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Dulaglutide (Trulicity) / Studies
Conjugate · 275 amino acids

Dulaglutide (Trulicity) studies and research data

PepBank has 418 dulaglutide studies with results. 318 of them gave dulaglutide, with 1,919 results, grouped by what the studies measured. In each group, results from studies in people come first. Data as of 2026-10-30.

Searches 1,919 results and 718 papers. Newer studies from Europe PMC

Results in people
1,605
84% of 1,919 results
Results in animals
288
15% of 1,919 results
Results in lab cells
26
1% of 1,919 results
From computer models
0
0% of 1,919 results
The molecule

Dulaglutide identity

Identifiers, parent molecule, targets and development stage, from curated data.

Dulaglutide contains two identical GLP-1 analog-linker-IgG4 Fc fusion chains. Each chain contains 275 residues. The marketed glycoprotein has an approximate mass of 63 kDa. It acts at GLP-1 receptors and is distinct from other GLP-1 agonists.

Kind
Conjugate · 275 residues
Identifiers
UNIIWTT295HSY5 (opens in a new tab)DrugBankDB09045 (opens in a new tab)CAS923950-08-7
Parent
Analog of GLP-1 (7-37), humanThe official label identifies the GLP-1(7-37) analog domain. Full-chain numbering includes a linker and an Fc domain.
Development
Approved in the US and EU (Trulicity)Eli Lilly and CompanyAn approved medicinal product exists. Investigational indications and formulations have separate development status. Source (opens in a new tab)

Targets

Molecular targets with action and evidence source
TargetActionEvidence
Glucagon-like peptide-1 receptorGLP1RP43220 (opens in a new tab)Agonistofficial prescribing informationSource (opens in a new tab)

Sequence and structure

Residues, differences from the parent, calculated properties and 3D structure. Source values and calculated values are shown separately.

Sequence

275 amino acids · 2 modifications · 2 disulfide bonds

H-
Residues 1 to 10:
HGEGTFTSDV
Residues 11 to 20:
SSYLEEQAAK
Residues 21 to 30:
EFIAWLVKGG
Residues 31 to 40:
GGGGGSGGGG
Residues 41 to 50:
SGGGGSAESK
Residues 51 to 60:
YGPPCPPCPA
Residues 61 to 70:
PEAAGGPSVF
Residues 71 to 80:
LFPPKPKDTL
Residues 81 to 90:
MISRTPEVTC
Residues 91 to 100:
VVVDVSQEDP
Residues 101 to 110:
EVQFNWYVDG
Residues 111 to 120:
VEVHNAKTKP
Residues 121 to 130:
REEQFNSTYR
Residues 131 to 140:
VVSVLTVLHQ
Residues 141 to 150:
DWLNGKEYKC
Residues 151 to 160:
KVSNKGLPSS
Residues 161 to 170:
IEKTISKAKG
Residues 171 to 180:
QPREPQVYTL
Residues 181 to 190:
PPSQEEMTKN
Residues 191 to 200:
QVSLTCLVKG
Residues 201 to 210:
FYPSDIAVEW
Residues 211 to 220:
ESNGQPENNY
Residues 221 to 230:
KTTPPVLDSD
Residues 231 to 240:
GSFFLYSRLT
Residues 241 to 250:
VDKSRWQEGN
Residues 251 to 260:
VFSCSVMHEA
Residues 261 to 270:
LHNHYTQKSL
Residues 271 to 275:
SLSLG
-OH
  • HydrophobicA V I L M
  • AromaticF W Y
  • PositiveK R H
  • NegativeD E
  • PolarS T N Q
  • SpecialC G P
  • Modified residue
  • Disulfide partner

Modifications

terminus
Other modification
Homodimer with two identical 275-residue chains. Interchain disulfides join Cys55 to Cys55 and Cys58 to Cys58.
terminus
Other modification
GLP-1 analog domain, peptide linker, and modified human IgG4 Fc domain. The product is glycosylated.
Cys90–Cys150
Disulfide bond
Cys196–Cys254
Disulfide bond

Alignment to GLP-1 (7-37)

Calculated from the two sequences. Curated notes are shown as given.

29 of 31 aligned residues identical (94%) · 2 substitutions · 244 added residues · GLP-1 (7-37) 7–37

  • Top row: GLP-1 (7-37) (parent, numbered from 7)
  • Bottom row: Dulaglutide (Trulicity)
HEGTFTSDV
SSY
L
EG
Q
A
AK
E
FIAW
L
VKG
G
  • Same as parent
  • Substituted
  • Non-canonical or D-form
  • Added
  • Gap
  • Modified side chain or end

Differences from the parent

  1. 1Parent 8 · analog 2Ala → Gly · Substitution
  2. 2Not in parent · analog 14+ Leu · Added residue
  3. 3Not in parent · analog 15+ Glu · Added residue
  4. 4Not in parent · analog 16+ Glu · Added residue
  5. 5Not in parent · analog 17+ Gln · Added residue
  6. 6Not in parent · analog 18+ Ala · Added residue
  7. 7Not in parent · analog 19+ Ala · Added residue
  8. 8Not in parent · analog 20+ Lys · Added residue
  9. 9Not in parent · analog 21+ Glu · Added residue
  10. 10Not in parent · analog 22+ Phe · Added residue
  11. 11Not in parent · analog 23+ Ile · Added residue
  12. 12Not in parent · analog 24+ Ala · Added residue
  13. 13Not in parent · analog 25+ Trp · Added residue
  14. 14Not in parent · analog 27+ Val · Added residue
  15. 15Not in parent · analog 28+ Lys · Added residue
  16. 16Not in parent · analog 29+ Gly · Added residue
  17. 17Not in parent · analog 30+ Gly · Added residue
  18. 18Not in parent · analog 31+ Gly · Added residue
  19. 19Not in parent · analog 32+ Gly · Added residue
  20. 20Not in parent · analog 33+ Gly · Added residue
  21. 21Not in parent · analog 34+ Gly · Added residue
  22. 22Not in parent · analog 35+ Gly · Added residue
  23. 23Not in parent · analog 36+ Ser · Added residue
  24. 24Not in parent · analog 37+ Gly · Added residue
  25. 25Not in parent · analog 38+ Gly · Added residue
  26. 26Not in parent · analog 39+ Gly · Added residue
  27. 27Not in parent · analog 40+ Gly · Added residue
  28. 28Not in parent · analog 41+ Ser · Added residue
  29. 29Not in parent · analog 42+ Gly · Added residue
  30. 30Not in parent · analog 43+ Gly · Added residue
  31. 31Not in parent · analog 44+ Gly · Added residue
  32. 32Not in parent · analog 45+ Gly · Added residue
  33. 33Not in parent · analog 46+ Ser · Added residue
  34. 34Not in parent · analog 47+ Ala · Added residue
  35. 35Not in parent · analog 48+ Glu · Added residue
  36. 36Not in parent · analog 49+ Ser · Added residue
  37. 37Not in parent · analog 50+ Lys · Added residue
  38. 38Not in parent · analog 51+ Tyr · Added residue
  39. 39Not in parent · analog 52+ Gly · Added residue
  40. 40Not in parent · analog 53+ Pro · Added residue
  41. 41Not in parent · analog 54+ Pro · Added residue
  42. 42Not in parent · analog 55+ Cys · Added residue
  43. 43Not in parent · analog 56+ Pro · Added residue
  44. 44Not in parent · analog 57+ Pro · Added residue
  45. 45Not in parent · analog 58+ Cys · Added residue
  46. 46Not in parent · analog 59+ Pro · Added residue
  47. 47Not in parent · analog 60+ Ala · Added residue
  48. 48Not in parent · analog 61+ Pro · Added residue
  49. 49Not in parent · analog 63+ Ala · Added residue
  50. 50Not in parent · analog 64+ Ala · Added residue
  51. 51Not in parent · analog 65+ Gly · Added residue
  52. 52Not in parent · analog 67+ Pro · Added residue
  53. 53Not in parent · analog 68+ Ser · Added residue
  54. 54Not in parent · analog 69+ Val · Added residue
  55. 55Not in parent · analog 70+ Phe · Added residue
  56. 56Not in parent · analog 71+ Leu · Added residue
  57. 57Not in parent · analog 72+ Phe · Added residue
  58. 58Not in parent · analog 73+ Pro · Added residue
  59. 59Not in parent · analog 74+ Pro · Added residue
  60. 60Not in parent · analog 75+ Lys · Added residue
  61. 61Not in parent · analog 76+ Pro · Added residue
  62. 62Not in parent · analog 77+ Lys · Added residue
  63. 63Not in parent · analog 78+ Asp · Added residue
  64. 64Not in parent · analog 79+ Thr · Added residue
  65. 65Not in parent · analog 80+ Leu · Added residue
  66. 66Not in parent · analog 81+ Met · Added residue
  67. 67Not in parent · analog 82+ Ile · Added residue
  68. 68Not in parent · analog 83+ Ser · Added residue
  69. 69Not in parent · analog 84+ Arg · Added residue
  70. 70Not in parent · analog 85+ Thr · Added residue
  71. 71Not in parent · analog 86+ Pro · Added residue
  72. 72Not in parent · analog 87+ Glu · Added residue
  73. 73Not in parent · analog 88+ Val · Added residue
  74. 74Not in parent · analog 89+ Thr · Added residue
  75. 75Not in parent · analog 90+ Cys · Added residue
  76. 76Not in parent · analog 91+ Val · Added residue
  77. 77Not in parent · analog 92+ Val · Added residue
  78. 78Not in parent · analog 93+ Val · Added residue
  79. 79Not in parent · analog 94+ Asp · Added residue
  80. 80Not in parent · analog 95+ Val · Added residue
  81. 81Not in parent · analog 96+ Ser · Added residue
  82. 82Not in parent · analog 97+ Gln · Added residue
  83. 83Not in parent · analog 98+ Glu · Added residue
  84. 84Not in parent · analog 99+ Asp · Added residue
  85. 85Not in parent · analog 100+ Pro · Added residue
  86. 86Not in parent · analog 101+ Glu · Added residue
  87. 87Not in parent · analog 102+ Val · Added residue
  88. 88Not in parent · analog 104+ Phe · Added residue
  89. 89Not in parent · analog 105+ Asn · Added residue
  90. 90Not in parent · analog 106+ Trp · Added residue
  91. 91Not in parent · analog 107+ Tyr · Added residue
  92. 92Not in parent · analog 108+ Val · Added residue
  93. 93Not in parent · analog 109+ Asp · Added residue
  94. 94Not in parent · analog 110+ Gly · Added residue
  95. 95Not in parent · analog 111+ Val · Added residue
  96. 96Not in parent · analog 112+ Glu · Added residue
  97. 97Not in parent · analog 113+ Val · Added residue
  98. 98Not in parent · analog 114+ His · Added residue
  99. 99Not in parent · analog 115+ Asn · Added residue
  100. 100Not in parent · analog 117+ Lys · Added residue
  101. 101Not in parent · analog 118+ Thr · Added residue
  102. 102Not in parent · analog 119+ Lys · Added residue
  103. 103Not in parent · analog 120+ Pro · Added residue
  104. 104Not in parent · analog 121+ Arg · Added residue
  105. 105Not in parent · analog 122+ Glu · Added residue
  106. 106Not in parent · analog 123+ Glu · Added residue
  107. 107Not in parent · analog 124+ Gln · Added residue
  108. 108Not in parent · analog 125+ Phe · Added residue
  109. 109Not in parent · analog 126+ Asn · Added residue
  110. 110Not in parent · analog 127+ Ser · Added residue
  111. 111Not in parent · analog 128+ Thr · Added residue
  112. 112Not in parent · analog 129+ Tyr · Added residue
  113. 113Not in parent · analog 130+ Arg · Added residue
  114. 114Not in parent · analog 131+ Val · Added residue
  115. 115Not in parent · analog 132+ Val · Added residue
  116. 116Not in parent · analog 133+ Ser · Added residue
  117. 117Not in parent · analog 134+ Val · Added residue
  118. 118Not in parent · analog 135+ Leu · Added residue
  119. 119Not in parent · analog 136+ Thr · Added residue
  120. 120Not in parent · analog 137+ Val · Added residue
  121. 121Not in parent · analog 138+ Leu · Added residue
  122. 122Not in parent · analog 139+ His · Added residue
  123. 123Not in parent · analog 140+ Gln · Added residue
  124. 124Not in parent · analog 141+ Asp · Added residue
  125. 125Not in parent · analog 142+ Trp · Added residue
  126. 126Not in parent · analog 143+ Leu · Added residue
  127. 127Not in parent · analog 144+ Asn · Added residue
  128. 128Not in parent · analog 145+ Gly · Added residue
  129. 129Not in parent · analog 146+ Lys · Added residue
  130. 130Not in parent · analog 147+ Glu · Added residue
  131. 131Not in parent · analog 148+ Tyr · Added residue
  132. 132Not in parent · analog 149+ Lys · Added residue
  133. 133Not in parent · analog 150+ Cys · Added residue
  134. 134Not in parent · analog 151+ Lys · Added residue
  135. 135Not in parent · analog 152+ Val · Added residue
  136. 136Not in parent · analog 153+ Ser · Added residue
  137. 137Not in parent · analog 154+ Asn · Added residue
  138. 138Not in parent · analog 155+ Lys · Added residue
  139. 139Not in parent · analog 156+ Gly · Added residue
  140. 140Not in parent · analog 157+ Leu · Added residue
  141. 141Not in parent · analog 158+ Pro · Added residue
  142. 142Not in parent · analog 159+ Ser · Added residue
  143. 143Not in parent · analog 160+ Ser · Added residue
  144. 144Not in parent · analog 161+ Ile · Added residue
  145. 145Not in parent · analog 162+ Glu · Added residue
  146. 146Not in parent · analog 163+ Lys · Added residue
  147. 147Not in parent · analog 164+ Thr · Added residue
  148. 148Not in parent · analog 165+ Ile · Added residue
  149. 149Not in parent · analog 166+ Ser · Added residue
  150. 150Not in parent · analog 167+ Lys · Added residue
  151. 151Not in parent · analog 170+ Gly · Added residue
  152. 152Not in parent · analog 171+ Gln · Added residue
  153. 153Not in parent · analog 172+ Pro · Added residue
  154. 154Not in parent · analog 173+ Arg · Added residue
  155. 155Not in parent · analog 174+ Glu · Added residue
  156. 156Not in parent · analog 175+ Pro · Added residue
  157. 157Not in parent · analog 176+ Gln · Added residue
  158. 158Not in parent · analog 177+ Val · Added residue
  159. 159Not in parent · analog 178+ Tyr · Added residue
  160. 160Not in parent · analog 179+ Thr · Added residue
  161. 161Not in parent · analog 180+ Leu · Added residue
  162. 162Not in parent · analog 181+ Pro · Added residue
  163. 163Not in parent · analog 182+ Pro · Added residue
  164. 164Not in parent · analog 183+ Ser · Added residue
  165. 165Not in parent · analog 184+ Gln · Added residue
  166. 166Not in parent · analog 185+ Glu · Added residue
  167. 167Not in parent · analog 187+ Met · Added residue
  168. 168Not in parent · analog 188+ Thr · Added residue
  169. 169Not in parent · analog 189+ Lys · Added residue
  170. 170Not in parent · analog 190+ Asn · Added residue
  171. 171Not in parent · analog 191+ Gln · Added residue
  172. 172Not in parent · analog 192+ Val · Added residue
  173. 173Not in parent · analog 193+ Ser · Added residue
  174. 174Not in parent · analog 194+ Leu · Added residue
  175. 175Not in parent · analog 195+ Thr · Added residue
  176. 176Not in parent · analog 196+ Cys · Added residue
  177. 177Not in parent · analog 197+ Leu · Added residue
  178. 178Not in parent · analog 198+ Val · Added residue
  179. 179Not in parent · analog 199+ Lys · Added residue
  180. 180Not in parent · analog 200+ Gly · Added residue
  181. 181Not in parent · analog 202+ Tyr · Added residue
  182. 182Not in parent · analog 203+ Pro · Added residue
  183. 183Not in parent · analog 204+ Ser · Added residue
  184. 184Not in parent · analog 205+ Asp · Added residue
  185. 185Not in parent · analog 208+ Val · Added residue
  186. 186Not in parent · analog 209+ Glu · Added residue
  187. 187Not in parent · analog 211+ Glu · Added residue
  188. 188Not in parent · analog 212+ Ser · Added residue
  189. 189Not in parent · analog 213+ Asn · Added residue
  190. 190Not in parent · analog 214+ Gly · Added residue
  191. 191Not in parent · analog 215+ Gln · Added residue
  192. 192Not in parent · analog 216+ Pro · Added residue
  193. 193Not in parent · analog 217+ Glu · Added residue
  194. 194Not in parent · analog 218+ Asn · Added residue
  195. 195Not in parent · analog 219+ Asn · Added residue
  196. 196Not in parent · analog 220+ Tyr · Added residue
  197. 197Not in parent · analog 221+ Lys · Added residue
  198. 198Not in parent · analog 222+ Thr · Added residue
  199. 199Not in parent · analog 223+ Thr · Added residue
  200. 200Not in parent · analog 224+ Pro · Added residue
  201. 201Not in parent · analog 225+ Pro · Added residue
  202. 202Not in parent · analog 226+ Val · Added residue
  203. 203Not in parent · analog 227+ Leu · Added residue
  204. 204Not in parent · analog 228+ Asp · Added residue
  205. 205Not in parent · analog 229+ Ser · Added residue
  206. 206Not in parent · analog 230+ Asp · Added residue
  207. 207Not in parent · analog 231+ Gly · Added residue
  208. 208Not in parent · analog 232+ Ser · Added residue
  209. 209Not in parent · analog 233+ Phe · Added residue
  210. 210Not in parent · analog 234+ Phe · Added residue
  211. 211Not in parent · analog 235+ Leu · Added residue
  212. 212Not in parent · analog 236+ Tyr · Added residue
  213. 213Not in parent · analog 237+ Ser · Added residue
  214. 214Not in parent · analog 238+ Arg · Added residue
  215. 215Not in parent · analog 240+ Thr · Added residue
  216. 216Not in parent · analog 242+ Asp · Added residue
  217. 217Not in parent · analog 244+ Ser · Added residue
  218. 218Not in parent · analog 245+ Arg · Added residue
  219. 219Not in parent · analog 246+ Trp · Added residue
  220. 220Not in parent · analog 247+ Gln · Added residue
  221. 221Not in parent · analog 248+ Glu · Added residue
  222. 222Not in parent · analog 250+ Asn · Added residue
  223. 223Not in parent · analog 251+ Val · Added residue
  224. 224Not in parent · analog 252+ Phe · Added residue
  225. 225Not in parent · analog 253+ Ser · Added residue
  226. 226Not in parent · analog 254+ Cys · Added residue
  227. 227Not in parent · analog 255+ Ser · Added residue
  228. 228Not in parent · analog 256+ Val · Added residue
  229. 229Not in parent · analog 257+ Met · Added residue
  230. 230Not in parent · analog 258+ His · Added residue
  231. 231Not in parent · analog 259+ Glu · Added residue
  232. 232Not in parent · analog 260+ Ala · Added residue
  233. 233Not in parent · analog 261+ Leu · Added residue
  234. 234Not in parent · analog 262+ His · Added residue
  235. 235Not in parent · analog 263+ Asn · Added residue
  236. 236Not in parent · analog 264+ His · Added residue
  237. 237Not in parent · analog 265+ Tyr · Added residue
  238. 238Not in parent · analog 266+ Thr · Added residue
  239. 239Not in parent · analog 267+ Gln · Added residue
  240. 240Not in parent · analog 268+ Lys · Added residue
  241. 241Not in parent · analog 269+ Ser · Added residue
  242. 242Not in parent · analog 270+ Leu · Added residue
  243. 243Not in parent · analog 271+ Ser · Added residue
  244. 244Not in parent · analog 272+ Leu · Added residue
  245. 245Not in parent · analog 273+ Ser · Added residue
  246. 246Parent 36 · analog 274Arg → Leu · Substitution

Basis: The official label identifies the GLP-1(7-37) analog domain. Full-chain numbering includes a linker and an Fc domain.

Calculated from the two sequences with @pepdb/chem alignToParent (ungapped unless a gap scores higher). The record’s curated notes are shown as given.

Properties

From identity sources

No formula or molecular weight is listed for Dulaglutide (Trulicity).

Calculated from the sequence

Some values cannot be calculated. A modification changes this value and is not modeled here (for example a lipid, metal or linker).

Average mass
Not calculated
Monoisotopic mass
Not calculated
Isoelectric point (pI)
Not calculated
Net charge at pH 7.4
Not calculated
GRAVY (hydropathy)
−0.535
Mean Kyte-Doolittle hydropathy · Kyte and Doolittle 1982
Negative: hydrophilic on average.
Extinction coefficient, 280 nm (Cys reduced)
42,400 M⁻¹ cm⁻¹
5500 x Trp + 1490 x Tyr · Pace et al. 1995 (ExPASy ProtParam)
Extinction coefficient, 280 nm (all Cys as cystines)
42,775 M⁻¹ cm⁻¹
5500 x Trp + 1490 x Tyr + 125 x cystine · Pace et al. 1995 (ExPASy ProtParam)
Instability index
49.67
Dipeptide instability weights (DIWV) · Guruprasad et al. 1990
Above 40: classed as possibly unstable (ExPASy).
Aliphatic index
63.0
Mole % A + 2.9 V + 3.9 (I + L) · Ikai 1980
Boman index
1.54 kcal/mol
Mean solubility value (negated) · Boman 2003
2.48 or below: lower protein-binding potential (Boman).
Hydrophobic moment (μH)
0.553
Eisenberg scale, 100° per residue, best 11-residue window · Eisenberg et al. 1982, 1984
  • Not included: other modification. Mass, charge and pI are not calculated; use the identity-source values.
  • Defined and validated for proteins; use with care for short peptides.
  • Assumes an ideal alpha helix. Many short peptides are not helical.

@pepdb/chem 0.2.0 · EMBOSS pKa set · ExPASy residue masses

Net charge by pH

No charge curve

A modification changes this value and is not modeled here (for example a lipid, metal or linker).

Composition

  • Hydrophobic23% (62)
  • Aromatic9% (25)
  • Positive11% (31)
  • Negative12% (32)
  • Polar25% (68)
  • Special21% (57)

275 residues. Each residue counts in one class; F and W count as aromatic.

A Ala11 · 4%
I Ile5 · 2%
L Leu18 · 7%
M Met3 · 1%
V Val25 · 9%
F Phe10 · 4%
W Trp5 · 2%
Y Tyr10 · 4%
H His6 · 2%
K Lys19 · 7%
R Arg6 · 2%
D Asp10 · 4%
E Glu22 · 8%
N Asn11 · 4%
Q Gln12 · 4%
S Ser29 · 11%
T Thr16 · 6%
C Cys6 · 2%
G Gly29 · 11%
P Pro22 · 8%

3D structure

PredictedAlphaFold DB · P01275

Loads the 3D viewer (3Dmol.js, about 150 KB) and the model file from AlphaFold DB (EMBL-EBI).

  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

Predicted model of the whole UniProt entry P01275, not an experimental structure of Dulaglutide (Trulicity).

AlphaFold DB, EMBL-EBI and Google DeepMind · CC BY 4.0

Helical wheel

An ideal alpha-helix projection. It shows where the hydrophobic residues fall if the peptide folds as a helix. It does not show that it does.

Helical wheel of Dulaglutide (Trulicity), 54 residues at 100 degrees per residue. Hydrophobic moment 0.06 pointing at 329 degrees.His 1, Eisenberg consensus (normalized) -0.40H1Gly 2, Eisenberg consensus (normalized) 0.48G2Glu 3, Eisenberg consensus (normalized) -0.74E−3Gly 4, Eisenberg consensus (normalized) 0.48G4Thr 5, Eisenberg consensus (normalized) -0.05T5Phe 6, Eisenberg consensus (normalized) 1.19F6Thr 7, Eisenberg consensus (normalized) -0.05T7Ser 8, Eisenberg consensus (normalized) -0.18S8Asp 9, Eisenberg consensus (normalized) -0.90D−9Val 10, Eisenberg consensus (normalized) 1.08V10Ser 11, Eisenberg consensus (normalized) -0.18S11Ser 12, Eisenberg consensus (normalized) -0.18S12Tyr 13, Eisenberg consensus (normalized) 0.26Y13Leu 14, Eisenberg consensus (normalized) 1.06L14Glu 15, Eisenberg consensus (normalized) -0.74E−15Glu 16, Eisenberg consensus (normalized) -0.74E−16Gln 17, Eisenberg consensus (normalized) -0.85Q17Ala 18, Eisenberg consensus (normalized) 0.62A18Ala 19, Eisenberg consensus (normalized) 0.62A19Lys 20, Eisenberg consensus (normalized) -1.50K+20Glu 21, Eisenberg consensus (normalized) -0.74E−21Phe 22, Eisenberg consensus (normalized) 1.19F22Ile 23, Eisenberg consensus (normalized) 1.38I23Ala 24, Eisenberg consensus (normalized) 0.62A24Trp 25, Eisenberg consensus (normalized) 0.81W25Leu 26, Eisenberg consensus (normalized) 1.06L26Val 27, Eisenberg consensus (normalized) 1.08V27Lys 28, Eisenberg consensus (normalized) -1.50K+28Gly 29, Eisenberg consensus (normalized) 0.48G29Gly 30, Eisenberg consensus (normalized) 0.48G30Gly 31, Eisenberg consensus (normalized) 0.48G31Gly 32, Eisenberg consensus (normalized) 0.48G32Gly 33, Eisenberg consensus (normalized) 0.48G33Gly 34, Eisenberg consensus (normalized) 0.48G34Gly 35, Eisenberg consensus (normalized) 0.48G35Ser 36, Eisenberg consensus (normalized) -0.18S36Gly 37, Eisenberg consensus (normalized) 0.48G37Gly 38, Eisenberg consensus (normalized) 0.48G38Gly 39, Eisenberg consensus (normalized) 0.48G39Gly 40, Eisenberg consensus (normalized) 0.48G40Ser 41, Eisenberg consensus (normalized) -0.18S41Gly 42, Eisenberg consensus (normalized) 0.48G42Gly 43, Eisenberg consensus (normalized) 0.48G43Gly 44, Eisenberg consensus (normalized) 0.48G44Gly 45, Eisenberg consensus (normalized) 0.48G45Ser 46, Eisenberg consensus (normalized) -0.18S46Ala 47, Eisenberg consensus (normalized) 0.62A47Glu 48, Eisenberg consensus (normalized) -0.74E−48Ser 49, Eisenberg consensus (normalized) -0.18S49Lys 50, Eisenberg consensus (normalized) -1.50K+50Tyr 51, Eisenberg consensus (normalized) 0.26Y51Gly 52, Eisenberg consensus (normalized) 0.48G52Pro 53, Eisenberg consensus (normalized) 0.12P53Pro 54, Eisenberg consensus (normalized) 0.12P54
μH, residues shown
0.064
μH, best 11-residue window
0.553
Arrow direction
329°
Residues
1–54 of 275 · 3 rings of 18
HydrophilicHydrophobic

Eisenberg consensus (normalized) scale · + K, R · − D, E

Assumes an ideal α-helix: 100° per residue, 3.6 residues per turn. The arrow is the mean hydrophobic moment (Eisenberg et al. 1984) and points at the hydrophobic face.

Show as table
PositionResidueAngleEisenberg consensus (normalized)
1H0°-0.40
2G100°0.48
3E200°-0.74
4G300°0.48
5T40°-0.05
6F140°1.19
7T240°-0.05
8S340°-0.18
9D80°-0.90
10V180°1.08
11S280°-0.18
12S20°-0.18
13Y120°0.26
14L220°1.06
15E320°-0.74
16E60°-0.74
17Q160°-0.85
18A260°0.62
19A0°0.62
20K100°-1.50
21E200°-0.74
22F300°1.19
23I40°1.38
24A140°0.62
25W240°0.81
26L340°1.06
27V80°1.08
28K180°-1.50
29G280°0.48
30G20°0.48
31G120°0.48
32G220°0.48
33G320°0.48
34G60°0.48
35G160°0.48
36S260°-0.18
37G0°0.48
38G100°0.48
39G200°0.48
40G300°0.48
41S40°-0.18
42G140°0.48
43G240°0.48
44G340°0.48
45G80°0.48
46S180°-0.18
47A280°0.62
48E20°-0.74
49S120°-0.18
50K220°-1.50
51Y320°0.26
52G60°0.48
53P160°0.12
54P260°0.12
Results by area

What the studies measured

People first in each area, then animals, then lab cells. Counts are exact and come from studies that gave the peptide.

Trials and papers
Status and safety
Data

Compare