.
    1 context sentence
    Summary · context
    To determine the molecular mechanisms underlying such effects, we investigated the changes in gene expression profile induced by the alpha-MSH analog [Nle4 -DPhe7 ]-alpha-MSH (NDP-alpha-MSH) in a human malignant mesothelioma cell line.
  4. 04LabIn vitro (cells)Mechanism

    In a human malignant mesothelioma cell line, NDP-alpha-MSH exerted a favorable transcriptional regulation of certain integrins and their signaling pathways.

    In plain wordsIn cancer cells, NDP-alpha-MSH changed the activity of some integrin genes and their pathways.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    MixedIntegrin expression and signaling pathways
    Study

    humann: not reported in source

    Human malignant mesothelioma cell line
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Further, NDP-alpha-MSH exerted a favorable transcriptional regulation of certain integrins and their signaling pathways.
    1 context sentence
    Summary · context
    To determine the molecular mechanisms underlying such effects, we investigated the changes in gene expression profile induced by the alpha-MSH analog [Nle4 -DPhe7 ]-alpha-MSH (NDP-alpha-MSH) in a human malignant mesothelioma cell line.
  5. 05LabIn vitro (cells)Mechanism

    In a human malignant mesothelioma cell line, NDP-alpha-MSH treatment was associated with prominent inhibition of IL-13.

    In plain wordsIn cancer cells, NDP-alpha-MSH treatment was linked to strong lowering of IL-13, a tumor-promoting cytokine.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseIL-13 expression
    Study

    humann: not reported in source

    Human malignant mesothelioma cell line
    Outcome group
    Inflammation markers · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, peptide treatment was associated with a prominent inhibition of IL-13, a cytokine with tumor-promoting effects.
    1 context sentence
    Summary · context
    To determine the molecular mechanisms underlying such effects, we investigated the changes in gene expression profile induced by the alpha-MSH analog [Nle4 -DPhe7 ]-alpha-MSH (NDP-alpha-MSH) in a human malignant mesothelioma cell line.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.