Study · Animal study (in vivo) · mouse · 2021
17 resultsKhin PP, Hong Y, Yeon M, Lee DH, Lee JH, Jun HS
Aging19 Sept 2021Cited by 32 (Europe PMC)
17 results from studies that gave the peptide. No result from this study comes from people.
In aged mice, dulaglutide improved muscle mass.
In plain wordsIn aged mice, dulaglutide improved muscle mass compared with vehicle.
mousen: not reported in source
Aging muscleSource sentences
Dulaglutide improved muscle mass and strength in aged mice.
In aged mice, dulaglutide improved muscle strength.
In plain wordsIn aged mice, dulaglutide improved muscle strength compared with vehicle.
mousen: not reported in source
Aging muscleSource sentences
Dulaglutide improved muscle mass and strength in aged mice.
In aged mice, dulaglutide increased tibialis anterior cross-sectional area versus vehicle.
In plain wordsIn aged mice, dulaglutide increased muscle cross-sectional area compared with vehicle.
mousen: not reported in source
Aging muscleSource sentences
Histological analysis revealed that the cross-sectional area of the tibialis anterior (TA) in the dulaglutide-treated group was thicker than that in the vehicle group.
In young and aged mice, dulaglutide shifted fibers toward middle and large sizes versus vehicle.
In plain wordsIn young and aged mice, dulaglutide increased the shift toward larger muscle fibers compared with vehicle.
mousen: not reported in source
Aging muscleSource sentences
Moreover, dulaglutide increased the shift toward middle and large-sized fibers in both young and aged mice compared to the vehicle.
In young mice, dulaglutide increased type I myofibers by 18.5% versus vehicle.
In plain wordsIn young mice, dulaglutide increased type I muscle fibers compared with vehicle.
mousen: not reported in source
Aging muscleSource sentences
Dulaglutide increased myofiber type I and type IIa in young (18.5% and 8.2%) and aged (1.8% and 19.7%) mice, respectively, compared to the vehicle group.
In young mice, dulaglutide increased type IIa myofibers by 8.2% versus vehicle.
In plain wordsIn young mice, dulaglutide increased type IIa muscle fibers compared with vehicle.
mousen: not reported in source
Aging muscleSource sentences
Dulaglutide increased myofiber type I and type IIa in young (18.5% and 8.2%) and aged (1.8% and 19.7%) mice, respectively, compared to the vehicle group.
In aged mice, dulaglutide increased type I myofibers by 1.8% versus vehicle.
In plain wordsIn aged mice, dulaglutide increased type I muscle fibers compared with vehicle.
mousen: not reported in source
Aging muscleSource sentences
Dulaglutide increased myofiber type I and type IIa in young (18.5% and 8.2%) and aged (1.8% and 19.7%) mice, respectively, compared to the vehicle group.
In aged mice, dulaglutide increased type IIa myofibers by 19.7% versus vehicle.
In plain wordsIn aged mice, dulaglutide increased type IIa muscle fibers compared with vehicle.
mousen: not reported in source
Aging muscleSource sentences
Dulaglutide increased myofiber type I and type IIa in young (18.5% and 8.2%) and aged (1.8% and 19.7%) mice, respectively, compared to the vehicle group.
In aged mice, dulaglutide increased PGC-1α.
In plain wordsIn aged mice, dulaglutide increased PGC-1α compared with vehicle.
mousen: not reported in source
Aging muscleSource sentences
Peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α), a master regulator of mitochondrial biogenesis, decreased but increased by dulaglutide in aged mice.
In aged mice, dulaglutide decreased myostatin expression.
In plain wordsIn aged mice, dulaglutide reduced myostatin expression compared with vehicle.
mousen: not reported in source
Aging muscleSource sentences
The expression of atrophic factors such as myostatin, atrogin-1, and muscle RING-finger protein-1 was decreased in aged mice, whereas that of the myogenic factor, MyoD, was increased in both young and aged mice following dulaglutide treatment.
In aged mice, dulaglutide decreased atrogin-1 expression.
In plain wordsIn aged mice, dulaglutide reduced atrogin-1 expression compared with vehicle.
mousen: not reported in source
Aging muscleSource sentences
The expression of atrophic factors such as myostatin, atrogin-1, and muscle RING-finger protein-1 was decreased in aged mice, whereas that of the myogenic factor, MyoD, was increased in both young and aged mice following dulaglutide treatment.
In aged mice, dulaglutide decreased muscle RING-finger protein-1 expression.
In plain wordsIn aged mice, dulaglutide reduced muscle RING-finger protein-1 expression compared with vehicle.
mousen: not reported in source
Aging muscleSource sentences
The expression of atrophic factors such as myostatin, atrogin-1, and muscle RING-finger protein-1 was decreased in aged mice, whereas that of the myogenic factor, MyoD, was increased in both young and aged mice following dulaglutide treatment.
In young and aged mice, dulaglutide increased MyoD expression.
In plain wordsIn young and aged mice, dulaglutide increased MyoD expression compared with vehicle.
mousen: not reported in source
Aging muscleSource sentences
The expression of atrophic factors such as myostatin, atrogin-1, and muscle RING-finger protein-1 was decreased in aged mice, whereas that of the myogenic factor, MyoD, was increased in both young and aged mice following dulaglutide treatment.
In aged mice, dulaglutide reversed the decrease in OPA-1 protein in muscles.
In plain wordsIn aged mice, dulaglutide reversed the decrease in muscle OPA-1 protein compared with vehicle.
mousen: not reported in source
Aging muscleSource sentences
In contrast, dulaglutide administration reversed this expression pattern, thereby significantly attenuating the expression of inflammatory cytokines in aged mice.
In aged mice, optic atrophy-1 (OPA-1) protein was decreased, whereas Toll-like receptor-9 (TLR-9) and its targeting inflammatory cytokines (interleukin-6 [IL-6] and tumor necrosis factor-α [TNF-α]) were elevated in the TA and quadriceps (QD) muscles.
In aged mice, dulaglutide reversed elevated muscle TLR-9 expression.
In plain wordsIn aged mice, dulaglutide reversed increased muscle TLR-9 expression compared with vehicle.
mousen: not reported in source
Aging muscleSource sentences
In contrast, dulaglutide administration reversed this expression pattern, thereby significantly attenuating the expression of inflammatory cytokines in aged mice.
In aged mice, optic atrophy-1 (OPA-1) protein was decreased, whereas Toll-like receptor-9 (TLR-9) and its targeting inflammatory cytokines (interleukin-6 [IL-6] and tumor necrosis factor-α [TNF-α]) were elevated in the TA and quadriceps (QD) muscles.
In aged mice, dulaglutide attenuated muscle IL-6 expression.
In plain wordsIn aged mice, dulaglutide reduced muscle IL-6 expression compared with vehicle.
mousen: not reported in source
Aging muscleSource sentences
In contrast, dulaglutide administration reversed this expression pattern, thereby significantly attenuating the expression of inflammatory cytokines in aged mice.
In aged mice, optic atrophy-1 (OPA-1) protein was decreased, whereas Toll-like receptor-9 (TLR-9) and its targeting inflammatory cytokines (interleukin-6 [IL-6] and tumor necrosis factor-α [TNF-α]) were elevated in the TA and quadriceps (QD) muscles.
In aged mice, dulaglutide attenuated muscle TNF-α expression.
In plain wordsIn aged mice, dulaglutide reduced muscle TNF-α expression compared with vehicle.
mousen: not reported in source
Aging muscleSource sentences
In contrast, dulaglutide administration reversed this expression pattern, thereby significantly attenuating the expression of inflammatory cytokines in aged mice.
In aged mice, optic atrophy-1 (OPA-1) protein was decreased, whereas Toll-like receptor-9 (TLR-9) and its targeting inflammatory cytokines (interleukin-6 [IL-6] and tumor necrosis factor-α [TNF-α]) were elevated in the TA and quadriceps (QD) muscles.
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Version 2Current
22 Oct 2026, 02:25 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC
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