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Study · Not a test of the peptide alone · 1998

3 results

Expression of melanocortin-5 receptor in secretory epithelia supports a functional role in exocrine and endocrine glands.

van der Kraan M, Adan RA, Entwistle ML, Gispen WH, Burbach JP, Tatro JB

Endocrinology1 May 1998Cited by 88 (Europe PMC)

PMID9564844 (opens in a new tab)DOI10.1210/endo.139.5.6008 (opens in a new tab)PepBankPUB-09564844
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan I (afamelanotide).

  1. 01AnimalNot a test of Melanotan I (afamelanotide) aloneAnimal study (in vivo)Mechanism

    In rat tissue sections, [125I]NDP-MSH binding showed melanocortin receptor protein in secretory epithelia of exocrine glands.

    In plain wordsIn rats, labeled NDP-MSH showed melanocortin receptors in the secretory cells of exocrine glands.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableMC receptor protein in secretory epithelia of exocrine glands
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    MC-R protein was likewise present in secretory epithelia of exocrine glands, as determined by 125I-labeled [Nle4,D-Phe7]alphaMSH ([125I]NDP-MSH) binding and autoradiography in tissue sections.
    1 context sentence
    Summary · context
    This study was designed to determine the identity and anatomical localization of the melanocortin receptors (MC-R) expressed in these organs in the rat.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

  2. 02AnimalNot a test of Melanotan I (afamelanotide) aloneAnimal study (in vivo)Mechanism

    In rats, specific [125I]NDP-MSH binding was observed in adrenal cortex, thymus, spleen, and esophageal and trachealis muscle.

    In plain wordsIn rats, labeled NDP-MSH bound to several other organs, including the adrenal gland, thymus and spleen.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableSpecific [125I]NDP-MSH binding in other peripheral tissues
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Specific [125I]NDP-MSH binding was also observed in adrenal cortex, thymus, spleen, and esophageal and trachealis muscle.
    1 context sentence
    Summary · context
    This study was designed to determine the identity and anatomical localization of the melanocortin receptors (MC-R) expressed in these organs in the rat.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

  3. 03AnimalNot a test of Melanotan I (afamelanotide) aloneAnimal study (in vivo)Mechanism

    In rats, specific [125I]NDP-MSH binding was observed in exocrine and adrenal glands after systemic injection in vivo.

    In plain wordsIn rats, NDP-MSH injected into the body reached receptors in exocrine glands and the adrenal gland.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableIn vivo [125I]NDP-MSH binding after systemic injection
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    MC receptors in these sites are accessible to circulating MC-R agonists in vivo, as specific binding of [125I]NDP-MSH was observed in exocrine and adrenal glands after systemic injection in vivo.
    1 context sentence
    Summary · context
    This study was designed to determine the identity and anatomical localization of the melanocortin receptors (MC-R) expressed in these organs in the rat.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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