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Study · Not a test of the peptide alone · 2024

3 results

Polysorbate 80 coated chitosan nanoparticles for delivery of α-melanocyte stimulating hormone analog (NDP-MSH) to the brain reverse cognitive impairment related to neuroinflammation produced by a high-fat diet (HFD).

Herrera G, Scimonelli T, Lasaga M, Granero G, Onnainty R

Neuropharmacology28 Apr 2024Cited by 2 (Europe PMC)

PMID38688422 (opens in a new tab)DOI10.1016/j.neuropharm.2024.109969 (opens in a new tab)PepBankPUB-38688422
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan I (afamelanotide).

  1. 01AnimalNot a test of Melanotan I (afamelanotide) aloneAnimal study (in vivo)Pharmacokinetics

    In rats, intraperitoneally injected NDP-MSH-loaded nanoparticles crossed the blood-brain barrier and accumulated in CA1 neurons of the dorsal hippocampus within 2 h.

    In plain wordsIn rats, NDP-MSH nanoparticles injected into the abdomen reached the brain and the hippocampus within 2 hours.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableBrain delivery of NDP-MSH nanoparticles
    Study

    ratn: not reported in source

    Male Wistar rats
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Intraperitoneal injection of FITC-PS80/CS NPs and [NDP-MSH]-PS80/CS NP in rats demonstrated their ability to cross the blood-brain barrier, reach the brain, and accumulate in CA1 neurons of the dorsal hippocampus within 2 h.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

  2. 02AnimalNot a test of Melanotan I (afamelanotide) aloneAnimal study (in vivo)Efficacy outcome

    In rats with 5 days of high-fat diet followed by LPS, NDP-MSH-loaded nanoparticles reversed the decreased expression of contextual fear memory.

    In plain wordsIn rats on a short high-fat diet with an immune challenge, NDP-MSH nanoparticles restored fear memory.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseContextual fear memory in the short-term high-fat diet plus LPS model
    Study

    ratn: not reported in source

    Male Wistar rats
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    In both models, [NDP-MSH]-PS80/CS NPs could reverse the decreased expression of contextual fear memory induced by the diets.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

  3. 03AnimalNot a test of Melanotan I (afamelanotide) aloneAnimal study (in vivo)Efficacy outcome

    In rats fed a high-fat diet for 8 weeks, NDP-MSH-loaded nanoparticles reversed the decreased expression of contextual fear memory.

    In plain wordsIn rats on an 8-week high-fat diet, NDP-MSH nanoparticles restored fear memory.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseContextual fear memory in the long-term high-fat diet model
    Study

    ratn: not reported in source

    Male Wistar rats
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    In both models, [NDP-MSH]-PS80/CS NPs could reverse the decreased expression of contextual fear memory induced by the diets.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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