In mouse ATC7-L adrenal cells, long-term NDP-alpha MSH treatment reduced MC4-R level by more than 30%.
In plain wordsIn mouse adrenal cells grown in the lab, long NDP-alpha MSH treatment lowered the MC4-R receptor level by more than 30%.
- Peptide
- Melanotan I (afamelanotide)
- Outcome
- DecreaseMC4-R level
- Study
mousen: not reported in source
ATC7-L mouse adrenal tumour cell line- Outcome group
- Receptor activity and mechanism · Endocrine and hormones
- Studied dose
- Dose not stated · long-term treatmentAs given in this study (mouse).
Measurements
- MC4-R reduction
- > 30%
- ATC7-L cells
Source sentences
Long-term treatment of ATC7-L with (Nle4,D-Phe7)-alpha MSH (NDP-alpha MSH) or forskolin as well as Agrp strongly reduced MC4-R level by more than 30%.
1 context sentence(design, population, supporting numbers)
In this study, we used the mouse tumoral adrenal cell line ATC7- L that secretes corticosterone in basal conditions with a 2- fold increase in response to ACTH treatment.